DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm4A and Kdm4a

DIOPT Version :9

Sequence 1:NP_610331.1 Gene:Kdm4A / 35744 FlyBaseID:FBgn0033233 Length:495 Species:Drosophila melanogaster
Sequence 2:NP_001155295.1 Gene:Kdm4a / 230674 MGIID:2446210 Length:1064 Species:Mus musculus


Alignment Length:516 Identity:244/516 - (47%)
Similarity:324/516 - (62%) Gaps:75/516 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 EEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIP 74
            |..|...|||||.|:.|||:|||.||.||||:|||.|||||:.||.||.||.|..|||  ::.||
Mouse     6 ETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRTSYDDID--DLVIP 68

  Fly    75 APICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLY 139
            |||.|:|||..|::.|.|| |::.||:|:|.:.|||:.:.|||:.::::||||||||:|:..|:|
Mouse    69 APIQQLVTGQSGLFTQYNI-QKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIY 132

  Fly   140 AADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSI 204
            .|||.|:|.::.:|.||||||.|||:||..:..|.|:||||.||||||||:||||||||||||||
Mouse   133 GADVNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSI 197

  Fly   205 NYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQ 269
            ||||||.||:||::||.:|:|||:||...|..:.|.|.|:||||||:|||.:|:::.||::|:||
Mouse   198 NYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQ 262

  Fly   270 EAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPE 334
            ||||.|||||:|||||||||||.|||||||::|||||||:|.:|.||.|||||||:.||||||||
Mouse   263 EAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPE 327

  Fly   335 RYDNWLKGQDM--------------------GCHPEEPGKICAAAPPTLNEYEKQENLRAAKSEE 379
            ||..|..|:|.                    |..|....:.|           .:|::.||...|
Mouse   328 RYKLWKAGKDSMVIDHTLPTPEAAEFLKDSGGLTPRAGSEEC-----------PEEDVEAADQGE 381

  Fly   380 ESPQKRGCSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRY 444
            |...||..:....|.:|                :..|.::...|...:|     .|:...:..:|
Mouse   382 EGDVKRSLAKHRIGTKR----------------HRVCLEIPQEVSQSEL-----FPKEELSSGQY 425

  Fly   445 DFN----TEAVVR-----VKRLWNELPCPDRGANLLTNGVVKNTKRMRF-QTKVLTLDDED 495
            :..    |.|.||     |:::.:.||.||          ..:...::| :.|.:.|::||
Mouse   426 EMTECPATLAPVRPTHSSVRQVEDSLPFPD----------YSDPTEVKFEELKNVKLEEED 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm4ANP_610331.1 JmjN 17..59 CDD:301729 30/41 (73%)
JmjC 182..298 CDD:202224 83/115 (72%)
Kdm4aNP_001155295.1 JmjN 13..55 CDD:128818 30/41 (73%)
JmjC 175..291 CDD:334913 83/115 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..384 8/40 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..489 13/53 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 502..537
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 549..573
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 590..643
Interaction with NCOR1. /evidence=ECO:0000250 597..638
PHD_SF 667..766 CDD:389947
ePHD_JMJD2A 775..884 CDD:277183
Tudor_2 902..936 CDD:375553
Tudor_2 960..994 CDD:375553
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 210 1.000 Domainoid score I2810
eggNOG 1 0.900 - - E1_COG5141
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2611
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000582
OrthoInspector 1 1.000 - - mtm8759
orthoMCL 1 0.900 - - OOG6_100918
Panther 1 1.100 - - O PTHR10694
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2594
SonicParanoid 1 1.000 - - X490
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.750

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