DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul3

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_592949.1	Gene:	cul3 / 2542637	PomBaseID:	SPAC24H6.03	Length:	785	Species:	Schizosaccharomyces pombe

Alignment Length:	804	Identity:	229/804 - (28%)
Similarity:	371/804 - (46%)	Gaps:	93/804 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 WSELVEGIMQVFEHEKS------LTRSQYM--------RFYTHVYDYCTSVSAAPSGRSSGKTGG 70
            |..|...|..:|:...|      |.|:.|:        :.|.||.|...|.....:..:..|...
pombe    26 WEVLQRAIGDIFQKSTSQLSFEELYRNAYILVLHKYGEKLYNHVQDVIRSRLKEETVPAIYKNYD 90

  Fly    71 AQLVGKKLYD--RLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNR 133
            |.|:|..|.|  :.:.:..|:       .:::......||.....||.:..|..::..:..||::
pombe    91 ASLLGNALLDIRKNDSYSTSW-------SRSLEAAHRFLSSLVNSWKDHIVSMQMISSVLKYLDK 148

  Fly   134 NWVKR--ECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVI 196
            .:.|.  :....:.|||....:.|:    :.|:: .|...:.:|..:..||:|..|||.|:.|.:
pombe   149 VYSKSADKVPVNENGIYIFREVVLL----NSFEI-GEKCVETILILVYLERKGNTINRPLINDCL 208

  Fly   197 ECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEE 261
            :....|       .:|.:|.::|...|..||::.|..|||.||...:....|.||||..|.|.||
pombe   209 DMLNSL-------PSENKKETLYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEE 266

  Fly   262 ETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIF----HTEFQNLLNADRNDDLKRMY 322
            |.:|     |||   ||....|..|.|..|:.|:.|||...    .|.|.:::::...:.|:.:|
pombe   267 EKER-----SKN---YLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQLVY 323

  Fly   323 SLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPK--------------TYVQTILDV 373
            ...:.....:..||..|..::.|.| :.|.:  ||..|.:.|              .:||.:|.:
pombe   324 ESFSRVELGVKSLKKYLAKYVAHHG-KLINE--TTSQALEGKMAVGRLSSNATMATLWVQKVLAL 385

  Fly   374 HKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPED 438
            ..:.|.::.|..:.|...:.:|..|        .||..:..:::||.::.:.|..|||.::...:
pombe   386 WDRLNTIISTTMDADRSILNSLSDA--------FVTFVDGYTRAPEYISLFIDDNLKKDARKAIE 442

  Fly   439 KELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKL 503
            ..:|..|...:.:|::|.:||||:|||...|||||:|:.|.|.|||..|||:|||..|..:|.||
pombe   443 GSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKL 507

  Fly   504 QRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSN-----NFLLPSELERSV 563
            :.||.|:.:|::|...:|...|.::....:|..:.:|:|..||..||.     ||  |..|...:
pombe   508 EGMFNDMNLSQELLQEYKHNSALQSAKPALDLNVSILASTFWPIDLSPHKIKCNF--PKVLLAQI 570

  Fly   564 RQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFND---QLSFTV 625
            .||.:||.::|:||||.|...|...::.:|.   ....|.|..||....:||.|.|   ......
pombe   571 DQFTDFYLSKHTGRKLLWYPSMGSADVRVNF---KDRKYDLNVSTIASVILLLFQDLKENQCLIF 632

  Fly   626 QQLQDNTQTQQENLIQVLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKT 688
            :::.:.|..:..:|.:.||.|  .|.|:|........:..........::.:...||.|:...:|
pombe   633 EEILEKTNIEVGDLKRNLQSLACAKYKILLKDPKGREVNAGDKFYFNENFVSNLARIKISTVAQT 697

  Fly   689 ELKVEQE---TVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKC 750
            .::.:.|   |:.| ::|.||....|.|||:||.||...|..|::||..||:.||.|...:||:.
pombe   698 RVEDDSERKRTLEK-VDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKRR 761

  Fly   751 IDILIEKEYLERMEGHKDTYSYLA 774
            |:.|||:|||:|...:...|.|||
pombe   762 IEALIEREYLQRQADNGRIYEYLA 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	187/693 (27%)
		CULLIN	454..593	CDD:214545	58/143 (41%)
		Cullin_Nedd8	701..765	CDD:214883	30/63 (48%)
cul3	NP_592949.1	COG5647	1..785	CDD:227934	227/802 (28%)
		CULLIN	458..601	CDD:214545	58/144 (40%)
		Cullin_Nedd8	717..777	CDD:287520	28/59 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820