Protein Alignment Cul1 and Cul4b

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_082564.3
• Gene: Cul4b / 72584
• MGIID: 1919834
• Length: 970
• Species: Mus musculus
• Alignment Length: 767
• Identity: 240/767 - (31%)
• Similarity: 384/767 - (50%)
• Gaps: 76/767 - (9%)

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCT-SVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |:.|.:|.|.: :..::..|: :......|..|.:.|: .:||                  .||.
Mouse   271 DETWQKLKEAV-EAIQNSTSI-KYNLEELYQAVENLCSHKISA------------------NLYK 315

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:.:|:..|.:.|| |.:..:.|:::.....::..|..:|:|.:|.:     .
Mouse   316 QLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ-----N 375

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  |.:.......:|..||.||.|:.|:|||:|.::....:
Mouse   376 SMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD------ 434

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.:|:.:||.:|:.:|:..|..|....:....|.|||.||..|||||..|:
Mouse   435 --------LQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRL------ 485

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||.:||...|.::.|:.|:.:|| .|......:||:.:|..||..:|.|.:.....:..|
Mouse   486 --ITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVL- 547

  Fly   337 SILENHILHQGTEAIAKCCTTDAAN--DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKAC 399
                   |.|..|.|....:|...|  ..||.||.:||...|.:.::.|.|..:..|:.|:.:|.
Mouse   548 -------LQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAF 605

  Fly   400 GKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKY 464
            ..|||..       .:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:
Mouse   606 ETFINKR-------PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 663

  Fly   465 YSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNL 529
            |.|.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:...||||:..:|:
Mouse   664 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNV 728

  Fly   530 TMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNV 594
            ...|:..:.:|:.|.||..:.....||.|:.:....|..||..:||||||.|  |...|..::..
Mouse   729 PGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQW--QSTLGHCVLKA 791

  Fly   595 NRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDN 657
            ....... .||.|.||..|||.||:...|::::::..|..:...|.:.||.|.  ||:||..:..
Mouse   792 EFKEGKK-ELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPK 855

  Fly   658 ENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKR 722
            ...:..........|:|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||||.
Mouse   856 GKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKT 920

  Fly   723 LNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |:|..|:|||.|||  :|..|...:||.|:.||:::|:||.:.:.:.|:|:|
Mouse   921 LSHNLLVSEVYNQL--KFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	192/661 (29%)
		Cullin_Nedd8	704..765	CDD:463146	33/60 (55%)
Cul4b	NP_082564.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..157
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q13620	112..115
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	189..211
		Cullin	274..871	CDD:459983	192/661 (29%)
		Cullin_Nedd8	902..962	CDD:463146	33/61 (54%)