DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and Cul4b

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_001103612.1	Gene:	Cul4b / 72584	MGIID:	1919834	Length:	970	Species:	Mus musculus

Alignment Length:	767	Identity:	240/767 - (31%)
Similarity:	384/767 - (50%)	Gaps:	76/767 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCT-SVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |:.|.:|.|.: :..::..|: :......|..|.:.|: .:||                  .||.
Mouse   271 DETWQKLKEAV-EAIQNSTSI-KYNLEELYQAVENLCSHKISA------------------NLYK 315

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:.:|:..|.:.|| |.:..:.|:::.....::..|..:|:|.:|.:     .
Mouse   316 QLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ-----N 375

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  |.:.......:|..||.||.|:.|:|||:|.::....:
Mouse   376 SMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD------ 434

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.:|:.:||.:|:.:|:..|..|....:....|.|||.||..|||||..|:
Mouse   435 --------LQIYQDSFEQQFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRL------ 485

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||.:||...|.::.|:.|:.:|| .|......:||:.:|..||..:|.|.:.....:..|
Mouse   486 --ITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLFSRVRGGVQVL- 547

  Fly   337 SILENHILHQGTEAIAKCCTTDAAN--DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKAC 399
                   |.|..|.|....:|...|  ..||.||.:||...|.:.::.|.|..:..|:.|:.:|.
Mouse   548 -------LQQWIEYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAF 605

  Fly   400 GKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKY 464
            ..|||..       .:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:
Mouse   606 ETFINKR-------PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAF 663

  Fly   465 YSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNL 529
            |.|.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:...||||:..:|:
Mouse   664 YKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNV 728

  Fly   530 TMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNV 594
            ...|:..:.:|:.|.||..:.....||.|:.:....|..||..:||||||.|  |...|..::..
Mouse   729 PGNIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQW--QSTLGHCVLKA 791

  Fly   595 NRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDN 657
            ....... .||.|.||..|||.||:...|::::::..|..:...|.:.||.|.  ||:||..:..
Mouse   792 EFKEGKK-ELQVSLFQTMVLLMFNEGEEFSLEEIKHATGIEDGELRRTLQSLACGKARVLAKNPK 855

  Fly   658 ENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKR 722
            ...:..........|:|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||||.
Mouse   856 GKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKT 920

  Fly   723 LNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |:|..|:|||.|||  :|..|...:||.|:.||:::|:||.:.:.:.|:|:|
Mouse   921 LSHNLLVSEVYNQL--KFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	191/656 (29%)
		CULLIN	454..593	CDD:214545	59/138 (43%)
		Cullin_Nedd8	701..765	CDD:214883	33/63 (52%)
Cul4b	NP_001103612.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..157
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q13620	112..115
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..211
		Cullin	275..870	CDD:279260	191/659 (29%)
		CULLIN	653..793	CDD:214545	59/141 (42%)
		Cullin_Nedd8	899..964	CDD:214883	33/66 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830