DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and CUL1

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001031575.1	Gene:	CUL1 / 825648	AraportID:	AT4G02570	Length:	738	Species:	Arabidopsis thaliana

Alignment Length:	794	Identity:	236/794 - (29%)
Similarity:	406/794 - (51%)	Gaps:	88/794 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QKLVNLDDIWSELVEGI---MQVFE--HEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGG 70
            :|.::|:..|..:..||   .::.|  :|.:....|||..||.:|:.||  ...|...|
plant     3 RKTIDLEQGWDYMQTGITKLKRILEGLNEPAFDSEQYMMLYTTIYNMCT--QKPPHDYS------ 59

  Fly    71 AQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNW 135
                 ::|||:..:..:.|::..:........:|.:|....|:|.:::.....|.....||:|.:
plant    60 -----QQLYDKYREAFEEYINSTVLPALREKHDEFMLRELFKRWSNHKVMVRWLSRFFYYLDRYF 119

  Fly   136 VKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYV 200
            :.|      :.:..:..:.|..::..::..|:..|.:||:..:::||:|:.|:|:|:::|::.||
plant   120 IAR------RSLPPLNEVGLTCFRDLVYNELHSKVKQAVIALVDKEREGEQIDRALLKNVLDIYV 178

  Fly   201 ELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQR 265
            |:...:         :..|:::||:..:.|||::|.:::.:::..::..:|:...|..|::|.:|
plant   179 EIGMGQ---------MERYEEDFESFMLQDTSSYYSRKASSWIQEDSCPDYMLKSEECLKKERER 234

  Fly   266 VRGFNSKNGLSYLHETTADVLKSTCEEVLIEK--H--LKIF--------HTEFQNLLNADRNDDL 318
            |        ..|||        |:.|..|:||  |  |.:|        |:..:.||..|:.|||
plant   235 V--------AHYLH--------SSSEPKLVEKVQHELLVVFASQLLEKEHSGCRALLRDDKVDDL 283

  Fly   319 KRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKC---CTTDAAN----DPKTYVQTILDVHKK 376
            .|||.|.....:.|..:.:|.:.|:..:|...:.:.   .|...||    ..:..::.::::|.|
plant   284 SRMYRLYHKILRGLEPVANIFKQHVTAEGNALVQQAEDTATNQVANTASVQEQVLIRKVIELHDK 348

  Fly   377 YNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKK-SSKNPEDKE 440
            |...|...|.|...|..||.:|...|.|..|     :.|.|.||||.:||.:||| .|:...|:.
plant   349 YMVYVTECFQNHTLFHKALKEAFEIFCNKTV-----AGSSSAELLATFCDNILKKGGSEKLSDEA 408

  Fly   441 LEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQR 505
            :||.|.:|:.:..||.|||:|.::|.|.||:||:...||:||.|..:::||||.||.::|.|::.
plant   409 IEDTLEKVVKLLAYISDKDLFAEFYRKKLARRLLFDRSANDDHERSILTKLKQQCGGQFTSKMEG 473

  Fly   506 MFQDIGVSKDLNSYFKQYLAEKNLTME-IDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEF 569
            |..|:.::::..:.|:.||........ ||..:.||::|.||...|.:..||||:.:.|..|..|
plant   474 MVTDLTLARENQNSFEDYLGSNPAANPGIDLTVTVLTTGFWPSYKSFDINLPSEMIKCVEVFKGF 538

  Fly   570 YAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN--DQLSFTVQQLQDNT 632
            |..:...|||.|:|.:  |...:| .:.:.....|..||:|.:|||.||  |:||:|  ::....
plant   539 YETKTKHRKLTWIYSL--GTCHIN-GKFDQKAIELIVSTYQAAVLLLFNTTDKLSYT--EILAQL 598

  Fly   633 QTQQENLIQVLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQE 695
            ....|:|:::|..|  .|.|:|....|..:::.....|....:.::.|||.|..|...|.|
plant   599 NLSHEDLVRLLHSLSCAKYKILLKEPNTKTVSQNDAFEFNSKFTDRMRRIKIPLPPVDERK---- 659

  Fly   696 TVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYL 760
            .|.:.:::||:..|.||||||||.||.|.|..|:||.:.|||..|||.:..|||.::.||.::||
plant   660 KVVEDVDKDRRYAIDAAIVRIMKSRKVLGHQQLVSECVEQLSRMFKPDIKAIKKRMEDLITRDYL 724

  Fly   761 ERMEGHKDTYSYLA 774
            ||.:.:.:.:.|||
plant   725 ERDKENPNMFRYLA 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	188/677 (28%)
		CULLIN	454..593	CDD:214545	52/139 (37%)
		Cullin_Nedd8	701..765	CDD:214883	33/63 (52%)
CUL1	NP_001031575.1	Cullin	12..641	CDD:395716	190/682 (28%)
CUL1	NP_001031575.1	Cullin_Nedd8	668..729	CDD:402267	33/60 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101330
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1841
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730