DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul1 and Cul2

DIOPT Version :9

Sequence 1:NP_523655.1 Gene:Cul1 / 35742 FlyBaseID:FBgn0015509 Length:774 Species:Drosophila melanogaster
Sequence 2:NP_001347758.1 Gene:Cul2 / 71745 MGIID:1918995 Length:745 Species:Mus musculus


Alignment Length:785 Identity:265/785 - (33%)
Similarity:438/785 - (55%) Gaps:67/785 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGK 76
            ::|:.|:.|::|:..|..|...| .:.|:.:...::.:|..|.   |.|           :.:|:
Mouse     6 RVVDFDETWNKLLTTIKAVVMLE-YVERATWNDRFSDIYALCV---AYP-----------EPLGE 55

  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKR--- 138
            :||...:.||:|::..|..  :.:..||.:|..|.:.|:.|...:..:|.:..|||..::|:   
Mouse    56 RLYAETKIFLESHVRHLYK--RVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQYIKKNKL 118

  Fly   139 ---ECEEGQKGI------YKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRD 194
               :.:.|..|:      .:|..|||..|:..:.:.|...:.:.:|:.|:.:|.|:..|:.::..
Mouse   119 TEADIQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQNILIRMLLREIKNDRGGEDPNQKVIHG 183

  Fly   195 VIECYVELSFNEEDTDAEQQK----LSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHV 255
            ||..:|.:         ||.|    |..|:..|.:.|:.:|..:|::|:...|..:..::|::.|
Mouse   184 VINSFVHV---------EQYKKKFPLKFYQGIFVSPFLTETGEYYKQEASNLLQESNCSQYMEKV 239

  Fly   256 ENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKR 320
            ..||::|..|.|        .|||.::...:...|::.::..||:..|:|..:::..:|.:|:..
Mouse   240 LGRLKDEEIRCR--------KYLHPSSYTKVIHECQQRMVADHLQFLHSECHSIIQQERKNDMAN 296

  Fly   321 MYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAAND--PKTYVQTILDVHKKYNALVLT 383
            ||.|:...|..|..:...|:.||..:|..|     |::...:  |..:|:::|:||.|:..|:.|
Mouse   297 MYVLLRAVSSGLPHMIEELQKHIHDEGLRA-----TSNLTQEHMPTLFVESVLEVHGKFVQLINT 356

  Fly   384 AFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQV 448
            ..|.|..|::|||||....:|...   ..|..|:|||||||||.|||||:|...:.|:||.|...
Mouse   357 VLNGDQHFMSALDKALTSVVNYRE---PKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDKLTSF 418

  Fly   449 MVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVS 513
            :.|||||:|||||||:|::||||||::..|.|.|:|..||:||||.||||:|.||.||:.|:.||
Mouse   419 ITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVS 483

  Fly   514 KDLNSYFKQYLAEKNLTME--IDFGIEVLSSGSWPFQL--SNNFLLPSELERSVRQFNEFYAARH 574
            .|||:.|..::..::..::  |.|.|.||.:|:||...  |:.|.:|.|||:||:.|..||:...
Mouse   484 ADLNNKFNNFIRNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHF 548

  Fly   575 SGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENL 639
            |||||.||:.:|.||:.||.   ....|....:|:||:|||.||:..:.:.::|||:||..::.|
Mouse   549 SGRKLTWLHYLCTGEVKMNY---LGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKEL 610

  Fly   640 IQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704
            .:.::.||..|::.....:..:..||:..|.:.:.:|:.:..|...::.:...|.|.....::||
Mouse   611 TKTIKSLLDVKMINHDSEKEDIDAESSFSLNMSFSSKRTKFKITTSMQKDTPQELEQTRSAVDED 675

  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769
            ||:.:|||||||||.||.|.|..||.||::|...||.|.:.:|||||::||:|:|:||.:...|.
Mouse   676 RKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADE 740

  Fly   770 YSYLA 774
            |||:|
Mouse   741 YSYVA 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul1NP_523655.1 Cullin 21..669 CDD:279260 216/669 (32%)
CULLIN 454..593 CDD:214545 71/142 (50%)
Cullin_Nedd8 701..765 CDD:214883 36/63 (57%)
Cul2NP_001347758.1 Cullin 14..644 CDD:366357 218/674 (32%)
Cullin_Nedd8 677..735 CDD:371133 33/57 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5647
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.830

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