Protein Alignment Cul1 and cul5a

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001314988.1
• Gene: cul5a / 327215
• ZFINID: ZDB-GENE-030131-5426
• Length: 780
• Species: Danio rerio
• Alignment Length: 821
• Identity: 233/821 - (28%)
• Similarity: 393/821 - (47%)
• Gaps: 113/821 - (13%)

  Fly    14 VNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            :..:|.| :|:..|:.....::|:|:.|:...::.|:..|......|:               |:
Zfish    13 LQFEDKW-DLMRPIVLKLLRQESVTKQQWFDQFSDVHAVCLWDDKGPA---------------KI 61

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECE-E 142
            :..|::.:..::.:...:..:...:..||..|..:|:.: |:.      |:.|.:.:.:.|.. .
Zfish    62 HQALKEDILDFIKQAQARVLSHQDDTALLKAYIVEWRKF-FTQ------CDILPKPFCQLEITLM 119

  Fly   143 GQKGIYK--------IYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECY 199
            |::|..|        :.:|.|..|...:|..:...:..:.:|.:..||.|:..:..||..|.|.|
Zfish   120 GKQGSSKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESY 184

  Fly   200 VELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQ 264
            |.|..|.||      ||.:|:.|||..::..|..||..::.::|..|.|..|:|:.:.:|.||
Zfish   185 VNLCSNPED------KLQIYRDNFEKSYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLREE-- 241

  Fly   265 RVRGFNSKNGLSYLHET-----TADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSL 324
                  .|..|.|| ||     :...|...|...|:....:....|...::..:..|.|..|:||
Zfish   242 ------EKRALRYL-ETRRECNSVQALMECCVNALVTSFKETILAECPGMIKRNETDKLHLMFSL 299

  Fly   325 VALSSKNLTDLKSILENHILHQGTE---AIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFN 386
            :......:..:...||.||:..|..   |.|:..|||:    :.||:.:|.:..:::.||..||.
Zfish   300 MDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDS----EKYVEQLLTLFNRFSKLVKEAFQ 360

  Fly   387 NDNGFVAALDKACGKFINSNVVTI---------------ANSASKSPELLAKYCDLLLKKS--SK 434
            :|..|:.|.|||....:|.  .||               ....||.|||||.|||:||:|:  ||
Zfish   361 DDPRFLTARDKAYKAVVND--ATIFKLELPMKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSK 423

  Fly   435 NPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQT-CGYE 498
            ....:::|..|.:|::|.||:::||||.:|:...|.:||:...||..:.|..|:..|::. ...:
Zfish   424 KLTSEDIELKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLREVGMPAD 488

  Fly   499 YTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEID-FGIEVLSSGSWPFQLSNNFL-LPSELER 561
            |..||.||||||.||:|||..||:......|.:..| ..|::|::|:|.......|: ||:|||.
Zfish   489 YVNKLARMFQDIKVSEDLNQVFKEMHKHNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTELED 553

  Fly   562 SVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFN----DQLS 622
            .:.:..:||...||||||:|.:.|..|.:..   :|....|.|:.:|||::||..:|    :::|
Zfish   554 LIPEVEDFYKKNHSGRKLHWHHLMSNGIITF---KNEVGQYDLEVTTFQLAVLFAWNQRPREKIS 615

  Fly   623 FTVQQLQDNTQTQQENLIQVLQIL-----LKAKVLTSSDNENSLTPESTVELFLDYKN------- 675
            |  :.|:..|:.....|.:.|..|     ||.:||......:|  |:...:..|.:.|
Zfish   616 F--ENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVSS--PKDFTDSTLFFVNQEFSLIK 676

  Fly   676 -----KKRRINI--NQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVL 733
                 |:.:||:  ...|.||...|:|  ::.|.:.|.|..|.||::||||||::.:..|.:|::
Zfish   677 NSKAQKRGKINLIGRLQLTTERMREEE--NEGIVQLRILRTQEAIIQIMKMRKKITNAQLQTELV 739

  Fly   734 NQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ..|...|.|:..:||:.|:.|||.:|::|.|...:|:.|:|
Zfish   740 EILKNMFLPQKKMIKEQIEWLIEHKYIKRDETDINTFIYMA 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	194/698 (28%)
		Cullin_Nedd8	704..765	CDD:463146	24/60 (40%)
cul5a	NP_001314988.1	Cullin	19..672	CDD:459983	195/703 (28%)
		Cullin_Nedd8	711..772	CDD:463146	25/60 (42%)