DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and AT1G43140

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_175007.2	Gene:	AT1G43140 / 3767291	AraportID:	AT1G43140	Length:	721	Species:	Arabidopsis thaliana

Alignment Length:	785	Identity:	216/785 - (27%)
Similarity:	380/785 - (48%)	Gaps:	96/785 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QKLVNLDDIWSELVEGI---MQVFE--HEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGG 70
            ::|:.|::.||.:..|:   .::.|  .|......||:..||.:||.|  :...|:..|
plant    12 KELILLEEGWSVMKTGVAKLQRILEDLSEPPFDPGQYINLYTIIYDMC--LQQPPNDYS------ 68

  Fly    71 AQLVGKKLYDRLEQFLKSYLSE-LLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRN 134
                 ::||::....:..|..| :|...:...| |.:|....|:|.:::.....|...|.||:|.
plant    69 -----QELYNKYRGVVDHYNKETVLPSMRERHG-EYMLRELVKRWANHKILVRWLSRFCFYLDRF 127

  Fly   135 WVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECY 199
            :|.|      :|:..:..:...::...::|.:.......:|..|.:||:|:.|:|:||::||:.|
plant   128 YVAR------RGLPTLNDVGFTSFHDLVYQEIQSEAKDVLLALIHKEREGEQIDRTLVKNVIDVY 186

  Fly   200 VELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQ 264
            ......:         :.:|:::||:..:.||:::|.:::..:...::..:|:...|..|:.|.:
plant   187 CGNGVGQ---------MVIYEEDFESFLLQDTASYYSRKASRWSQEDSCPDYMLKAEECLKLEKE 242

  Fly   265 RVRGFNSKNGLSYLHETTADVLKSTCEE---VLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLV 325
            ||        .:|||.||...|....:.   |::.|.| :..|:....||..|:..||.|||.|.
plant   243 RV--------TNYLHSTTEPKLVEKVQNELLVVVAKQLIENEHSGCLALLRDDKMGDLSRMYRLY 299

  Fly   326 ALSSKNLTDLKSILENHILHQGTEAI---AKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNN 387
            .|..:.|..:..:.:.|:..:|...|   |...|...|:..:..|:..:::|.||...|...|..
plant   300 RLIPQGLEPIADLFKQHVTAEGNALIKQAADAATNQDASASQVLVRKEIELHDKYMVYVDECFQK 364

  Fly   388 DNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKK--SSKNPEDKELEDNLNQVMV 450
            .:.|...|.:|...|.|..|     :.:.|.|:||.|||.:||.  .|:...|:..|..|.:|:.
plant   365 HSLFHKLLKEAFEVFCNKTV-----AGASSAEILATYCDNILKTRGGSEKLSDEATEITLEKVVN 424

  Fly   451 VFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKD 515
            :..||.|||:|.::|.|..|:||:...|.                       :.:...||.::::
plant   425 LLVYISDKDLFAEFYRKKQARRLLFDRSG-----------------------IMKEVTDITLARE 466

  Fly   516 LNSYFKQYLAEKNLT--MEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRK 578
            |.:.|..||: .|:|  :.|||.:.||::|.||...:.:..||:|:...|..|..||..:.:.|:
plant   467 LQTNFVDYLS-ANMTTKLGIDFTVTVLTTGFWPSYKTTDLNLPTEMVNCVEAFKVFYGTKTNSRR 530

  Fly   579 LNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN--DQLSFTVQQLQDNTQTQQENLIQ 641
            |:|:|.:....::   .:....|..|..||:|.:|||.||  ::||:|  ::.:......|:|::
plant   531 LSWIYSLGTCHIL---GKFEKKTMELVVSTYQAAVLLLFNNAERLSYT--EISEQLNLSHEDLVR 590

  Fly   642 VLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEED 704
            :|..|  ||.|:|.......:::...|.|....:.:|.|:|.:..|...|.|    .|.:.:::|
plant   591 LLHSLSCLKYKILIKEPMSRTISKTDTFEFNSKFTDKMRKIRVPLPPMDERK----KVVEDVDKD 651

  Fly   705 RKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDT 769
            |:..|.||:|||||.||.|.|..|:||.:..||..|||.:.:|||.|:.||.::||||...:.:|
plant   652 RRYAIDAALVRIMKSRKVLAHQQLVSECVEHLSKMFKPDIKMIKKRIEDLINRDYLERDTENANT 716

  Fly   770 YSYLA 774
            :.|:|
plant   717 FKYVA 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	170/668 (25%)
		CULLIN	454..593	CDD:214545	39/140 (28%)
		Cullin_Nedd8	701..765	CDD:214883	32/63 (51%)
AT1G43140	NP_175007.2	Cullin	48..623	CDD:279260	166/645 (26%)
		CULLIN	428..546	CDD:214545	39/144 (27%)
		Cullin_Nedd8	653..713	CDD:287520	30/59 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101330
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730