DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and CUL3

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_011517.1	Gene:	CUL3 / 852886	SGDID:	S000003235	Length:	744	Species:	Saccharomyces cerevisiae

Alignment Length:	742	Identity:	163/742 - (21%)
Similarity:	316/742 - (42%)	Gaps:	101/742 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 GKKLYDRLEQFLKSYLSELL-TKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVK- 137
            |..||:||:.:|...|:.|. |..|..:.:...|....:.|:.......:...:..|:::.:.|
Yeast    62 GPILYNRLKDYLIQKLALLRETIVKDNTHDYEFLGTMARLWEVQCHCFKITGDLMMYMDKVYCKP 126

  Fly   138 RECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQ-GKLINR--SLVRDVIECY 199
            ..|.|       :|.:.|..::..:.|..:..:..|::..||..|. |.:.:.  ||.:.:|...
Yeast   127 NRCME-------VYDMCLDLFRIEILQKCSSSLISALISDIERIRNLGSVDSEHTSLWKVLIGMM 184

  Fly   200 VELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQ 264
            ..|..|.:         |.:..:||...|:.|..:|.|..|        .|.|..:|:.  |:.:
Yeast   185 ETLHDNRD---------SFFLTDFEPVLISATEEYYNKAID--------IELLTPIESL--EKIR 230

  Fly   265 RVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLK-IFHTEFQNLLNADRNDDLKRMYSLVALS 328
            ::|.|.|....|:|:..:.:.||:..|.|||...|. |........:.......|:.:|.|.:..
Yeast   231 KLRQFESMLDSSFLNVDSHNKLKTVLENVLIWGKLSDIIEDLTHEAMVISNGKLLQEIYDLSSEE 295

  Fly   329 SKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYV-QTILDV-------HKKYNAL----- 380
            ...:|.::||                         |:|: :..:::       .|..||:
Yeast   296 KYRVTVIESI-------------------------KSYINKNAINIPFNEGNRKKGQNAITWSSE 335

  Fly   381 VLTAFNNDNGFVAALDKACGKFIN-----SNVVT-------IANSASKSPELLAKYCDLLLKKS- 432
            ::..:.:.:.|:.::|....:..|     ||.:.       .:...:...|.|:.|.|..:|::
Yeast   336 IVELYRSQHSFLESIDFGSVRLNNLTGDVSNAILGDVFSMYFSKEGALPSEYLSTYVDHCMKRTK 400

  Fly   433 SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGY 497
            .|:.|..:::.:|.....:...:.:||:|:|.|.|.|::||:...|.. :.|..|:..:|:..|.
Yeast   401 EKDAEIVKIKQDLLDSTKLIGLLTEKDIFEKIYKKQLSRRLLQQRSLV-EIEKWMVQMIKKVLGT 464

  Fly   498 EYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSN----NFLLPSE 558
            .:|.||:.|.:||.:|.::...|:.  :..|....:.|..:||:..|||||.:|    ...||..
Yeast   465 FFTSKLEIMLRDISLSSEMYQAFQH--STINSIEYLSFAPQVLTRTSWPFQSTNPIDEGISLPPR 527

  Fly   559 LERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSF 623
            :.:.:..|..:|:.::..|.|.|.:.:...|:....   ||..|.:..|.:...:.|.|.|....
Yeast   528 MSQILAGFEGYYSLKYKERVLKWAHHLSVIEIGCQF---NSGYYEISFSVYAGVIFLLFEDYEEL 589

  Fly   624 TVQQLQDNTQ---TQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRIN-INQ 684
            |:.::.:.|.   ...::|:..:..:.:.|:|..|.:..::  :.:|..|....|:|.::. |..
Yeast   590 TLGEIYELTHIPIDDVKSLVMSMSTIPRCKILKKSSSSGNM--KFSVNYFFSSPNRKVKVPVIAC 652

  Fly   685 PLKTELKVEQETVHKHIEEDRKLLIQ--AAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVI 747
            ||.::......|.......|.:::::  |.||||||...:|:|..|:.....:..:|......::
Yeast   653 PLPSQKSDNLATASSVDTYDNEIVMELSAIIVRIMKTEGKLSHQQLLERTTKRTQSRLSLTPSIL 717

  Fly   748 KKCIDILIEKEYLERMEGHKDTYSYLA 774
            |:.|.:||||||::|.......|.||:
Yeast   718 KRSIQLLIEKEYIQRNADDPSYYHYLS 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	132/632 (21%)
		CULLIN	454..593	CDD:214545	40/142 (28%)
		Cullin_Nedd8	701..765	CDD:214883	21/65 (32%)
CUL3	NP_011517.1	COG5647	1..744	CDD:227934	162/740 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820