DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and CDC53

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_010150.1	Gene:	CDC53 / 851424	SGDID:	S000002290	Length:	815	Species:	Saccharomyces cerevisiae

Alignment Length:	847	Identity:	252/847 - (29%)
Similarity:	426/847 - (50%)	Gaps:	112/847 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SQTTQKLVNLDDIWSELVEGIMQVFEHEKS-----------LTRSQYMRFYTHVYDYCTSVSAAP 60
            |:|..:..:|:..|:.:..||.|:..:||:           |:.:.||..||.:|:||.:.|
Yeast     2 SETLPRSDDLEATWNFIEPGINQILGNEKNQASTSKRVYKILSPTMYMEVYTAIYNYCVNKS--- 63

  Fly    61 SGRSSG------KTGGAQ-LVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQ 118
              ||||      :||.:. |||.::|::|:.:||:|    :..||. |..|..|..|.|:||.:.
Yeast    64 --RSSGHFSTDSRTGQSTILVGSEIYEKLKNYLKNY----ILNFKQ-SNSETFLQFYVKRWKRFT 121

  Fly   119 FSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQ 183
            ..:..|:...:|:||.||::|..:|::.|:.:..|.|:.||..:|....:.:...:|..:...|:
Yeast   122 IGAIFLNHAFDYMNRYWVQKERSDGKRHIFDVNTLCLMTWKEVMFDPSKDVLINELLDQVTLGRE 186

  Fly   184 GKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTV 248
            |::|.||.:...|:..|.|..:.:  |.::..|:||.|.||..|:..|..:|.:.::.:|..::|
Yeast   187 GQIIQRSNISTAIKSLVALGIDPQ--DLKKLNLNVYIQVFEKPFLKKTQEYYTQYTNDYLEKHSV 249

  Fly   249 TEYL--KHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLN 311
            |||:  .|...:.||:...:          |..:.|...|.....:|||..|::....||..||:
Yeast   250 TEYIFEAHEIIKREEKAMTI----------YWDDHTKKPLSMALNKVLITDHIEKLENEFVVLLD 304

  Fly   312 ADRNDDLKRMYSLVALSSKNLT---DLKSILENHILHQGTEAIAKCCTTDAAN------------ 361
            |   .|::::.||.||..::.|   .:.|:.||::...|...|:........|
Yeast   305 A---RDIEKITSLYALIRRDFTLIPRMASVFENYVKKTGENEISSLLAMHKHNIMKNENANPKKL 366

  Fly   362 --------DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTI-----ANS 413
                    .||.|::.:|:||..::.:...:|.:|.....|||.|||.|||.|...:     .::
Yeast   367 ALMTAHSLSPKDYIKKLLEVHDIFSKIFNESFPDDIPLAKALDNACGAFININEFALPAGSPKSA 431

  Fly   414 ASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTS 478
            .||:.|:||||.|:||||::|.....::.|  ..::.:|||:.|||.|:.:|.::.||||::.||
Yeast   432 TSKTSEMLAKYSDILLKKATKPEVASDMSD--EDIITIFKYLTDKDAFETHYRRLFAKRLIHGTS 494

  Fly   479 ASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIE----- 538
            .|.:.|..:|.:|:.....|||.|:.:|||||.:||.|...|.  :|.||   |.|:...
Yeast   495 TSAEDEENIIQRLQAANSMEYTGKITKMFQDIRLSKILEDDFA--VALKN---EPDYSKAKYPDL 554

  Fly   539 ---VLSSGSWPFQLSN-NFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNS 599
               ||:...|||.... .|.||.||..|..:..|.|:.:|:||.|.||:.:|:|||..::.:...
Yeast   555 QPFVLAENMWPFSYQEVEFKLPKELVPSHEKLKESYSQKHNGRILKWLWPLCRGELKADIGKPGR 619

  Fly   600 STYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAKVL--TSSDNENSLT 662
            ..:....:.|||::||.:||....|::.:|:.|....:::...:...:|.|::  .....:..:.
Yeast   620 MPFNFTVTLFQMAILLLYNDADVLTLENIQEGTSLTIQHIAAAMVPFIKFKLIQQVPPGLDALVK 684

  Fly   663 PESTVELFLDYKNKKRRININQPLKTEL--------------------KVEQETVHKHIEEDRKL 707
            ||:..:|...||..|..||....:|.::                    ..|.|.:.|.:..:|::
Yeast   685 PETQFKLSRPYKALKTNINFASGVKNDILQSLSGGGHDNHGNKLGNKRLTEDERIEKELNTERQI 749

  Fly   708 LIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSY 772
            .::|.||||||.::.|.||.|::|.:.|...||..||.::|:.||.||:|.||:|.: ..::|:|
Yeast   750 FLEACIVRIMKAKRNLPHTTLVNECIAQSHQRFNAKVSMVKRAIDSLIQKGYLQRGD-DGESYAY 813

  Fly   773 LA 774
            ||
Yeast   814 LA 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	207/706 (29%)
		CULLIN	454..593	CDD:214545	57/147 (39%)
		Cullin_Nedd8	701..765	CDD:214883	27/63 (43%)
CDC53	NP_010150.1	COG5647	7..815	CDD:227934	248/840 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346096
Domainoid	1	1.000	309	1.000	Domainoid score	I206
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I352
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	1	1.000	-	-		otm46807
orthoMCL	1	0.900	-	-		OOG6_101330
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R262
SonicParanoid	1	1.000	-	-		X1841
TreeFam	1	0.960	-	-
	14	13.790