Protein Alignment Cul1 and cul5

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001072836.1
• Gene: cul5 / 780297
• XenbaseID: XB-GENE-484069
• Length: 780
• Species: Xenopus tropicalis
• Alignment Length: 821
• Identity: 237/821 - (28%)
• Similarity: 396/821 - (48%)
• Gaps: 113/821 - (13%)

  Fly    14 VNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            :..:|.|..:...::::...| |:|:.|:...::.|:..|......|:               |:
 Frog    13 LQFEDKWDFMRPIVLKLLRQE-SVTKQQWFDLFSDVHAVCLWDDKGPA---------------KI 61

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECE-E 142
            :..|::.:..::.:...:..:...:..||..|..:|:.: |:.      |:.|.:.:.:.|.. .
 Frog    62 HQALKEDILDFIKQAQARVLSHQDDTALLKAYIVEWRKF-FTQ------CDILPKPFCQLEITLM 119

  Fly   143 GQKGIYK--------IYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECY 199
            |::|..|        :.:|.|..|...:|..:...:..:.:|.:..||.|:..:..||..|.|.|
 Frog   120 GKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESY 184

  Fly   200 VELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQ 264
            |.|..|.||      ||.:|:.|||..::..|..||..::.::|..|.|..|:|:.:.:|:||..
 Frog   185 VNLCSNPED------KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEN 243

  Fly   265 RVRGFNSKNGLSYLHET-----TADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSL 324
            |        .|.|| ||     :...|...|...|:....:....|.|.::..:..:.|..|:||
 Frog   244 R--------ALRYL-ETRRECNSVQALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSL 299

  Fly   325 VALSSKNLTDLKSILENHILHQGTE---AIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFN 386
            :......:..:...||.||:..|..   |.|:..|||:    :.||:.:|.:..:::.||..||.
 Frog   300 MDKVPNGIEPMLKDLEEHIVSAGLADMVAAAETITTDS----EKYVEQLLTLFNRFSKLVKEAFQ 360

  Fly   387 NDNGFVAALDKACGKFINSNVVTI---------------ANSASKSPELLAKYCDLLLKKS--SK 434
            :|..|:.|.|||....:|.  .||               ....||.|||||.|||:||:|:  ||
 Frog   361 DDPRFLTARDKAYKAVVND--ATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSK 423

  Fly   435 NPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQT-CGYE 498
            ....:|:|..|.:|::|.||:::||||.:|:...|.:||:...||..:.|..|:..|::. ...:
 Frog   424 KLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPAD 488

  Fly   499 YTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEID-FGIEVLSSGSWPFQLSNNFL-LPSELER 561
            |..||.||||||.||:|||..||:......|.:..| ..|::|::|:|.......|: ||:|||.
 Frog   489 YVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELED 553

  Fly   562 SVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN----DQLS 622
            .:.:..|||...||||||:|.:.|..|.:..   :|....|.|:.:|||::||..:|    :::|
 Frog   554 LIPEVEEFYKKNHSGRKLHWHHLMSNGIITF---KNEVGQYDLEVTTFQLAVLFAWNQRPREKIS 615

  Fly   623 FTVQQLQDNTQTQQENLIQVLQIL-----LKAKVLTSSDNENSLTPESTVE-----------LFL 671
            |  :.|:..|:.....|.:.|..|     ||.:||:.....||  |:...|           |..
 Frog   616 F--ENLKLATELPDAELRRTLWSLVAFPKLKRQVLSYEPTVNS--PKDFTEGTLFSVNQEFSLIK 676

  Fly   672 DYKNKKR-RINI--NQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVL 733
            :.|.:|| :||:  ...|.||...|:|  ::.|.:.|.|..|.||::||||||::.:..|.:|::
 Frog   677 NGKVQKRGKINLIGRLQLTTERMREEE--NEGIVQLRILRTQEAIIQIMKMRKKITNAQLQTELV 739

  Fly   734 NQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ..|...|.|:..:||:.|:.|||.:|::|.|...:|:.|:|
 Frog   740 EILKNMFLPQKKMIKEQIEWLIEHKYIKRDESDINTFIYMA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	197/709 (28%)
		Cullin_Nedd8	704..765	CDD:463146	24/60 (40%)
cul5	NP_001072836.1	Cullin	19..672	CDD:459983	196/703 (28%)
		Cullin_Nedd8	711..772	CDD:463146	25/60 (42%)