DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and CUL3

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_174005.1	Gene:	CUL3 / 839226	AraportID:	AT1G26830	Length:	732	Species:	Arabidopsis thaliana

Alignment Length:	773	Identity:	237/773 - (30%)
Similarity:	397/773 - (51%)	Gaps:	81/773 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDR 81
            |..|..|...|.|::..:.|  ...:...|.:.|:..                 ....|:|||..
plant    26 DKTWQILERAIHQIYNQDAS--GLSFEELYRNAYNMV-----------------LHKFGEKLYTG 71

  Fly    82 LEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKG 146
            ....:.|:|.|.....:|..|.. .|....|:|..:..:..::..|..|::|.::     |..|.
plant    72 FIATMTSHLKEKSKLIEAAQGGS-FLEELNKKWNEHNKALEMIRDILMYMDRTYI-----ESTKK 130

  Fly   147 IYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDT 209
            .: ::.:.|..|:.::  |..::..:...:|..:::||.|::|:|.|:|:||:.:::|.
plant   131 TH-VHPMGLNLWRDNVVHFTKIHTRLLNTLLDLVQKERIGEVIDRGLMRNVIKMFMDLG------ 188

  Fly   210 DAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNG 274
                  .|||:::||..|:..:|.||:.||..|:.:....:|||..|.||.||.:||
plant   189 ------ESVYQEDFEKPFLDASSEFYKVESQEFIESCDCGDYLKKSEKRLTEEIERV-------- 239

  Fly   275 LSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNA---DRNDDLKRMYSLVALSSKNLTDL 335
            ..||...:.:.:.|..|:.:|..|: ::.|.|...|:|.   |:.:||.|||:|....:..|..:
plant   240 AHYLDAKSEEKITSVVEKEMIANHMQRLVHMENSGLVNMLLNDKYEDLGRMYNLFRRVTNGLVTV 304

  Fly   336 KSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACG 400
            :.::.:|:...|.:.:.   ..:.:.||..:||.:||...||:.::.|||.||..|..||:.:..
plant   305 RDVMTSHLREMGKQLVT---DPEKSKDPVEFVQRLLDERDKYDKIINTAFGNDKTFQNALNSSFE 366

  Fly   401 KFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYY 465
            .|||.|        ::|||.::.:.|..|:|..|...|.::|..|::||::|:|:::||||:|||
plant   367 YFINLN--------ARSPEFISLFVDDKLRKGLKGITDVDVEVILDKVMMLFRYLQEKDVFEKYY 423

  Fly   466 SKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLT 530
            .:.|||||::..:.|||||..:|.|||..|||::|.||:.||.|:..|:|....|  |.:...|:
plant   424 KQHLAKRLLSGKTVSDDAERSLIVKLKTECGYQFTSKLEGMFTDMKTSEDTMRGF--YGSHPELS 486

  Fly   531 MEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVN 595
            ......::||::||||.|.:....||:|:.....:|..:|...|:||:|:|...|  |...:...
plant   487 EGPTLIVQVLTTGSWPTQPAVPCNLPAEVSVLCEKFRSYYLGTHTGRRLSWQTNM--GTADIKAI 549

  Fly   596 RNNSSTYTLQASTFQMSVLLQFN--DQLSFTVQQLQDNTQTQQENLIQVLQIL--LKAK-VLTSS 655
            ......:.|..|||||.||:.||  |:||:  ::::..|:....:|.:.||.|  :|.| |:...
plant   550 FGKGQKHELNVSTFQMCVLMLFNNSDRLSY--KEIEQATEIPAADLKRCLQSLACVKGKNVIKKE 612

  Fly   656 DNENSLTPESTVELFL---DYKNKKRRININQPL-KTELKVEQETVHKHIEEDRKLLIQAAIVRI 716
            .....:..|   :||:   .:.:|..::.|...: :.|.:.|::...:.:|||||..|:||||||
plant   613 PMSKDIGEE---DLFVVNDKFTSKFYKVKIGTVVAQKETEPEKQETRQRVEEDRKPQIEAAIVRI 674

  Fly   717 MKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ||.||.|:|.|:|:||..||..||......|||.|:.|||:::|||....:..|.|||
plant   675 MKSRKILDHNNIIAEVTKQLQPRFLANPTEIKKRIESLIERDFLERDSTDRKLYRYLA 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	189/658 (29%)
		CULLIN	454..593	CDD:214545	55/138 (40%)
		Cullin_Nedd8	701..765	CDD:214883	36/63 (57%)
CUL3	NP_174005.1	Cullin	29..630	CDD:395716	192/666 (29%)
CUL3	NP_174005.1	Cullin_Nedd8	662..721	CDD:402267	33/58 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830