Protein Alignment Cul1 and CUL4B

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_003579.3
• Gene: CUL4B / 8450
• HGNCID: 2555
• Length: 913
• Species: Homo sapiens
• Alignment Length: 767
• Identity: 241/767 - (31%)
• Similarity: 383/767 - (49%)
• Gaps: 76/767 - (9%)

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCT-SVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |:.|.:|.|.: :..::..|: :......|..|.:.|: .:||                  .||.
Human   214 DETWQKLKEAV-EAIQNSTSI-KYNLEELYQAVENLCSYKISA------------------NLYK 258

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:.:|:..|.:.|| |.:..:.|:::.....::..|..:|:|.:|.:     .
Human   259 QLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ-----N 318

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  |.:.......:|..||.||.|:.|:|||:|.::....:
Human   319 SMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD------ 377

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.:|:.:||.:|:.:|:..|..|....:....|.|||.||..|||||..|:
Human   378 --------LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRL------ 428

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||.:||...|.:|.|:.|:.:|| .|......|||:.:|..||..:|.|.:.....:..|
Human   429 --ITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVL- 490

  Fly   337 SILENHILHQGTEAIAKCCTTDAAN--DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKAC 399
                   |.|..|.|....:|...|  ..||.||.:||...|.:.::...|..:..|:.|:.:|.
Human   491 -------LQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAF 548

  Fly   400 GKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKY 464
            ..|||..       .:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:
Human   549 ETFINKR-------PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 606

  Fly   465 YSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNL 529
            |.|.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:...||||:..:|:
Human   607 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNV 671

  Fly   530 TMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNV 594
            ...|:..:.:|:.|.||..:.....||.|:.:....|..||..:||||||.|  |...|..::..
Human   672 PGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQW--QSTLGHCVLKA 734

  Fly   595 NRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDN 657
            ....... .||.|.||..|||.||:...|::::::..|..:...|.:.||.|.  ||:||..:..
Human   735 EFKEGKK-ELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPK 798

  Fly   658 ENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKR 722
            ...:..........|:|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||||.
Human   799 GKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKT 863

  Fly   723 LNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |:|..|:|||.|||  :|..|...:||.|:.||:::|:||.:.:.:.|:|:|
Human   864 LSHNLLVSEVYNQL--KFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	193/661 (29%)
		Cullin_Nedd8	704..765	CDD:463146	33/60 (55%)
CUL4B	NP_003579.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:19801544	55..58
		Cullin	217..814	CDD:459983	193/661 (29%)
		Cullin_Nedd8	842..907	CDD:214883	33/66 (50%)