DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and Kdm4b

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_030105461.1	Gene:	Kdm4b / 193796	MGIID:	2442355	Length:	1124	Species:	Mus musculus

Alignment Length:	502	Identity:	246/502 - (49%)
Similarity:	321/502 - (63%)	Gaps:	67/502 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNINMTIPAP 76
            ||...:||||||:.:||::|:.|:.||||:|||.||||||.||.||.||::..|||::  .||||
Mouse     9 QNPSCKIMTFRPTMDEFRDFNRYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDV--VIPAP 71

  Fly    77 ICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYISPLYAA 141
            |.|||||..|::.|.|| |::.||:.::...||||.:.||||.|:||||||||||:|::||:|.|
Mouse    72 IQQVVTGQSGLFTQYNI-QKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGA 135

  Fly   142 DVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMDLYSINY 206
            |:.|||.|:|:..||||.|.|||::|..:...||:||||.||||||||::|||||||||||||||
Mouse   136 DISGSLYDDDVAQWNIGNLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINY 200

  Fly   207 LHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYNKITQEA 271
            ||||.||:||||||.:|:|||:||...|..:.|.|:|:||||||:|||.:|:::.||:::|||||
Mouse   201 LHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEA 265

  Fly   272 GEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRRFQPERY 336
            ||.|||||:|||||||||||.|||||||:.|||:|||.|:.|.||.|||||||:.|||..|||||
Mouse   266 GEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERY 330

  Fly   337 DNWLKGQDMGC--HPEEPGKICAAAPPTLNEYE------KQENLRA----------AKSEEE--- 380
            :.|.:|:|:..  |.    :..|.:.|.|:.:.      |.:.||.          .|:|||
Mouse   331 EQWKQGRDLTVLDHT----RPTALSSPELSSWSASRTSIKAKLLRRQISVKESRPWRKAEEERRR 391

  Fly   381 SPQKR-----------------------GCSLAG-------NGCERNAESAEDVDDKASVSSYS- 414
            .|.:|                       |.:.||       .||.|.....||.:::..:.|..
Mouse   392 EPTRRPGPASHRRRSQPKKSKPEESRSPGEATAGVSTLDEARGCSRGEAMPEDEEEEELLPSQGH 456

  Fly   415 SCRQLQPVVKLRKLPTIA----SVPEPSSAPKRYD----FNTEAVVR 453
            ....::...:.:..||.|    ..|.|||.|....    |.||.|:|
Mouse   457 EAEGVEEDGRGKPRPTKARNKKKTPSPSSPPLLSAPPALFPTEEVLR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	27/41 (66%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	84/115 (73%)
Kdm4b	XP_030105461.1	JmjN	15..56	CDD:128818	27/40 (68%)
		JmjC	176..292	CDD:334913	84/115 (73%)
		PHD_SF	680..814	CDD:389947
		PHD_SF	823..932	CDD:389947
		Tudor_2	948..982	CDD:375553
		Tudor_2	1006..1040	CDD:375553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2810
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H27773
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm8759
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710