DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and pcu4

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_594195.1	Gene:	pcu4 / 2543116	PomBaseID:	SPAC3A11.08	Length:	734	Species:	Schizosaccharomyces pombe

Alignment Length:	768	Identity:	195/768 - (25%)
Similarity:	344/768 - (44%)	Gaps:	97/768 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LVEGIMQVFEHEKSLTRS-QYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDRLEQFL 86
            |..|..:::...::|||: |..|.:..:..:.:|              |.||    |.|..|.|:
pombe    46 LKTGYQELYSGVENLTRADQASRCFNILQHHMSS--------------GIQL----LKDSAESFI 92

  Fly    87 KSYLSELLTKFKAISGEEVLLSRYTKQ---WKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIY 148
            :            :.|.|...:..|..   |..:.....::..|..|:::.::....:      |
pombe    93 Q------------LEGTETDTNACTVVVGCWNKWLERVEIVQNIFYYMDKTFLSHHPD------Y 139

  Fly   149 -KIYRLALVAWKGHLFQVLN--EPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDTD 210
             .|..|:|..::..|..|.|  .|...::|:|.|.....|..:.:.::|.:
pombe   140 PTIEELSLSLFREKLMAVKNIQIPFLNSLLQSFENLHSSKSTDHAYLQDAM-------------- 190

  Fly   211 AEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGL 275
            ....:..:|...|...::...|.||:.||...:....:.|||::..:.||.|...|..|:.....
pombe   191 LMLHRTEMYSSVFVPMYLVMLSRFYDTESSQKIQELPLEEYLEYAMSSLEREDAYVEKFDIVRDK 255

  Fly   276 SYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLKSILE 340
            ..:.||.        :..||..||..........:........|.:|:|:..:.:.
pombe   256 KSIRETV--------QRCLITSHLDTLTKGISQFIEKRDAHSCKLLYALLQFNHET--------- 303

  Fly   341 NHILHQGTEAIA----KCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGK 401
            .:::...::.:.    |....::.:|  |.||.:|..||....:|..:|.:|.....|:.||...
pombe   304 EYLIQPWSDCLVDVGFKLVNDESKDD--TLVQELLSFHKFLQVVVDESFLHDETLSYAMRKAFET 366

  Fly   402 FINSNVVTIANSASKSP-ELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYY 465
            |||.    ...|..::| .|:|||.|.||:...:....|.|::..::::.:|:||..||:|:.||
pombe   367 FING----AKGSQREAPARLIAKYIDYLLRVGEQASGGKPLKEVFSEILDLFRYIASKDIFEAYY 427

  Fly   466 SKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLT 530
            ...:||||:.:.|||...|.|::..||:|||.::|..|:.||:|:.:||:..|.|:...|..||
pombe   428 KLDIAKRLLLNKSASAQNELMLLDMLKKTCGSQFTHSLEGMFRDVNISKEFTSSFRHSKAAHNL- 491

  Fly   531 MEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVN 595
             ..|..:.|||...||....::..||.::::.:..|.:||.::..|:|::|...:  |..|:..
pombe   492 -HRDLYVNVLSQAYWPSYPESHIRLPDDMQQDLDCFEKFYLSKQVGKKISWYASL--GHCIVKA- 552

  Fly   596 RNNSSTYTLQASTFQMSVLLQFNDQL---SFTVQQLQDNTQTQQENLIQVLQILLKAKV--LTSS 655
            |.......|..|.||..||||||:.|   ..:.|.|:.:|:....:|.:.||.|..|::  |...
pombe   553 RFPLGNKELSISLFQACVLLQFNNCLGGEGISYQDLKKSTELSDIDLTRTLQSLSCARIRPLVMV 617

  Fly   656 DNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMR 720
            ......:|::...:...:.:|..|:.|||....|.:.|...|.:.:..||:..:||:|||:||.:
pombe   618 PKSKKPSPDTMFYVNEKFTDKLYRVKINQIYLKEERQENSDVQEQVVRDRQFELQASIVRVMKQK 682

  Fly   721 KRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYL 773
            :::.|.:|:..|:|.:..|..|.|..:|..|:.|:|||||||.:  .|.|:|:
pombe   683 EKMKHDDLVQYVINNVKDRGIPLVSDVKTAIEKLLEKEYLERED--NDIYTYV 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	158/662 (24%)
		CULLIN	454..593	CDD:214545	49/138 (36%)
		Cullin_Nedd8	701..765	CDD:214883	26/63 (41%)
pcu4	NP_594195.1	COG5647	1..734	CDD:227934	195/768 (25%)
		CULLIN	416..554	CDD:214545	49/142 (35%)
		Cullin_Nedd8	663..730	CDD:214883	27/68 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820