DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and KDM4B

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_005259578.2	Gene:	KDM4B / 23030	HGNCID:	29136	Length:	1130	Species:	Homo sapiens

Alignment Length:	448	Identity:	237/448 - (52%)
Similarity:	305/448 - (68%)	Gaps:	49/448 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIPAP 76
            ||...:||||||:.|||::|:.|:.||||:|||.||||||.||.||.||::..|||::  .||||
Human     9 QNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDV--VIPAP 71

  Fly    77 ICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAA 141
            |.|||||..|::.|.|| |::.||:.::...||||.:.||||.|:||||||||||:|::||:|.|
Human    72 IQQVVTGQSGLFTQYNI-QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGA 135

  Fly   142 DVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINY 206
            |:.|||.|:|:..||||.|.|||::|..:...||:||||.||||||||::|||||||||||||||
Human   136 DISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINY 200

  Fly   207 LHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEA 271
            ||||.||:||||||.:|:|||:||...|..:.|.|:|:||||||:|||.:|:::.||:::|||||
Human   201 LHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEA 265

  Fly   272 GEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERY 336
            ||.|||||:|||||||||||.|||||||:.|||:|||.|:.|.||.|||||||:.|||..|||||
Human   266 GEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERY 330

  Fly   337 DNWLKGQDMGC--HPEEPGKICAAAPPTLNEYEK----------------QENLRAAKSEEESPQ 383
            :.|.:|:|:..  |.    :..|...|.|:.:..                :||....|:|||
Human   331 ELWKQGKDLTVLDHT----RPTALTSPELSSWSASRASLKAKLLRRQISLKENRHWRKTEEE--- 388

  Fly   384 KRGCSLAGNGCERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAP 441
             |..||     ||..|..:    :..:||:.  ::.||     |.|.    ||....|
Human   389 -RKPSL-----ERKKEQTK----RPGLSSHR--KRSQP-----KKPK----PEDPKFP 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	28/41 (68%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	84/115 (73%)
KDM4B	XP_005259578.2	JmjN	15..56	CDD:128818	28/40 (70%)
		JmjC	176..292	CDD:202224	84/115 (73%)
		PHD_JMJD2B	717..822	CDD:277051
		ePHD_JMJD2B	831..940	CDD:277184
		TUDOR	955..1007	CDD:197660
		TUDOR	1009..1064	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2814
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27773
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1496
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8529
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760