Protein Alignment Kdm4A and jmjd-2

DIOPT Version :10

• Sequence 1: NP_610331.1
• Gene: Kdm4A / 35744
• FlyBaseID: FBgn0033233
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_496969.2
• Gene: jmjd-2 / 175080
• WormBaseID: WBGene00012982
• Length: 922
• Species: Caenorhabditis elegans
• Alignment Length: 492
• Identity: 187/492 - (38%)
• Similarity: 250/492 - (50%)
• Gaps: 67/492 - (13%)

  Fly    11 EQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHL-AGLAKIQPPAEWVP---RKSGYDIDNINM 71
            |......::||.|:..||:|||.||:.||..|.|| ||:|||..|..|.|   ||...|:|:..:
 Worm    80 EPTGTSEVLTFYPTMREFKNFSQYIKKIEQNGGHLKAGIAKIVAPEGWTPRPTRKDFSDVDDYEI 144

  Fly    72 TIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPR-HFDYDDLERKYWKNITYI 135
            |.||......|...|.|.:.|:..||:|.:|:|...|||..::.|| .....::|:.|:.||.:.
 Worm   145 TQPARETIEATEKPGAYFKRNVTCRRKMPVREFRTLANSAQYRNPRPDLKGSEIEKHYFDNILHG 209

  Fly   136 SPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMD 200
            .|:|.||.:||..|..::.||:.||.|||.    |.|..|.||||.||||||:|::|.||.||||
 Worm   210 EPIYGADTEGSFYDAQVEEWNMNRLGTILE----DTNYEIKGVNTVYLYFGMYKTTFPWHAEDMD 270

  Fly   201 LYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQ-----ECNAYLRHKMTMISPKVLRQH 260
            |||||:|||||||.|:||...:..|.|:..::.||  ||     :|.|:||||..:::|::|||.
 Worm   271 LYSINFLHFGAPKYWFAISSEHADRFERFMSQQFS--YQNEYAPQCKAFLRHKTYLVTPELLRQA 333

  Fly   261 NIPYNKITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISME 325
            .|||..:.|...|.:||||.|||.|||.|:|.||||||||:|||:|||.|.:|.|..|.|||.|.
 Worm   334 GIPYATMVQRPNEFIITFPRGYHMGFNLGYNLAESTNFASQRWIDYGKDAVLCDCNKDSVKIDMT 398

  Fly   326 TFVRRFQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQENLRAAKSEEESPQKRGCSLA 390
            .|:.:::|:.|..|                      ....|.....|...|.::|.|:||..|||
 Worm   399 HFMAKYRPDEYTTW----------------------WTYWYGGGRELWIPKKKKEVPKKRRQSLA 441

  Fly   391 GNG----CERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFNTEAV 451
            ...    ..|...|:...|...|..|..|....:....:|.||...:|..
 Worm   442 DASKIAKRARLGASSTATDSDGSSGSSGSEEATEGSSFMRALPAGYTVHN--------------- 491

  Fly   452 VRVKRLWNELPCPDRGANLLTNGVVKNTKRMRFQTKV 488
                  |...|..|.    |.....|.||.:|..|::
 Worm   492 ------WQLRPDYDE----LLRKYKKETKLLRSDTRI 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:472837	22/42 (52%)
		JmjC	182..298	CDD:396791	66/120 (55%)
jmjd-2	NP_496969.2	JmjN	86..129	CDD:128818	22/42 (52%)
		JmjC	252..371	CDD:396791	66/120 (55%)
		PHD_SF	536..603	CDD:473978
		PHD_SF	588..629	CDD:473978
		ePHD	642..782	CDD:277046
		Tudor_SF	864..908	CDD:470623