DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and CUL2

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_011518045.1	Gene:	CUL2 / 8453	HGNCID:	2552	Length:	808	Species:	Homo sapiens

Alignment Length:	785	Identity:	269/785 - (34%)
Similarity:	438/785 - (55%)	Gaps:	67/785 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGK 76
            ::|:.|:.|::|:..|..|...| .:.|:.:...::.:|..|.   |.|           :.:|:
Human    69 RVVDFDETWNKLLTTIKAVVMLE-YVERATWNDRFSDIYALCV---AYP-----------EPLGE 118

  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKR--- 138
            :||...:.||::::..|  ..:.:..||.:|..|.:.|:.|...:..:|.:..|||..::|:
Human   119 RLYTETKIFLENHVRHL--HKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKL 181

  Fly   139 ---ECEEGQKGI------YKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRD 194
               :.:.|..|:      .:|..|||..|:..:.:.|...:.:.:|:.|:.:|.|:..|:.::..
Human   182 TEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHG 246

  Fly   195 VIECYVELSFNEEDTDAEQQK----LSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHV 255
            ||..:|.:         ||.|    |..|::.||:.|:.:|..:|::|:...|..:..::|::.|
Human   247 VINSFVHV---------EQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKV 302

  Fly   256 ENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKR 320
            ..||::|..|.|        .|||.::...:...|::.::..||:..|.|..|::..::.:|:..
Human   303 LGRLKDEEIRCR--------KYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMAN 359

  Fly   321 MYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAF 385
            ||.|:...|..|..:...|:|||..:|..|.:   .....|.|..:|:::|:||.|:..|:.|..
Human   360 MYVLLRAVSTGLPHMIQELQNHIHDEGLRATS---NLTQENMPTLFVESVLEVHGKFVQLINTVL 421

  Fly   386 NNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMV 450
            |.|..|::|||||....:|...   ..|..|:|||||||||.|||||:|...:.|:||.|...:.
Human   422 NGDQHFMSALDKALTSVVNYRE---PKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT 483

  Fly   451 VFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKD 515
            |||||:|||||||:|::||||||::..|.|.|:|..||:||||.||||:|.||.||:.|:.||.|
Human   484 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSAD 548

  Fly   516 LNSYFKQYLAEKNLTMEIDFGIE----VLSSGSWPFQL--SNNFLLPSELERSVRQFNEFYAARH 574
            ||:.|..::  ||....||.||.    ||.:|:||...  |:.|.:|.|||:||:.|..||:...
Human   549 LNNKFNNFI--KNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHF 611

  Fly   575 SGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENL 639
            |||||.||:.:|.||:.||.   ....|....:|:||:|||.||:..:.:.::|||:||..::.|
Human   612 SGRKLTWLHYLCTGEVKMNY---LGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKEL 673

  Fly   640 IQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704
            .:.::.||..|::.....:..:..||:..|.:::.:|:.:..|...::.:...|.|.....::||
Human   674 TKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDED 738

  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769
            ||:.:|||||||||.||.|.|..||.||::|...||.|.:.:|||||::||:|:|:||.:...|.
Human   739 RKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADE 803

  Fly   770 YSYLA 774
            |||:|
Human   804 YSYVA 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	220/669 (33%)
		CULLIN	454..593	CDD:214545	74/144 (51%)
		Cullin_Nedd8	701..765	CDD:214883	36/63 (57%)
CUL2	XP_011518045.1	Cullin	93..706	CDD:279260	217/656 (33%)
		CULLIN	487..631	CDD:214545	75/145 (52%)
		Cullin_Nedd8	735..802	CDD:214883	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830