DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Cul1 and Cul3

DIOPT Version :9

Sequence 1:NP_523655.1 Gene:Cul1 / 35742 FlyBaseID:FBgn0015509 Length:774 Species:Drosophila melanogaster
Sequence 2:NP_001100393.2 Gene:Cul3 / 301555 RGDID:1308190 Length:768 Species:Rattus norvegicus


Alignment Length:812 Identity:229/812 - (28%)
Similarity:396/812 - (48%) Gaps:118/812 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 QKLVNLDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHVYDYCTSVSAAPSGRSSGKT 68
            :|.||  .||..|...|.::.....|      |.|:.| |..:.|                    
  Rat    27 EKYVN--SIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKH-------------------- 69

  Fly    69 GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYTKQWKSYQFSSTVLDG 126
                  |:|||..|.:.:..:   |:.|.:    |:||       |....:.|..:|.:..::..
  Rat    70 ------GEKLYTGLREVVTEH---LINKVR----EDVLNSLNNNFLQTLNQAWNDHQTAMVMIRD 121

  Fly   127 ICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHL--FQVLNEPVTKAVLKSIEEERQGKLINR 189
            |..|::|.:|:      |..:..:|.|.|:.::..:  :..:.:.:.:.:|..|..||:|::::|
  Rat   122 ILMYMDRVYVQ------QNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR 180

  Fly   190 SLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKH 254
            ..:|:..:..:.|..         :..|||:::||..|:..::.|::.||..||:.|:.:.|:|.
  Rat   181 GAIRNACQMLMILGL---------EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKK 236

  Fly   255 VENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQN-----LLNADR 314
            ||.|:.||.:||        :..|.::|.:.:....|..||.||:|.. .|.:|     :|...:
  Rat   237 VEARINEEIERV--------MHCLDKSTEEPIVKVVERELISKHMKTI-VEMENSGLVHMLKNGK 292

  Fly   315 NDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNA 379
            .:||..||.|.:.....|..:...:.:::..||...:::   .....:|..|:|.:||:..:::.
  Rat   293 TEDLACMYKLFSRVPNGLKTMCECMSSYLREQGKALVSE---EGEGKNPVDYIQGLLDLKSRFDR 354

  Fly   380 LVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDN 444
            .:..:||||..|...:......|:|.|        |:|||.|:.:.|..|||..|...::|:|..
  Rat   355 FLQESFNNDRLFKQTIAGDFEYFLNLN--------SRSPEYLSLFIDDKLKKGVKGLTEQEVETI 411

  Fly   445 LNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQD 509
            |::.||:|:::::||||::||.:.||:||:.:.|.|||:|..||||||..||.::|.||:.||:|
  Rat   412 LDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRD 476

  Fly   510 IGVSKDLNSYFKQYLAEKNLTM-EIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFNEFYAA 572
            :.:|......|:|:|....::: .:|..:.||::|.||.|.:. ...:|.....:...|..||.|
  Rat   477 MSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLA 541

  Fly   573 RHSGRKLNWLYQMCKGELI-------------------MNVNRNNSSTYTLQASTFQMSVLLQFN 618
            :||||:|...:.|...:|.                   ..|..:|:..:.||.|||||::|:.||
  Rat   542 KHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN 606

  Fly   619 DQLSFTVQQLQDNTQTQQENLIQVLQILLKAK----VLTSSDNENSLTPESTVELFLDYKNKKRR 679
            ::..:|.:::|..|...:..|::.||.|...|    |||.......:.......:...:.:|..|
  Rat   607 NREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIESGHIFTVNDQFTSKLHR 671

  Fly   680 ININ--QPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
            :.|.  ...:.|...|::...:.:::|||..|:||||||||.||::.|..|::||..||..||.|
  Rat   672 VKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLP 736

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...||||.|:.|||:|||.|....:..|:|:|
  Rat   737 SPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cul1NP_523655.1 Cullin 21..669 CDD:279260 181/693 (26%)
CULLIN 454..593 CDD:214545 52/159 (33%)
Cullin_Nedd8 701..765 CDD:214883 35/63 (56%)
Cul3NP_001100393.2 Interaction with KLHL18. /evidence=ECO:0000250|UniProtKB:Q13618 2..41 6/15 (40%)
Cullin 34..665 CDD:395716 182/698 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 677..698 2/20 (10%)
Cullin_Nedd8 698..759 CDD:402267 35/60 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53685
OrthoDB 1 1.010 - - D1040292at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.930

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