Protein Alignment Cul1 and CUL2

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_171797.2
• Gene: CUL2 / 839415
• AraportID: AT1G02980
• Length: 742
• Species: Arabidopsis thaliana
• Alignment Length: 785
• Identity: 219/785 - (27%)
• Similarity: 387/785 - (49%)
• Gaps: 84/785 - (10%)

  Fly    20 WSELVEG------IMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            ||.:..|      |::....|......|.|:.||.|::.||  ...|:..|           :::
plant    12 WSVMEAGVAKLQKILEEVPDEPPFDPVQRMQLYTTVHNLCT--QKPPNDYS-----------QQI 63

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGE--EVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECE 141
            |||.......|..:  |...||..:  |.:|....|:|.:.:.....|.....||:|.:.:|...
plant    64 YDRYGGVYVDYNKQ--TVLPAIREKHGEYMLRELVKRWANQKILVRWLSHFFEYLDRFYTRRGSH 126

  Fly   142 EGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNE 206
            .      .:..:..::::..::|.|......|||..|.:||:|:.|:|:|:::||:.|......|
plant   127 P------TLSAVGFISFRDLVYQELQSKAKDAVLALIHKEREGEQIDRALLKNVIDVYCGNGMGE 185

  Fly   207 EDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNS 271
                     |..|:::||:..:.|::::|.:.:..:...|:..:|:...|..|..|.:||
plant   186 ---------LVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEKERV----- 236

  Fly   272 KNGLSYLHETTADVLKSTCEE---VLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNL 332
               .:|||.||...|.:..:.   |::.|.| :..|:..:.||..|:.|||.|||.|.....:.|
plant   237 ---TNYLHSTTEPKLVAKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYRLYHPIPQGL 298

  Fly   333 TDLKSILENHILHQGTEAIAKCCTTDAAND-----------PKTYVQTILDVHKKYNALVLTAFN 386
            ..:..:.:.||..:|:..|.:  .|:||.|           .:..::.::|:|.|:...|...|.
plant   299 DPVADLFKQHITVEGSALIKQ--ATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDECFQ 361

  Fly   387 NDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSS--KNPEDKELEDNLNQVM 449
            ..:.|..||.:|...|.|..|..::     |.|:||.|||.:||...  :..|:::||..|.:|:
plant   362 KHSLFHKALKEAFEVFCNKTVAGVS-----SAEILATYCDNILKTGGGIEKLENEDLELTLEKVV 421

  Fly   450 VVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSK 514
            .:..||.|||:|.:::.|..|:||:...:.:|..|..:::|.|:..|.::|.|::.|..|:.::|
plant   422 KLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAK 486

  Fly   515 DLNSYFKQYLA-EKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRK 578
            :..:.|.::|: .|...:.:||.:.||::|.||...:.:..||.|:...|..|..:|..:.:.|:
plant   487 EHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRR 551

  Fly   579 LNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN--DQLSFTVQQLQDNTQTQQENLIQ 641
            |:|:|.:...:|   ..:.:..|..:..:|:|.:|||.||  ::||:|  ::.:......|:|.:
plant   552 LSWIYSLGTCQL---AGKFDKKTIEIVVTTYQAAVLLLFNNTERLSYT--EILEQLNLGHEDLAR 611

  Fly   642 VLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704
            :|..|  ||.|:|.......:::...|.|....:.:|.|||.:..|...|.|    .:.:.:::|
plant   612 LLHSLSCLKYKILIKEPMSRNISNTDTFEFNSKFTDKMRRIRVPLPPMDERK----KIVEDVDKD 672

  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769
            |:..|.||:|||||.||.|.|..|:||.:..||..|||.:.:|||.|:.||.::||||...:.:|
plant   673 RRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLERDTDNPNT 737

  Fly   770 YSYLA 774
            :.|||
plant   738 FKYLA 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	176/682 (26%)
		Cullin_Nedd8	704..765	CDD:463146	32/60 (53%)
CUL2	NP_171797.2	Cullin	12..645	CDD:459983	176/682 (26%)
		RMtype1_S_TRD-CR_like	<641..689	CDD:365779	17/51 (33%)
		Cullin_Nedd8	672..734	CDD:463146	32/61 (52%)