Protein Alignment Cul1 and cul4a

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001015893.1
• Gene: cul4a / 548647
• XenbaseID: XB-GENE-1014775
• Length: 753
• Species: Xenopus tropicalis
• Alignment Length: 765
• Identity: 234/765 - (30%)
• Similarity: 370/765 - (48%)
• Gaps: 74/765 - (9%)

  Fly    18 DIWSELVEGIMQVFEHEKSLTRSQY--MRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |.|.:|.|.:..:    :|.|..:|  ...|..|.:.|                 :..|...||.
 Frog    55 DTWQKLQEAVNAI----ESSTSIKYNLEELYQAVENLC-----------------SYKVSHTLYK 98

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:.:|:..|.:..| |.:..:.||.:.....::..|..:|:|.:|.:     .
 Frog    99 QLRQVCEEHMKAQIHQFREDSLDSFLFLKKVNRCWKDHCRQMIMIRSIFLFLDRTYVLQ-----N 158

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  :::.......:||.||:||.|:.::|||:|.::....:
 Frog   159 SMLPSIWDMGLELFRCHVVSDRMVQIKTIDGILKLIEQERSGEAVDRSLLRSLLGMLSD------ 217

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.|||::||.||:.:|:..|..|....:....|.|||.||..|||||..||
 Frog   218 --------LQVYKESFETKFLEETNCLYAAEGQRLMQEREVPEYLHHVNRRLEEEVDRV------ 268

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||...|...|.:..|:.|:.:|| .|.....:|:|:.:|:.:|..||.|.:........|.
 Frog   269 --ITYLDHGTHKPLIACVEKQLLGEHLTAILQKGLKNMLDENRDPELTLMYQLFSRVKGGQIILL 331

  Fly   337 SILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGK 401
            .....:|.:.|:..:..      ....|..||.:||.....:.::...|..:..||..:.::...
 Frog   332 QHWGEYIKNFGSGLVIN------PEKDKDMVQELLDFKDNVDHIIDVCFQKNEKFVNTMKESFET 390

  Fly   402 FINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYS 466
            |||       ..|:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:|.
 Frog   391 FIN-------RRANKPAELIAKYVDSKLRSGNKEATDEELERLLDKIMIIFRFIHGKDVFEAFYK 448

  Fly   467 KMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTM 531
            |.|||||:...|||.|:|..|:||||..||..:|.||:.||:|:.:|||:...|||::...:...
 Frog   449 KDLAKRLLVGKSASVDSEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDVMVQFKQHMQNHSDPG 513

  Fly   532 EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNR 596
            .||..:.:|:.|.||.....:..||:|:.:....|..||..:||||:|.|  |...|..::..:.
 Frog   514 NIDLTVNILTMGYWPTYTPVDVHLPAEMVKLQEIFKAFYLGKHSGRRLQW--QSTLGHAVLKADF 576

  Fly   597 NNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDNEN 659
            ..... .||.|.||..|||.||....|..::::..|..:...|.:.||.|.  ||:||..|....
 Frog   577 KEEKK-ELQVSLFQTLVLLLFNKGDEFGFEEIKITTGIEDNELRRTLQSLACGKARVLNKSPKSK 640

  Fly   660 SLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLN 724
            .:..........|:|:|..||.|||....|...||....:.:.:||:..|.|||||||||||.|.
 Frog   641 DVEDGDRFCFNADFKHKLYRIKINQIQMKETVEEQVNTTERVFQDRQYQIDAAIVRIMKMRKTLT 705

  Fly   725 HTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |..|:||:.|||  :|..|...:||.|:.||:::|:||.:.:...|.|||
 Frog   706 HNLLVSELYNQL--KFPVKPGDLKKRIESLIDRDYMERDKDNAKQYHYLA 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	185/655 (28%)
		CULLIN	454..593	CDD:214545	56/138 (41%)
		Cullin_Nedd8	701..765	CDD:214883	32/63 (51%)
cul4a	NP_001015893.1	Cullin	58..653	CDD:279260	185/658 (28%)
		CULLIN	436..576	CDD:214545	56/141 (40%)
		Cullin_Nedd8	682..747	CDD:214883	32/66 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010