Protein Alignment Cul1 and Cul1

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_036172.1
• Gene: Cul1 / 26965
• MGIID: 1349658
• Length: 776
• Species: Mus musculus
• Alignment Length: 789
• Identity: 493/789 - (62%)
• Similarity: 599/789 - (75%)
• Gaps: 32/789 - (4%)

  Fly     2 NRSGNSQTTQKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSV---------S 57
            |||.|.... |.:.||.||.:|..||.||:..: |:.:|:||..|||||:|||||         .
Mouse     4 NRSQNPHGL-KQIGLDQIWDDLRAGIQQVYTRQ-SMAKSRYMELYTHVYNYCTSVHQSNQARGAG 66

  Fly    58 AAPSGRSSGKT-GGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSS 121
            ..||....|:| ||||.||.:||.||::|||:||:.||...:.:..|.| |..||:||:.|:|||
Mouse    67 VPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESV-LKFYTQQWEDYRFSS 130

  Fly   122 TVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKL 186
            .||:|||.||||:||:|||:||:||||:||.||||.|:..||:.||:.||.||||.||:||.|:.
Mouse   131 KVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGET 195

  Fly   187 INRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEY 251
            ||..|:..|::.||||..||:|..|:...|:|||::||::|:|||..||.:||..||..|.||||
Mouse   196 INTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEY 260

  Fly   252 LKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRND 316
            :|..|.||.||.:||:        .||||:|.|.|...||:|||||||:||||||||||:||:|:
Mouse   261 MKKAEARLLEEQRRVQ--------VYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNE 317

  Fly   317 DLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALV 381
            ||.|||:||:.....|.:||.:||.||.:||..||.||... |.||||.||||:|||||||||||
Mouse   318 DLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA-ALNDPKMYVQTVLDVHKKYNALV 381

  Fly   382 LTAFNNDNGFVAALDKACGKFINSNVVT-IANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNL 445
            ::|||||.|||||||||||:|||:|.|| :|.|:||||||||:|||.||||||||||:.||||.|
Mouse   382 MSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTL 446

  Fly   446 NQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDI 510
            ||||||||||||||||||:|:||||||||:..||||||||.|||||||.||:|||.|||||||||
Mouse   447 NQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDI 511

  Fly   511 GVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHS 575
            |||||||..||::|.... .:::||.|:||||||||||.|..|.||||||||.::|..|||:|||
Mouse   512 GVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHS 575

  Fly   576 GRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLI 640
            ||||.||||:.||||:.|..:|.   ||||||||||::|||:|.:.::|||||.|:||.:.:.|.
Mouse   576 GRKLTWLYQLSKGELVTNCFKNR---YTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILA 637

  Fly   641 QVLQILLKAKVLTSSD-----NENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKH 700
            ||||||||:|:|...|     :|..|.|::.::|:|.|||||.|:|||.|:|||.|.||||.||:
Mouse   638 QVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702

  Fly   701 IEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEG 765
            |||||||||||||||||||||.|.|..|:.|||.|||:||||:|||||||||||||||||||::|
Mouse   703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDG 767

  Fly   766 HKDTYSYLA 774
            .||||||||
Mouse   768 EKDTYSYLA 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	403/668 (60%)
		Cullin_Nedd8	704..765	CDD:463146	50/60 (83%)
Cul1	NP_036172.1	Cullin	21..660	CDD:459983	399/654 (61%)
		Cullin_Nedd8	706..768	CDD:463146	50/61 (82%)