DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul1

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001039255.1	Gene:	cul1 / 734121	XenbaseID:	XB-GENE-945766	Length:	776	Species:	Xenopus tropicalis

Alignment Length:	789	Identity:	493/789 - (62%)
Similarity:	598/789 - (75%)	Gaps:	32/789 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSV---------S 57
            |||.|.... |.:.||.||.:|..||.||:..: |:.:|:||..|||||:|||||         .
Frog     4 NRSQNPHGL-KQIGLDQIWDDLRAGIQQVYTRQ-SMAKSRYMELYTHVYNYCTSVHQSNQARGAG 66

  Fly    58 AAPSGRSSGKT-GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSS 121
            ..||....|:| ||||.||.:||.||::|||:||:.||...:.:..|.| |..||:||:.|:|||
Frog    67 VPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESV-LKFYTQQWEDYRFSS 130

  Fly   122 TVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKL 186
            .||:|||.||||:||:|||:||:||||:||.||||.|:..||:.||:.||.||||.||:||.|:.
Frog   131 KVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFKPLNKQVTNAVLKLIEKERNGET 195

  Fly   187 INRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEY 251
            ||..|:..|::.||||..||:|..|:...|:|||::||::|:|||..||.:||..||..|.||||
Frog   196 INTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEY 260

  Fly   252 LKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRND 316
            :|..|.||.||.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:|:
Frog   261 MKKAEARLLEEQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNE 317

  Fly   317 DLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALV 381
            ||.|||:||:.....|.:||.:||.||.:||..||.||... |.||||.||||:|||||||||||
Frog   318 DLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA-AQNDPKMYVQTVLDVHKKYNALV 381

  Fly   382 LTAFNNDNGFVAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNL 445
            ::|||||.|||||||||||:|||:|.|| :|.|:||||||||:|||.||||||||||:.||||.|
Frog   382 MSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTL 446

  Fly   446 NQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDI 510
            ||||||||||||||||||:|:||||||||:..||||||||.|||||||.||:|||.|||||||||
Frog   447 NQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDI 511

  Fly   511 GVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHS 575
            |||||||..||::|.... .:::||.|:||||||||||....|.||||||||.::|..|||:|||
Frog   512 GVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPFQQFCTFALPSELERSYQRFTAFYASRHS 575

  Fly   576 GRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLI 640
            ||||.||||:.||||:.|..:|.   ||||||||||::|||:|.:.::|||||.|:||.:.:.|:
Frog   576 GRKLTWLYQLSKGELVTNCFKNR---YTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILV 637

  Fly   641 QVLQILLKAKVLTSSD-NEN----SLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKH 700
            ||||||||:|:|...| |.|    .|.|:..::|:|.|||||.|:|||.|:|||.|.||||.||:
Frog   638 QVLQILLKSKLLVLEDENANVDDVDLKPDILIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702

  Fly   701 IEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEG 765
            |||||||||||||||||||||.|.|..|:.|||.|||:||||:|||||||||||||||||||::|
Frog   703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDG 767

  Fly   766 HKDTYSYLA 774
            .||||||||
Frog   768 EKDTYSYLA 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	400/663 (60%)
		CULLIN	454..593	CDD:214545	99/138 (72%)
		Cullin_Nedd8	701..765	CDD:214883	53/63 (84%)
cul1	NP_001039255.1	Cullin	21..662	CDD:366357	399/655 (61%)
cul1	NP_001039255.1	Cullin_Nedd8	703..770	CDD:214883	54/66 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	755	1.000	Domainoid score	I96
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2663
Inparanoid	1	1.050	927	1.000	Inparanoid score	I352
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	1	1.000	-	-		oto103880
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R262
SonicParanoid	1	1.000	-	-		X1841
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.010