DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul5

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001072836.1	Gene:	cul5 / 780297	XenbaseID:	XB-GENE-484069	Length:	780	Species:	Xenopus tropicalis

Alignment Length:	821	Identity:	237/821 - (28%)
Similarity:	396/821 - (48%)	Gaps:	113/821 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            :..:|.|..:...::::...| |:|:.|:...::.|:..|......|:               |:
Frog    13 LQFEDKWDFMRPIVLKLLRQE-SVTKQQWFDLFSDVHAVCLWDDKGPA---------------KI 61

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECE-E 142
            :..|::.:..::.:...:..:...:..||..|..:|:.: |:.      |:.|.:.:.:.|.. .
Frog    62 HQALKEDILDFIKQAQARVLSHQDDTALLKAYIVEWRKF-FTQ------CDILPKPFCQLEITLM 119

  Fly   143 GQKGIYK--------IYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECY 199
            |::|..|        :.:|.|..|...:|..:...:..:.:|.:..||.|:..:..||..|.|.|
Frog   120 GKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESY 184

  Fly   200 VELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQ 264
            |.|..|.||      ||.:|:.|||..::..|..||..::.::|..|.|..|:|:.:.:|:||..
Frog   185 VNLCSNPED------KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEN 243

  Fly   265 RVRGFNSKNGLSYLHET-----TADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSL 324
            |        .|.|| ||     :...|...|...|:....:....|.|.::..:..:.|..|:||
Frog   244 R--------ALRYL-ETRRECNSVQALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSL 299

  Fly   325 VALSSKNLTDLKSILENHILHQGTE---AIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFN 386
            :......:..:...||.||:..|..   |.|:..|||:    :.||:.:|.:..:::.||..||.
Frog   300 MDKVPNGIEPMLKDLEEHIVSAGLADMVAAAETITTDS----EKYVEQLLTLFNRFSKLVKEAFQ 360

  Fly   387 NDNGFVAALDKACGKFINSNVVTI---------------ANSASKSPELLAKYCDLLLKKS--SK 434
            :|..|:.|.|||....:|.  .||               ....||.|||||.|||:||:|:  ||
Frog   361 DDPRFLTARDKAYKAVVND--ATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSK 423

  Fly   435 NPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQT-CGYE 498
            ....:|:|..|.:|::|.||:::||||.:|:...|.:||:...||..:.|..|:..|::. ...:
Frog   424 KLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPAD 488

  Fly   499 YTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEID-FGIEVLSSGSWPFQLSNNFL-LPSELER 561
            |..||.||||||.||:|||..||:......|.:..| ..|::|::|:|.......|: ||:|||.
Frog   489 YVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELED 553

  Fly   562 SVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN----DQLS 622
            .:.:..|||...||||||:|.:.|..|.:..   :|....|.|:.:|||::||..:|    :::|
Frog   554 LIPEVEEFYKKNHSGRKLHWHHLMSNGIITF---KNEVGQYDLEVTTFQLAVLFAWNQRPREKIS 615

  Fly   623 FTVQQLQDNTQTQQENLIQVLQIL-----LKAKVLTSSDNENSLTPESTVE-----------LFL 671
            |  :.|:..|:.....|.:.|..|     ||.:||:.....||  |:...|           |..
Frog   616 F--ENLKLATELPDAELRRTLWSLVAFPKLKRQVLSYEPTVNS--PKDFTEGTLFSVNQEFSLIK 676

  Fly   672 DYKNKKR-RINI--NQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVL 733
            :.|.:|| :||:  ...|.||...|:|  ::.|.:.|.|..|.||::||||||::.:..|.:|::
Frog   677 NGKVQKRGKINLIGRLQLTTERMREEE--NEGIVQLRILRTQEAIIQIMKMRKKITNAQLQTELV 739

  Fly   734 NQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ..|...|.|:..:||:.|:.|||.:|::|.|...:|:.|:|
Frog   740 EILKNMFLPQKKMIKEQIEWLIEHKYIKRDESDINTFIYMA 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	195/704 (28%)
		CULLIN	454..593	CDD:214545	54/141 (38%)
		Cullin_Nedd8	701..765	CDD:214883	25/63 (40%)
cul5	NP_001072836.1	Cullin	19..672	CDD:366357	196/703 (28%)
cul5	NP_001072836.1	Cullin_Nedd8	713..770	CDD:371133	23/56 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010