DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and Cul4a

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_666319.2	Gene:	Cul4a / 99375	MGIID:	1914487	Length:	759	Species:	Mus musculus

Alignment Length:	770	Identity:	236/770 - (30%)
Similarity:	372/770 - (48%)	Gaps:	84/770 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DIWSELVEGIMQVFEHEKSLTRSQYMRF-----YTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKK 77
            |.|.:|.|.:       |::..|..:|:     |..|.:.|                 :..|...
Mouse    61 DTWRKLHEAV-------KAIQSSTSIRYNLEELYQAVENLC-----------------SHKVSPT 101

  Fly    78 LYDRLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECE 141
            ||.:|.|..:.::...:..|:..|.:.|| |.:....|:.:.....::..|..:|:|.:|.:
Mouse   102 LYKQLRQVCEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ--- 163

  Fly   142 EGQKGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSF 204
              ...:..|:.:.|..::.|:.  :::.......:|..|..||.|:.::|||:|.::....:
Mouse   164 --NSMLPSIWDMGLELFRNHIISDRMVQSKTIDGILLLIGRERSGEAVDRSLLRSLLSMLSD--- 223

  Fly   205 NEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGF 269
                       |.|||.:||.||:.:|:..|..|....:....|.|||.||..|||||..||
Mouse   224 -----------LQVYKDSFELKFLEETNCLYAAEGQRLMQDREVPEYLNHVSKRLEEEADRV--- 274

  Fly   270 NSKNGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLT 333
                 ::||..:|...|.:..|:.|:.:|| .|.....::||:.:|..||.:||.|.:.....
Mouse   275 -----ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLEHLLDENRVPDLTQMYQLFSRVKGG-- 332

  Fly   334 DLKSILENHILHQGTEAIAKCCTTDAAN--DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALD 396
                  ::.:|...:|.|....||...|  ..|..||.:||...|.:.:|...|..:..|:..:.
Mouse   333 ------QHALLQHWSEYIKTFGTTIVINPEKDKDMVQDLLDFKDKVDHVVEVCFQRNERFINLMK 391

  Fly   397 KACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVF 461
            ::...|||..       .:|..||:||:.|..|:..:|...|:|||..|:::|::|::|..||||
Mouse   392 ESFETFINKR-------PNKPAELIAKHVDSKLRAGNKEATDEELERILDKIMILFRFIHGKDVF 449

  Fly   462 QKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAE 526
            :.:|.|.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:..:|||::..
Mouse   450 EAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQN 514

  Fly   527 KNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELI 591
            ::....||..:.:|:.|.||........||.|:.|....|..||..:||||||.|  |...|..:
Mouse   515 QSAPGPIDLTVNILTMGYWPTYTPMEVHLPPEMVRLQEVFKTFYLGKHSGRKLQW--QTTLGHAV 577

  Fly   592 MNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTS 654
            :..:...... ..|.|.||..|||.||:...|:.::::..|..:...|.:.||.|.  ||:||..
Mouse   578 LKADFKEGKK-EFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIK 641

  Fly   655 SDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKM 719
            |.....:..........|:|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||
Mouse   642 SPKGKEVEDGDKFIFNADFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKM 706

  Fly   720 RKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ||.|.|..|:||:.|||  :|..|...:||.|:.||:::|:||.:...:.|.|:|
Mouse   707 RKTLGHNLLVSELYNQL--KFPVKPGDLKKRIESLIDRDYMERDKDSPNQYHYVA 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	188/660 (28%)
		CULLIN	454..593	CDD:214545	59/138 (43%)
		Cullin_Nedd8	701..765	CDD:214883	32/63 (51%)
Cul4a	NP_666319.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Cullin	65..659	CDD:279260	188/662 (28%)
		CULLIN	442..582	CDD:214545	59/141 (42%)
		Cullin_Nedd8	688..753	CDD:214883	32/66 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830