DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul3a

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_955985.2	Gene:	cul3a / 324655	ZFINID:	ZDB-GENE-030131-3376	Length:	774	Species:	Danio rerio

Alignment Length:	812	Identity:	228/812 - (28%)
Similarity:	394/812 - (48%)	Gaps:	118/812 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 QKLVNLDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHVYDYCTSVSAAPSGRSSGKT 68
            :|.||  :||..|...|.::.....|      |.|:.| |..:.|
Zfish    33 EKYVN--NIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKH-------------------- 75

  Fly    69 GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLDG 126
                  |:|||..|.:.:..:   |:.|.:    |:||       |....:.|..:|.:..::..
Zfish    76 ------GEKLYTGLREVVTEH---LINKVR----EDVLHSLNNNFLQTLNQAWNDHQTAMVMIRD 127

  Fly   127 ICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLINR 189
            |..|::|.:|:      |..:..:|.|.|:.::..:  :..:.:.:.:.:|..|..||:|::::|
Zfish   128 ILMYMDRVYVQ------QNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERRGEVVDR 186

  Fly   190 SLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKH 254
            ..:|:..:..:.|..         :..|||:::||..|:..::.|::.||..||:.|:.:.|:|.
Zfish   187 GAIRNACQMLMVLGL---------EGRSVYEEDFEIPFLDMSAEFFQMESQKFLAENSASVYIKK 242

  Fly   255 VENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNADR 314
            ||.|:.||.:||        :..|.::|.:.:....|..||.||:|.. .|.:|     :|...:
Zfish   243 VEARINEEIERV--------MHCLDKSTEEPIVKVVERELISKHMKTI-VEMENSGLVHMLKNGK 298

  Fly   315 NDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNA 379
            .:||..||.|.......|..:...:..::..||...:::   .....:|..|:|.:||:..:::.
Zfish   299 TEDLACMYKLFGRVPNGLKTMCECMSWYLREQGKALVSE---EGEGKNPVDYIQGLLDLKSRFDR 360

  Fly   380 LVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDN 444
            .:..:||||..|...:......|:|.|        |:|||.|:.:.|..|||..|...::|:|..
Zfish   361 FLQESFNNDRLFKQTIAGDFEYFLNLN--------SRSPEYLSLFIDDKLKKGVKGLTEQEVESI 417

  Fly   445 LNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQD 509
            |::.||:|:::::||||::||.:.||:||:.:.|.|||:|..||||||..||.::|.||:.||:|
Zfish   418 LDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRD 482

  Fly   510 IGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFYAA 572
            :.:|......|:.:|....::: .:|..:.||::|.||.|.:. ...:|.....:...|..||.|
Zfish   483 MSISNTTMDEFRHHLQTSQVSLCGVDLTVRVLTTGYWPTQSATPKCNIPPSPRHAFEVFRRFYLA 547

  Fly   573 RHSGRKLNWLYQMCKGELIMN-------------------VNRNNSSTYTLQASTFQMSVLLQFN 618
            :||||:|...:.|...:|...                   :..:|:..:.||.|||||::|:.||
Zfish   548 KHSGRQLTLQHHMGSADLNATFYGPIKKEDGSDVGVGGALLTGSNTRKHILQVSTFQMTILMLFN 612

  Fly   619 DQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFLDYKNKKRR 679
            ::..||.:::|..|...:..|::.||.|...|    |||.......:.......:...:.:|..|
Zfish   613 NREKFTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHVFTVNDQFTSKLHR 677

  Fly   680 ININ--QPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
            :.|.  ...:.|...|::...:.:::|||..|:||||||||.||::.|..|::||..||..||.|
Zfish   678 VKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLRARFLP 742

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...||||.|:.|||:|||.|....:..|:|:|
Zfish   743 SPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	180/693 (26%)
		CULLIN	454..593	CDD:214545	51/140 (36%)
		Cullin_Nedd8	701..765	CDD:214883	35/63 (56%)
cul3a	NP_955985.2	Cullin	41..670	CDD:279260	180/696 (26%)
		CULLIN	427..569	CDD:214545	51/141 (36%)
		Cullin_Nedd8	706..766	CDD:287520	33/59 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830