Protein Alignment Cul1 and cul1b

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_998660.1
• Gene: cul1b / 406816
• ZFINID: ZDB-GENE-040426-2887
• Length: 774
• Species: Danio rerio
• Alignment Length: 787
• Identity: 493/787 - (62%)
• Similarity: 596/787 - (75%)
• Gaps: 31/787 - (3%)

  Fly     4 SGNSQTTQ--KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAA-----PS 61
            |...|.|.  |.:.|:.||.:|..||.||:..: |:.||:||..|||||:|||||..|     ||
Zfish     3 STRGQNTHGLKQIGLEQIWDDLRSGIQQVYTRQ-SMARSRYMELYTHVYNYCTSVHQARPTGIPS 66

  Fly    62 GRSSGKT---GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTV 123
            .:.|.||   ||||.||.:||.||:.||:|||:.||...:.:..|.| |..||:||:.|:|||.|
Zfish    67 SKPSKKTPTPGGAQFVGLELYKRLKDFLRSYLTNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKV 130

  Fly   124 LDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLIN 188
            |||||.||||:||:|||:||:||||:||.|||..|:..||:.||:.||.||||.:|:||.|:.||
Zfish   131 LDGICAYLNRHWVRRECDEGRKGIYEIYSLALATWRECLFRPLNKQVTNAVLKLVEKERNGETIN 195

  Fly   189 RSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLK 253
            ..||..|::.||||..||:|...:...|||||:.||.:|:|||..||.:||..||..|.||||:|
Zfish   196 TRLVSGVVQSYVELGLNEDDAFVKGPTLSVYKEYFEAQFLADTERFYTRESTEFLQQNPVTEYMK 260

  Fly   254 HVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDL 318
            ..|.||.||.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:|:||
Zfish   261 KAEARLLEEQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDL 317

  Fly   319 KRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLT 383
            .|||:||:..:..|.:||.:||:||.:||..||.| |...|.||||.||||.|||||||||||::
Zfish   318 GRMYNLVSRITDGLGELKKLLESHIHNQGLAAIEK-CGDSALNDPKMYVQTTLDVHKKYNALVMS 381

  Fly   384 AFNNDNGFVAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQ 447
            |||||.|||||||||||:|||:|.|| :|.|:||||||||:|||.||||||||||:.||||.|||
Zfish   382 AFNNDAGFVAALDKACGRFINNNAVTRMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQ 446

  Fly   448 VMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGV 512
            ||||||||||||||||:|:||||||||:..||||||||.|||||||.||:|||.|||||||||||
Zfish   447 VMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGV 511

  Fly   513 SKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGR 577
            |||||..||::|:... .:::||.|:||||||||||.|..|.||||||||.::|..||.:|||||
Zfish   512 SKDLNEQFKKHLSNSE-PLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYGSRHSGR 575

  Fly   578 KLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQV 642
            ||.|||.:.||||:.|..:|.   ||||||||||::|||||.:..::||||.|:||.:.:.|:||
Zfish   576 KLTWLYHLSKGELVTNCFKNR---YTLQASTFQMAILLQFNTENCYSVQQLADSTQIKTDILVQV 637

  Fly   643 LQILLKAKVLTSSD-----NENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIE 702
            ||||||:|:|...|     :|....|::.::|||.|||||.|:|||.|:|||.|.||||.||:||
Zfish   638 LQILLKSKLLVLEDENANIDEMDFKPDTLIKLFLGYKNKKLRVNINVPMKTEQKQEQETTHKNIE 702

  Fly   703 EDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHK 767
            |||||||||||||||||||.|.|..|::|||||||:||||:|||||||||||||||||||::|.|
Zfish   703 EDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEK 767

  Fly   768 DTYSYLA 774
            |||||||
Zfish   768 DTYSYLA 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	404/666 (61%)
		Cullin_Nedd8	704..765	CDD:463146	51/60 (85%)
cul1b	NP_998660.1	Cullin	21..660	CDD:459983	400/653 (61%)
		Cullin_Nedd8	704..766	CDD:463146	51/61 (84%)