DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and Cul5

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_006243152.1	Gene:	Cul5 / 64624	RGDID:	621742	Length:	828	Species:	Rattus norvegicus

Alignment Length:	829	Identity:	235/829 - (28%)
Similarity:	391/829 - (47%)	Gaps:	135/829 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NSQTTQKLVN-----LDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSS 65
            |..|:..|.|     .:|.|..:...::::...| |:|:.|:...::.|:..|.......|
  Rat    75 NMATSNLLKNKGSLQFEDKWDFMRPIVLKLLRQE-SVTKQQWFDLFSDVHAVCLWDDKGSS---- 134

  Fly    66 GKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNY 130
                       |::..|::.:..::.:...:..:...:..||..|..:|:.: |:.      |:.
  Rat   135 -----------KIHQALKEDILEFIKQAQARVLSHQDDTALLKAYIVEWRKF-FTQ------CDI 181

  Fly   131 LNRNWVKRECE-EGQKGIYK--------IYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKL 186
            |.:.:.:.|.. .|::...|        :.:|.|..|...:|..:...:..:.:|.:..||.|:.
  Rat   182 LPKPFCQLEVTLLGKQSSNKKSNMEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEA 246

  Fly   187 INRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEY 251
            .:..||..|.|.||.|..|.||      ||.:|:.|||..::..|..||..::.::|..|.|..|
  Rat   247 FDSQLVIGVRESYVNLCSNPED------KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNY 305

  Fly   252 LKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRND 316
            :|                       ||.|...:.|.::.:|.::        .|.|.::..:..:
  Rat   306 MK-----------------------YLMECCVNALVTSFKETIL--------AECQGMIKRNETE 339

  Fly   317 DLKRMYSLVALSSKNLTDLKSILENHILHQGTE---AIAKCCTTDAANDPKTYVQTILDVHKKYN 378
            .|..|:||:......:..:...||.||:..|..   |.|:..|||:    :.||:.:|.:..:::
  Rat   340 KLHLMFSLMDKVPGGIEPMLKDLEEHIISAGLADMVAAAETITTDS----EKYVEQLLTLFNRFS 400

  Fly   379 ALVLTAFNNDNGFVAALDKACGKFINSNVVTI---------------ANSASKSPELLAKYCDLL 428
            .||..||.:|..|:.|.|||....:|.  .||               ....||.|||||.|||:|
  Rat   401 KLVKEAFQDDPRFLTARDKAYKAVVND--ATIFKLELPLKQKGVGLKTQPESKCPELLANYCDML 463

  Fly   429 LKKS--SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKL 491
            |:|:  ||....:|:|..|.:|::|.||:::||||.:|:...|.:||:...||..:.|..|:..|
  Rat   464 LRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWL 528

  Fly   492 KQT-CGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEID-FGIEVLSSGSWPFQLSNNFL 554
            ::. ...:|..||.||||||.||:|||..||:......|.:..| ..|::|::|:|.......|:
  Rat   529 REVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFV 593

  Fly   555 -LPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN 618
             ||:|||..:.:..|||...||||||:|.:.|..|.:..   :|....|.|:.:|||::||..:|
  Rat   594 SLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITF---KNEVGQYDLEVTTFQLAVLFAWN 655

  Fly   619 ----DQLSFTVQQLQDNTQTQQENLIQVLQIL-----LKAKVLTSSDNENSLTPESTVE--LF-- 670
                :::||  :.|:..|:.....|.:.|..|     ||.:||......||  |:...|  ||
  Rat   656 QRPREKISF--ENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYDPQVNS--PKDFTEGTLFSV 716

  Fly   671 -LDY---KN----KKRRINI--NQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNH 725
             .|:   ||    |:.:||:  ...|.||...|:|  ::.|.:.|.|..|.||::||||||::::
  Rat   717 NQDFSLIKNAKVQKRGKINLIGRLQLTTERMREEE--NEGIVQLRILRTQEAIIQIMKMRKKISN 779

  Fly   726 TNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ..|.:|::..|...|.|:..:||:.|:.|||.:|:.|.|...:|:.|:|
  Rat   780 AQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDEADINTFIYMA 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	187/690 (27%)
		CULLIN	454..593	CDD:214545	54/141 (38%)
		Cullin_Nedd8	701..765	CDD:214883	25/63 (40%)
Cul5	XP_006243152.1	Cullin	95..719	CDD:279260	189/696 (27%)
		CULLIN	491..634	CDD:214545	54/145 (37%)
		Cullin_Nedd8	761..820	CDD:287520	24/58 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820