Protein Alignment Cul1 and Cul3

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_723909.2
• Gene: Cul3 / 34896
• FlyBaseID: FBgn0261268
• Length: 934
• Species: Drosophila melanogaster
• Alignment Length: 821
• Identity: 237/821 - (28%)
• Similarity: 403/821 - (49%)
• Gaps: 113/821 - (13%)

  Fly     3 RSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGK 67
            |:.|:...:|.|  :.||:.|...|.::  .:|:.:...:.:.|.:.|:......
  Fly   178 RAFNASMDEKYV--ETIWASLKNAIQEI--QKKNNSGLSFEQLYRNAYNMVLHKH---------- 228

  Fly    68 TGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLD 125
                   |.:||..|.:.:..:|..   |.:|    :||       |.:..:.|..:|.|..::.
  Fly   229 -------GNRLYYGLREVVSEHLEH---KVRA----DVLEALHSNFLPKLNQAWTDHQTSMVMIR 279

  Fly   126 GICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLIN 188
            .|..|::|.:|:      |:.:..:|.|.|:.::..:  :..:.:.:.:.:|..:.|||.|:.||
  Fly   280 DILMYMDRVYVQ------QREVDNVYNLGLILFRDQVVRYSEIQKALREKLLGMVMEERHGEAIN 338

  Fly   189 RSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLK 253
            ...:::.....:.|..|..         :||:::||..|:|.::|||:.||..||:.|....|:|
  Fly   339 HLAIKNACSMLITLGINSR---------TVYEEDFEKPFLAQSAAFYKFESQNFLAENNAGVYIK 394

  Fly   254 HVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNAD 313
            .||.|:.||:.|        ...||.:.|...:....||.||:||::.. .|.:|     ::...
  Fly   395 KVEARITEESSR--------AALYLDKDTEPRIVRVVEEELIKKHMRPI-VEMENSGVVYMIKNS 450

  Fly   314 RNDDLKRMYSLVA-LSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKY 377
            :.:||...|.|.: |..:.|..:...:..::..||...:.:  ..:...:|.|:||.:||:..::
  Fly   451 KTEDLACTYKLFSRLKEEGLKVIADTMSAYLREQGRMLVKE--EENGNTNPITFVQNLLDLKDRF 513

  Fly   378 NALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELE 442
            :..::.:|.||..|...:......|:|.|        :||||.|:.:.|..|||..|...::|:|
  Fly   514 DQFLVHSFANDRIFKNVISSDFEHFLNLN--------NKSPEYLSLFIDDKLKKGGKGMSEQEIE 570

  Fly   443 DNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMF 507
            ..|::.||:|:::.:||||::||...|||||:.:.|.|||.|..||||||..||.::|.||:.||
  Fly   571 SILDKTMVLFRFLLEKDVFERYYKTHLAKRLLLNKSVSDDFEKNMISKLKTECGCQFTSKLEGMF 635

  Fly   508 QDIGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFY 570
            :|:.||..:...||.::...||:: .::..:.:|::|.||.|.:. |..:|:....:...|..||
  Fly   636 KDMSVSNTIMDEFKNFVNNNNLSLGGVELTVRILTTGFWPTQTATPNCNIPAAPREAFDIFKNFY 700

  Fly   571 AARHSGRKLNWLYQMCKGELIMNV--------------NRNNSST-----------YTLQASTFQ 610
            ..:||||:|....||  |...:|.              :..:||:           :.||.||:|
  Fly   701 LNKHSGRQLTLQPQM--GTAYINAVFYGRKAVESEKDKDAPSSSSSGCGVPTTTRKHILQVSTYQ 763

  Fly   611 MSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFL 671
            |.|||.||::...|...:...|...:..|::.||.|...|    :|..:....:...|.|.|.::
  Fly   764 MCVLLLFNNRDVLTYDDIHQETDIPERELVRALQSLSMGKPAQRLLVRNSKTKTKDIEPTDEFYV 828

  Fly   672 D--YKNKKRRININQ-PLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVL 733
            :  :.:|..|:.|.. ..|.|.:.|::.....::||||..|:||||||||.||||.|..|:|:|.
  Fly   829 NDAFNSKFHRVKIQTVAAKGESEPERKETRGKVDEDRKHEIEAAIVRIMKARKRLAHNLLVSDVT 893

  Fly   734 NQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            :||.:||.|....|||.|:.|||:|||:|....:..|:|||
  Fly   894 SQLKSRFLPSPVFIKKRIEGLIEREYLQRSPEDRKVYNYLA 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	185/700 (26%)
		Cullin_Nedd8	704..765	CDD:463146	36/60 (60%)
Cul3	NP_723909.2	Cullin	193..832	CDD:459983	185/700 (26%)
		Cullin_Nedd8	864..926	CDD:463146	36/61 (59%)