DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and BRPF3

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_056510.2	Gene:	BRPF3 / 27154	HGNCID:	14256	Length:	1205	Species:	Homo sapiens

Alignment Length:	176	Identity:	43/176 - (24%)
Similarity:	72/176 - (40%)	Gaps:	42/176 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 GKRASIC-RCRSDMVKISMETFVRRFQPER-YDNWLKGQDMGC--HPEEPGKICAAAPPTLNEYE 367
            |:|.|:. :...:.||:..       .|:| .:|   |:|.|.  .|..|..|         |.|
Human   924 GRRTSVLFKKAKNGVKLQR-------SPDRVLEN---GEDHGVAGSPASPASI---------EEE 969

  Fly   368 KQENLR-----AAKSE-EESPQKRGCSLAGNGCERNAESAEDVDDKASVS---SYSSCRQLQPVV 423
            :....|     .::|| |.|||:...:...||..::.||..|.:....:|   ::.:|..|.|..
Human   970 RHSRKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGLTPPK 1034

  Fly   424 KLRKLPTIASVP--EPSSAPKRYDFNTEAVVRVKRLWNELPCPDRG 467
            :.|..|.::.||  |..:....|:.:..:::        ||..|||
Human  1035 RSRGKPALSRVPFLEGVNGDSDYNGSGRSLL--------LPFEDRG 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224
BRPF3	NP_056510.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		EPL1	48..194	CDD:287484
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..121
		PHD_BRPF	212..265	CDD:277047
		ePHD_BRPF3	269..386	CDD:277173
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..472
		Bromo_brd1_like	593..690	CDD:99944
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..897
		DUF4628	<848..972	CDD:292069	16/66 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	907..926		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..1015		25/102 (25%)
		BR140_related	1074..1189	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900