Protein Alignment Cul1 and Cul2

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_083678.2
• Gene: Cul2 / 71745
• MGIID: 1918995
• Length: 745
• Species: Mus musculus
• Alignment Length: 785
• Identity: 265/785 - (33%)
• Similarity: 438/785 - (55%)
• Gaps: 67/785 - (8%)

  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGK 76
            ::|:.|:.|::|:..|..|...| .:.|:.:...::.:|..|.   |.|           :.:|:
Mouse     6 RVVDFDETWNKLLTTIKAVVMLE-YVERATWNDRFSDIYALCV---AYP-----------EPLGE 55

  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKR--- 138
            :||...:.||:|::..|..  :.:..||.:|..|.:.|:.|...:..:|.:..|||..::|:
Mouse    56 RLYAETKIFLESHVRHLYK--RVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKL 118

  Fly   139 ---ECEEGQKGI------YKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRD 194
               :.:.|..|:      .:|..|||..|:..:.:.|...:.:.:|:.|:.:|.|:..|:.::..
Mouse   119 TEADIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHG 183

  Fly   195 VIECYVELSFNEEDTDAEQQK----LSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHV 255
            ||..:|.:         ||.|    |..|:..|.:.|:.:|..:|::|:...|..:..::|::.|
Mouse   184 VINSFVHV---------EQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKV 239

  Fly   256 ENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKR 320
            ..||::|..|.|        .|||.::...:...|::.::..||:..|:|..:::..:|.:|:..
Mouse   240 LGRLKDEEIRCR--------KYLHPSSYTKVIHECQQRMVADHLQFLHSECHSIIQQERKNDMAN 296

  Fly   321 MYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAAND--PKTYVQTILDVHKKYNALVLT 383
            ||.|:...|..|..:...|:.||..:|..|     |::...:  |..:|:::|:||.|:..|:.|
Mouse   297 MYVLLRAVSSGLPHMIEELQKHIHDEGLRA-----TSNLTQEHMPTLFVESVLEVHGKFVQLINT 356

  Fly   384 AFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQV 448
            ..|.|..|::|||||....:|...   ..|..|:|||||||||.|||||:|...:.|:||.|...
Mouse   357 VLNGDQHFMSALDKALTSVVNYRE---PKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSF 418

  Fly   449 MVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVS 513
            :.|||||:|||||||:|::||||||::..|.|.|:|..||:||||.||||:|.||.||:.|:.||
Mouse   419 ITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVS 483

  Fly   514 KDLNSYFKQYLAEKNLTME--IDFGIEVLSSGSWPFQL--SNNFLLPSELERSVRQFNEFYAARH 574
            .|||:.|..::..::..::  |.|.|.||.:|:||...  |:.|.:|.|||:||:.|..||:...
Mouse   484 ADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHF 548

  Fly   575 SGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENL 639
            |||||.||:.:|.||:.||.   ....|....:|:||:|||.||:..:.:.::|||:||..::.|
Mouse   549 SGRKLTWLHYLCTGEVKMNY---LGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKEL 610

  Fly   640 IQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704
            .:.::.||..|::.....:..:..||:..|.:.:.:|:.:..|...::.:...|.|.....::||
Mouse   611 TKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDED 675

  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769
            ||:.:|||||||||.||.|.|..||.||::|...||.|.:.:|||||::||:|:|:||.:...|.
Mouse   676 RKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADE 740

  Fly   770 YSYLA 774
            |||:|
Mouse   741 YSYVA 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	218/674 (32%)
		Cullin_Nedd8	704..765	CDD:463146	35/60 (58%)
Cul2	NP_083678.2	Cullin	14..644	CDD:459983	218/674 (32%)
		Cullin_Nedd8	675..735	CDD:463146	35/59 (59%)