Protein Alignment Cul1 and Cul5

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_651665.2
• Gene: Cul5 / 43434
• FlyBaseID: FBgn0039632
• Length: 852
• Species: Drosophila melanogaster
• Alignment Length: 900
• Identity: 234/900 - (26%)
• Similarity: 397/900 - (44%)
• Gaps: 203/900 - (22%)

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDR 81
            :::|.:....::::...: ::::.::...:..|:..|.          ..:.|.|     |:||.
  Fly    14 EEVWPDKRRIVLKLLRQD-TVSQREWQDLFFGVHFVCL----------WDEKGAA-----KIYDC 62

  Fly    82 LEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEE---- 142
            |:|.:..::.:..::.:|..||:.||:.|..:|:.:...|       |||...:  |:.|:
  Fly    63 LQQDIVEFIVQAQSQVQAQRGEQALLATYIVEWRKFFTQS-------NYLPLPF--RQLEQSPQV 118

  Fly   143 --------------------------------GQKG----------------------------- 146
                                            ||.|
  Fly   119 KPSSSGSSSSASVSASGASTSAAAAAAATSCSGQAGKSGASTSAAAGASTSAAAAAASTSASTSS 183

  Fly   147 --------------------------IYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGK 185
                                      ...:.:|.|.:|..|:|..:...:.::.:|.:..||.|.
  Fly   184 AAAAAAASGSGSSSSSTSTSKKNPTEDSPVRKLMLDSWNKHIFHDIKHRLQESAMKIVHAERNGD 248

  Fly   186 LINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTE 250
            ..:..||..|.|.||.||.|.||      ||.:|::|||..::..|..||..:|......|.|..
  Fly   249 AYDAQLVVGVRESYVNLSSNAED------KLEIYRENFEMAYLKATVEFYRLKSAEQQQENGVLA 307

  Fly   251 YLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRN 315
            |:|:.:::|.||..|.:        .||..::..:|..|...|||..||.....|...|:.....
  Fly   308 YMKYADSKLREEEVRAK--------RYLEPSSFSILTYTLVNVLIVDHLNSIIAECPALIRDYET 364

  Fly   316 DDLKRMYSLV--ALSSKNLTDLKSILENHILHQG-------TEAIAKCCTTDAANDPKTYVQTIL 371
            :.|..|:.|:  .:....:..:...|:.||:..|       :|.|.:        |.:.||:.:|
  Fly   365 ERLNLMFRLMDRVMHGVGVEPMMGDLQRHIMSAGLADMLSASEVITQ--------DSEKYVERLL 421

  Fly   372 DVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVV-------TIANSA-------SKSPELLA 422
            ::..|::.||..|||:|..|:.|.|.|....:|...|       :|||..       ||.|||||
  Fly   422 ELFNKFSDLVRNAFNDDPRFLTARDIAFKTVVNDTSVFKMELPTSIANRGVKYTAPESKCPELLA 486

  Fly   423 KYCDLLLKKS--SKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEA 485
            .|||:||:::  ||....::::..|..|::|.||:.:||||.:|:...|.:||:..|||..:.|.
  Fly   487 NYCDMLLRRTPLSKRLTSEQIDARLRDVLLVLKYVNNKDVFMRYHKVHLTRRLILGTSADSEKEE 551

  Fly   486 MMISKLKQT-CGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQL 549
            .::..|::. ...:|..:|.||||||.||:|||:.|:..::..:.     ..|::|::|:|. :.
  Fly   552 DIVEWLREVGMPADYVNRLARMFQDIKVSEDLNTQFRTSISRHDA-----INIKILNAGAWA-RC 610

  Fly   550 SN--NFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMS 612
            |.  :..||.|||..:....|||..:||||||.|.:.|..|.:..   .||...|.|..:||||:
  Fly   611 SERVSVSLPIELEDYIPDVEEFYKKKHSGRKLQWYHHMSNGTITF---VNNFGRYDLDVTTFQMA 672

  Fly   613 VLLQFN----DQLSFTVQQLQDNTQTQQENLIQVL-----------QILLKAKVLTSSDNENSLT 662
            ||..:|    |::|:  :.|:..|:.....|.:.|           ||||......||..:.:
  Fly   673 VLFAWNQRQHDKISY--ENLRLATELPDPELRRTLWSLVAFPKIKKQILLMEPAAISSPKDFA-- 733

  Fly   663 PESTV----ELFLDYKNKK--RRININQPLKTELKVE--QETVHKHIEEDRKLLIQAAIVRIMKM 719
             |:|:    :.|...||.|  ||..:|...:.:|..|  |:..::.|.:.|.|..|.||::|||:
  Fly   734 -ENTMFYINQEFAIVKNGKSQRRGKLNLIGRLQLSTERSQQEDNQSIVQLRILRTQEAIIKIMKV 797

  Fly   720 RKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |||:|:..|..|:::.|...|.|...:||:.::.|||.:|:.|.:...:.:.|:|
  Fly   798 RKRMNNAALQGELIDILKNMFLPSKKMIKEQLEWLIENKYMRRDDDDINMFIYVA 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	196/785 (25%)
		CULLIN	454..593	CDD:214545	50/141 (35%)
		Cullin_Nedd8	701..765	CDD:214883	25/63 (40%)
Cul5	NP_651665.2	Cullin	33..743	CDD:279260	196/769 (25%)
		CULLIN	520..655	CDD:214545	50/140 (36%)
		Cullin_Nedd8	779..846	CDD:214883	25/66 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467938
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850