Protein Alignment Cul1 and CUL1

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_003583.2
• Gene: CUL1 / 8454
• HGNCID: 2551
• Length: 776
• Species: Homo sapiens
• Alignment Length: 779
• Identity: 489/779 - (62%)
• Similarity: 595/779 - (76%)
• Gaps: 31/779 - (3%)

  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSV---------SAAPSGRSSGK 67
            |.:.||.||.:|..||.||:..: |:.:|:||..|||||:|||||         ...||....|:
Human    13 KQIGLDQIWDDLRAGIQQVYTRQ-SMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQ 76

  Fly    68 T-GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYL 131
            | ||||.||.:||.||::|||:||:.||...:.:..|.| |..||:||:.|:|||.||:|||.||
Human    77 TPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNGICAYL 140

  Fly   132 NRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVI 196
            ||:||:|||:||:||||:||.||||.|:..||:.||:.||.||||.||:||.|:.||..|:..|:
Human   141 NRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVV 205

  Fly   197 ECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEE 261
            :.||||..||:|..|:...|:|||::||::|:|||..||.:||..||..|.||||:|..|.||.|
Human   206 QSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLE 270

  Fly   262 ETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVA 326
            |.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:|:||.|||:||:
Human   271 EQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVS 327

  Fly   327 LSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGF 391
            .....|.:||.:||.||.:||..||.||... |.||||.||||:|||||||||||::|||||.||
Human   328 RIQDGLGELKKLLETHIHNQGLAAIEKCGEA-ALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGF 391

  Fly   392 VAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYI 455
            |||||||||:|||:|.|| :|.|:||||||||:|||.||||||||||:.||||.|||||||||||
Human   392 VAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYI 456

  Fly   456 EDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYF 520
            ||||||||:|:||||||||:..||||||||.|||||||.||:|||.||||||||||||||||..|
Human   457 EDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQF 521

  Fly   521 KQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQM 585
            |::|.... .:::||.|:||||||||||.|..|.||||||||.::|..|||:|||||||.||||:
Human   522 KKHLTNSE-PLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQL 585

  Fly   586 CKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK 650
            .||||:.|..:|.   ||||||||||::|||:|.:.::|||||.|:||.:.:.|.||||||||:|
Human   586 SKGELVTNCFKNR---YTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSK 647

  Fly   651 VLTSSD-----NENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQ 710
            :|...|     :|..|.|::.::|:|.|||||.|:|||.|:|||.|.||||.||:||||||||||
Human   648 LLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQ 712

  Fly   711 AAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |||||||||||.|.|..|:.|||.|||:||||:|||||||||||||||||||::|.||||||||
Human   713 AAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	403/668 (60%)
		Cullin_Nedd8	704..765	CDD:463146	50/60 (83%)
CUL1	NP_003583.2	Cullin	21..660	CDD:459983	398/653 (61%)
		Cullin_Nedd8	706..768	CDD:463146	50/61 (82%)