DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kdm4A and kdm4aa

DIOPT Version :9

Sequence 1:	NP_610331.1	Gene:	Kdm4A / 35744	FlyBaseID:	FBgn0033233	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_001921829.2	Gene:	kdm4aa / 100003413	ZFINID:	ZDB-GENE-110609-4	Length:	2012	Species:	Danio rerio

Alignment Length:	492	Identity:	236/492 - (47%)
Similarity:	324/492 - (65%)	Gaps:	38/492 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SFADEEQNKVPRIMTFRPSYEEFQNFSAYIEYIESRGAHLAGLAKIQPPAEWVPRKSGYDIDNIN 70
            |.:...|:...|||||.|:.|||::|:.||.|:||:|||.||:||:.||.:|.||::..||:  :
Zfish     5 SVSQSSQSPATRIMTFHPTKEEFKDFNRYIAYMESQGAHRAGMAKVVPPKDWKPRRTYDDIE--D 67

  Fly    71 MTIPAPICQVVTGAHGVYQQINIQQRRQMTLRQFMEKANSELHQTPRHFDYDDLERKYWKNITYI 135
            :.||.||.|||||..|::.|.|| |::.||:|:|.:.||::....||:.|:::||||:|||:|:.
Zfish    68 LVIPTPIQQVVTGQSGLFTQYNI-QKKPMTVREFRKTANTDKFSNPRYADFEELERKFWKNLTFN 131

  Fly   136 SPLYAADVKGSLSDEDLDVWNIGRLDTILNLVNTDYNIIIDGVNTAYLYFGMWKSSFAWHTEDMD 200
            .|||.|||.|:|.|.|:..||||||:|||::|..:..|.|.||||.|||||||||:|||||||||
Zfish   132 PPLYGADVSGTLYDPDVMEWNIGRLNTILDMVERESGITIKGVNTPYLYFGMWKSTFAWHTEDMD 196

  Fly   201 LYSINYLHFGAPKTWYAIPPAYGRRLEKLANETFSENYQECNAYLRHKMTMISPKVLRQHNIPYN 265
            ||||||||||.||:||.:||.:|:|||:||...|..:.|.|.|:||||||:|||.:||::.||:.
Zfish   197 LYSINYLHFGEPKSWYVVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPSILRKYGIPFE 261

  Fly   266 KITQEAGEIMITFPFGYHAGFNHGFNGAESTNFASKRWIEYGKRASICRCRSDMVKISMETFVRR 330
            |:|||||:.::|||:|||||||||||.|||||||::|||:|||.|::|.||.|||||||:.||.:
Zfish   262 KVTQEAGQFIVTFPYGYHAGFNHGFNCAESTNFATQRWIDYGKLATLCSCRKDMVKISMDVFVHK 326

  Fly   331 FQPERYDNWLKGQDMGCHPEEPGKICAAAPPTLNEYEKQ-ENLRAAKSEE-ESPQKRGCSLAGNG 393
            ||||||..|..|:|.  .|.:..|    ..|.:.|.:|: |....:.||. |:.::||.:.||:.
Zfish   327 FQPERYKLWKAGKDN--VPIDHSK----PTPEVAEIQKENEKGEISDSERAETLEERGEAEAGDQ 385

  Fly   394 CERNAESAEDVDDKASVSSYSSCRQLQPVVKLRKLPTIASVPEPSSAPKRYDFNTEAVVRVKRLW 458
            .:.|.:..|  :|||...|       :.|||          .|..:..::.:...|..||
Zfish   386 QKANTDDGE--EDKAEAFS-------EKVVK----------RESDAGKEKAEAEVEKSVR----- 426

  Fly   459 NELPCPDRGANLLTNGVVKNT--KRMRFQTKVLTLDD 493
            :|.| ......:.::...:||  ||:|..|.....||
Zfish   427 DEEP-SSTSEQISSSSPKQNTGQKRLRSSTDNEAKDD 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kdm4A	NP_610331.1	JmjN	17..59	CDD:301729	25/41 (61%)
Kdm4A	NP_610331.1	JmjC	182..298	CDD:202224	81/115 (70%)
kdm4aa	XP_001921829.2	JmjN	16..58	CDD:128818	25/41 (61%)
		JmjC	178..294	CDD:202224	81/115 (70%)
		PHD_SF	1618..1714	CDD:304600
		PHD_SF	1723..1832	CDD:304600
		TUDOR	1847..1902	CDD:197660
		TUDOR	1904..1959	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578734
Domainoid	1	1.000	212	1.000	Domainoid score	I2716
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		mtm6370
orthoMCL	1	0.900	-	-		OOG6_100918
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2594
SonicParanoid	1	1.000	-	-		X490
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.740