Protein Alignment Cul1 and CUL3

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001244127.1
• Gene: CUL3 / 8452
• HGNCID: 2553
• Length: 774
• Species: Homo sapiens
• Alignment Length: 812
• Identity: 230/812 - (28%)
• Similarity: 397/812 - (48%)
• Gaps: 118/812 - (14%)

  Fly    11 QKLVNLDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHVYDYCTSVSAAPSGRSSGKT 68
            :|.||  .||..|...|.::.....|      |.|:.| |..:.|
Human    33 EKYVN--SIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKH-------------------- 75

  Fly    69 GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLDG 126
                  |:|||..|.:.:..:   |:.|.:    |:||       |....:.|..:|.:..::..
Human    76 ------GEKLYTGLREVVTEH---LINKVR----EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRD 127

  Fly   127 ICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLINR 189
            |..|::|.:|:      |..:..:|.|.|:.::..:  :..:.:.:.:.:|..|..||:|::::|
Human   128 ILMYMDRVYVQ------QNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR 186

  Fly   190 SLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKH 254
            ..:|:..:..:.|..         :..|||:::||..|:..::.|::.||..||:.|:.:.|:|.
Human   187 GAIRNACQMLMILGL---------EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 242

  Fly   255 VENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNADR 314
            ||.|:.||.:||        :..|.::|.:.:....|..||.||:|.. .|.:|     :|...:
Human   243 VEARINEEIERV--------MHCLDKSTEEPIVKVVERELISKHMKTI-VEMENSGLVHMLKNGK 298

  Fly   315 NDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNA 379
            .:||..||.|.:.....|..:...:.:::..||...:::   .....:|..|:|.:||:..:::.
Human   299 TEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSE---EGEGKNPVDYIQGLLDLKSRFDR 360

  Fly   380 LVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDN 444
            .:|.:||||..|...:......|:|.|        |:|||.|:.:.|..|||..|...::|:|..
Human   361 FLLESFNNDRLFKQTIAGDFEYFLNLN--------SRSPEYLSLFIDDKLKKGVKGLTEQEVETI 417

  Fly   445 LNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQD 509
            |::.||:|:::::||||::||.:.||:||:.:.|.|||:|..||||||..||.::|.||:.||:|
Human   418 LDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRD 482

  Fly   510 IGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFYAA 572
            :.:|......|:|:|....::: .:|..:.||::|.||.|.:. ...:|.....:...|..||.|
Human   483 MSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLA 547

  Fly   573 RHSGRKLNWLYQMCKGELI-------------------MNVNRNNSSTYTLQASTFQMSVLLQFN 618
            :||||:|...:.|...:|.                   ..|..:|:..:.||.|||||::|:.||
Human   548 KHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN 612

  Fly   619 DQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFLDYKNKKRR 679
            ::..:|.:::|..|...:..|::.||.|...|    |||.......:.......:...:.:|..|
Human   613 NREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHR 677

  Fly   680 ININ--QPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
            :.|.  ...:.|...|::...:.:::|||..|:||||||||.||::.|..|::||..||..||.|
Human   678 VKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLP 742

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...||||.|:.|||:|||.|....:..|:|:|
Human   743 SPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	182/693 (26%)
		CULLIN	454..593	CDD:214545	52/159 (33%)
		Cullin_Nedd8	701..765	CDD:214883	35/63 (56%)
CUL3	NP_001244127.1	Cullin	41..670	CDD:279260	182/696 (26%)
		CULLIN	427..569	CDD:214545	52/141 (37%)
		Cullin_Nedd8	706..766	CDD:287520	33/59 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830