DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and CUL2

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001318910.1	Gene:	CUL2 / 839415	AraportID:	AT1G02980	Length:	742	Species:	Arabidopsis thaliana

Alignment Length:	785	Identity:	219/785 - (27%)
Similarity:	387/785 - (49%)	Gaps:	84/785 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WSELVEG------IMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            ||.:..|      |::....|......|.|:.||.|::.||  ...|:..|           :::
plant    12 WSVMEAGVAKLQKILEEVPDEPPFDPVQRMQLYTTVHNLCT--QKPPNDYS-----------QQI 63

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGE--EVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECE 141
            |||.......|..:  |...||..:  |.:|....|:|.:.:.....|.....||:|.:.:|...
plant    64 YDRYGGVYVDYNKQ--TVLPAIREKHGEYMLRELVKRWANQKILVRWLSHFFEYLDRFYTRRGSH 126

  Fly   142 EGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNE 206
            .      .:..:..::::..::|.|......|||..|.:||:|:.|:|:|:::||:.|......|
plant   127 P------TLSAVGFISFRDLVYQELQSKAKDAVLALIHKEREGEQIDRALLKNVIDVYCGNGMGE 185

  Fly   207 EDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNS 271
                     |..|:::||:..:.|::::|.:.:..:...|:..:|:...|..|..|.:||
plant   186 ---------LVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEKERV----- 236

  Fly   272 KNGLSYLHETTADVLKSTCEE---VLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNL 332
               .:|||.||...|.:..:.   |::.|.| :..|:..:.||..|:.|||.|||.|.....:.|
plant   237 ---TNYLHSTTEPKLVAKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYRLYHPIPQGL 298

  Fly   333 TDLKSILENHILHQGTEAIAKCCTTDAAND-----------PKTYVQTILDVHKKYNALVLTAFN 386
            ..:..:.:.||..:|:..|.:  .|:||.|           .:..::.::|:|.|:...|...|.
plant   299 DPVADLFKQHITVEGSALIKQ--ATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDECFQ 361

  Fly   387 NDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSS--KNPEDKELEDNLNQVM 449
            ..:.|..||.:|...|.|..|..::     |.|:||.|||.:||...  :..|:::||..|.:|:
plant   362 KHSLFHKALKEAFEVFCNKTVAGVS-----SAEILATYCDNILKTGGGIEKLENEDLELTLEKVV 421

  Fly   450 VVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSK 514
            .:..||.|||:|.:::.|..|:||:...:.:|..|..:::|.|:..|.::|.|::.|..|:.::|
plant   422 KLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAK 486

  Fly   515 DLNSYFKQYLA-EKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRK 578
            :..:.|.::|: .|...:.:||.:.||::|.||...:.:..||.|:...|..|..:|..:.:.|:
plant   487 EHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRR 551

  Fly   579 LNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN--DQLSFTVQQLQDNTQTQQENLIQ 641
            |:|:|.:...:|   ..:.:..|..:..:|:|.:|||.||  ::||:|  ::.:......|:|.:
plant   552 LSWIYSLGTCQL---AGKFDKKTIEIVVTTYQAAVLLLFNNTERLSYT--EILEQLNLGHEDLAR 611

  Fly   642 VLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704
            :|..|  ||.|:|.......:::...|.|....:.:|.|||.:..|...|.|    .:.:.:::|
plant   612 LLHSLSCLKYKILIKEPMSRNISNTDTFEFNSKFTDKMRRIRVPLPPMDERK----KIVEDVDKD 672

  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769
            |:..|.||:|||||.||.|.|..|:||.:..||..|||.:.:|||.|:.||.::||||...:.:|
plant   673 RRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLERDTDNPNT 737

  Fly   770 YSYLA 774
            :.|||
plant   738 FKYLA 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	174/677 (26%)
		CULLIN	454..593	CDD:214545	41/139 (29%)
		Cullin_Nedd8	701..765	CDD:214883	32/63 (51%)
CUL2	NP_001318910.1	Cullin	12..645	CDD:366357	176/682 (26%)
CUL2	NP_001318910.1	Cullin_Nedd8	669..736	CDD:214883	32/66 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101330
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1841
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730