Protein Alignment Cul1 and Cul4b

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001100421.1
• Gene: Cul4b / 302502
• RGDID: 1564494
• Length: 971
• Species: Rattus norvegicus
• Alignment Length: 765
• Identity: 238/765 - (31%)
• Similarity: 388/765 - (50%)
• Gaps: 72/765 - (9%)

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCT-SVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |:.|.:|.|.: :..::..|: :......|..|.:.|: .:||                  .||.
  Rat   272 DETWQKLKEAV-EAIQNSTSI-KYNLEELYQAVENLCSYKISA------------------NLYK 316

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:.:|:..|.:.|| |.:..:.|:::.....::..|..:|:|.:|.:     .
  Rat   317 QLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQ-----N 376

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  |.:.......:|..||.||.|:.|:|||:|.::....:
  Rat   377 SMLPSIWDMGLELFRAHIISDQKVQTKTIDGILLLIERERNGEAIDRSLLRSLLNMLSD------ 435

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.:|:.:||.:|:.:|:..|..|....:....|.|||.||..|||||..|:
  Rat   436 --------LQIYQDSFEQRFLQETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRL------ 486

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||.:||...|.::.|:.|:.:|| .|......:||:.:|..||..:|.|.   |:....::
  Rat   487 --ITYLDQTTQKSLIASVEKQLLGEHLTAILQKGLNSLLDENRIQDLSLLYQLF---SRVRGGVQ 546

  Fly   337 SILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGK 401
            .:|::.|  :..:|.......:...| ||.||.:||...|.:.::.|.|..:..|:.|:.:|...
  Rat   547 VLLQHWI--EYIKAFGSTIVINPEKD-KTMVQELLDFKDKVDHIIDTCFLKNEKFINAMKEAFET 608

  Fly   402 FINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYS 466
            |||..       .:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:|.
  Rat   609 FINKR-------PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYK 666

  Fly   467 KMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTM 531
            |.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:...||||:..:|:..
  Rat   667 KDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPG 731

  Fly   532 EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNR 596
            .|:..:.:|:.|.||..:.....||.|:.:....|..||..:||||||.|  |...|..::....
  Rat   732 NIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQW--QSTLGHCVLKAEF 794

  Fly   597 NNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDNEN 659
            ..... .||.|.||..|||.||:...|::::::..|..:...|.:.||.|.  ||:||..:....
  Rat   795 KEGKK-ELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAKNPKGK 858

  Fly   660 SLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLN 724
            .:..........|:|:|..||.|||....|...||.:..:.:.:||:..|.|||||||||||.|:
  Rat   859 DIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLS 923

  Fly   725 HTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |..|:|||.|||  :|..|...:||.|:.||:::|:||.:.:.:.|:|:|
  Rat   924 HNLLVSEVYNQL--KFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	190/659 (29%)
		Cullin_Nedd8	704..765	CDD:463146	33/60 (55%)
Cul4b	NP_001100421.1	Cullin	275..872	CDD:459983	190/659 (29%)
		Cullin_Nedd8	903..963	CDD:463146	33/61 (54%)