Protein Alignment Cul1 and CUL4A

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001008895.1
• Gene: CUL4A / 8451
• HGNCID: 2554
• Length: 759
• Species: Homo sapiens
• Alignment Length: 765
• Identity: 233/765 - (30%)
• Similarity: 367/765 - (47%)
• Gaps: 74/765 - (9%)

  Fly    18 DIWSELVEGIMQVFEHEKSLTRSQY--MRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |.|.:|.|.:..|    :|.|..:|  ...|..|.:.|                 :..|...||.
Human    61 DTWRKLHEAVRAV----QSSTSIRYNLEELYQAVENLC-----------------SHKVSPMLYK 104

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:..|:..|.:.|| |.:....|:.:.....::..|..:|:|.:|.:     .
Human   105 QLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ-----N 164

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  :::.......:|..||.||.|:.::|||:|.::....:
Human   165 STLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSD------ 223

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.|||.:||.||:.:|:..|..|....:....|.|||.||..|||||..||
Human   224 --------LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRV------ 274

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||..:|...|.:..|:.|:.:|| .|......:||:.:|..||.:||.|.:........|.
Human   275 --ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALL 337

  Fly   337 SILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGK 401
            .....:|...||..:..      ....|..||.:||...|.:.::...|..:..||..:.::...
Human   338 QHWSEYIKTFGTAIVIN------PEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFET 396

  Fly   402 FINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYS 466
            |||..       .:|..||:||:.|..|:..:|...|:|||..|:::|::|::|..||||:.:|.
Human   397 FINKR-------PNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYK 454

  Fly   467 KMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTM 531
            |.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:..:|||::..::.:.
Human   455 KDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSG 519

  Fly   532 EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNR 596
            .||..:.:|:.|.||........|..|:.:....|..||..:||||||.|  |...|..::....
Human   520 PIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQW--QTTLGHAVLKAEF 582

  Fly   597 NNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDNEN 659
            ..... ..|.|.||..|||.||:...|:.::::..|..:...|.:.||.|.  ||:||..|....
Human   583 KEGKK-EFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGK 646

  Fly   660 SLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLN 724
            .:..........::|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||||.|.
Human   647 EVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLG 711

  Fly   725 HTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |..|:||:.|||  :|..|...:||.|:.||:::|:||.:.:.:.|.|:|
Human   712 HNLLVSELYNQL--KFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	187/660 (28%)
		Cullin_Nedd8	704..765	CDD:463146	32/60 (53%)
CUL4A	NP_001008895.1	Cullin	63..660	CDD:459983	187/660 (28%)
		Cullin_Nedd8	688..753	CDD:214883	32/66 (48%)