DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul1a

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_955953.2	Gene:	cul1a / 323883	ZFINID:	ZDB-GENE-030131-2603	Length:	777	Species:	Danio rerio

Alignment Length:	791	Identity:	495/791 - (62%)
Similarity:	599/791 - (75%)	Gaps:	36/791 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGNSQTTQ--KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSV---------S 57
            |..:||..  |.:.||.||.:|..||.||:..: |:.:|:||..|||||:|||||         .
Zfish     3 SNRTQTPHGLKQIGLDQIWDDLRAGIQQVYTRQ-SMAKSRYMELYTHVYNYCTSVHQSNQVRGGG 66

  Fly    58 AAPSGRSSGKT---GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQF 119
            .||| :.|.||   ||||.||.:||.||::|||:||:.||...:.:..|.| |..||:||:.|:|
Zfish    67 PAPS-KPSKKTPTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESV-LKFYTQQWEDYRF 129

  Fly   120 SSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQG 184
            ||.||:|||.||||:||:|||:||:||||:||.||||.|:..||:.||:.||.||||.||:||.|
Zfish   130 SSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRECLFRPLNKQVTNAVLKLIEKERNG 194

  Fly   185 KLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVT 249
            :.||..|:..|::.||||..||:|..|:...|||||:.||.:|:|||..||.:||..||..|.||
Zfish   195 ETINTRLISGVVQSYVELGLNEDDAFAKGPTLSVYKEYFETQFLADTERFYTRESTEFLQQNPVT 259

  Fly   250 EYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADR 314
            ||:|..|.||.||.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:
Zfish   260 EYMKKAEARLLEEQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADK 316

  Fly   315 NDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNA 379
            |:||.|||:||:..:..|.:||.:||.||.:||..||.| |...|.||||.||||||||||||||
Zfish   317 NEDLGRMYNLVSRITDGLGELKKLLETHIYNQGLAAIEK-CGESALNDPKMYVQTILDVHKKYNA 380

  Fly   380 LVLTAFNNDNGFVAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELED 443
            ||::|||||.|||||||||||:|||:|.|| :..|:||||||||:|||.||||||||||:.||||
Zfish   381 LVMSAFNNDAGFVAALDKACGRFINNNAVTKMVQSSSKSPELLARYCDSLLKKSSKNPEEAELED 445

  Fly   444 NLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQ 508
            .|||||||||||||||||||:|:||||||||:..||||||||.|||||||.||:|||.|||||||
Zfish   446 TLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQ 510

  Fly   509 DIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAAR 573
            |||||||||..||::|.... .:::||.|:||||||||||.|..|.||||||||.::|..|||:|
Zfish   511 DIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASR 574

  Fly   574 HSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQEN 638
            ||||||.|||.:.||||:.|..:|.   ||||||||||::|||:|.:..:|||||.|:||.:.:.
Zfish   575 HSGRKLTWLYHLSKGELVTNCFKNR---YTLQASTFQMAILLQYNTEDVYTVQQLTDSTQIKIDI 636

  Fly   639 LIQVLQILLKAKVLTSSD-----NENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVH 698
            |:||||||||:|:|...|     :|....|::.::|||.|||||.|:|||.|:|||.|.||||.|
Zfish   637 LVQVLQILLKSKLLVLEDENANVDEVEFKPDTLIKLFLGYKNKKLRVNINVPMKTEQKQEQETTH 701

  Fly   699 KHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERM 763
            |:|||||||||||||||||||||.|.|..|::|||||||:||||:|||||||||||||||||||:
Zfish   702 KNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLAEVLNQLSSRFKPRVPVIKKCIDILIEKEYLERV 766

  Fly   764 EGHKDTYSYLA 774
            :|.||||||||
Zfish   767 DGEKDTYSYLA 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	401/665 (60%)
		CULLIN	454..593	CDD:214545	99/138 (72%)
		Cullin_Nedd8	701..765	CDD:214883	54/63 (86%)
cul1a	NP_955953.2	Cullin	22..661	CDD:307166	399/654 (61%)
cul1a	NP_955953.2	Cullin_Nedd8	704..771	CDD:214883	55/66 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594794
Domainoid	1	1.000	753	1.000	Domainoid score	I89
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	928	1.000	Inparanoid score	I346
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	1	1.000	-	-		FOG0003709
OrthoInspector	1	1.000	-	-		otm25213
orthoMCL	1	0.900	-	-		OOG6_101330
Panther	1	1.100	-	-	LDO	PTHR11932
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R262
SonicParanoid	1	1.000	-	-		X1841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800