Protein Alignment Cul1 and cul3

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_592949.1
• Gene: cul3 / 2542637
• PomBaseID: SPAC24H6.03
• Length: 785
• Species: Schizosaccharomyces pombe
• Alignment Length: 804
• Identity: 229/804 - (28%)
• Similarity: 371/804 - (46%)
• Gaps: 93/804 - (11%)

  Fly    20 WSELVEGIMQVFEHEKS------LTRSQYM--------RFYTHVYDYCTSVSAAPSGRSSGKTGG 70
            |..|...|..:|:...|      |.|:.|:        :.|.||.|...|.....:..:..|...
pombe    26 WEVLQRAIGDIFQKSTSQLSFEELYRNAYILVLHKYGEKLYNHVQDVIRSRLKEETVPAIYKNYD 90

  Fly    71 AQLVGKKLYD--RLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNR 133
            |.|:|..|.|  :.:.:..|:       .:::......||.....||.:..|..::..:..||::
pombe    91 ASLLGNALLDIRKNDSYSTSW-------SRSLEAAHRFLSSLVNSWKDHIVSMQMISSVLKYLDK 148

  Fly   134 NWVKR--ECEEGQKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVI 196
            .:.|.  :....:.|||....:.|:    :.|:: .|...:.:|..:..||:|..|||.|:.|.:
pombe   149 VYSKSADKVPVNENGIYIFREVVLL----NSFEI-GEKCVETILILVYLERKGNTINRPLINDCL 208

  Fly   197 ECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEE 261
            :....|       .:|.:|.::|...|..||::.|..|||.||...:....|.||||..|.|.||
pombe   209 DMLNSL-------PSENKKETLYDVLFAPKFLSYTRNFYEIESSTVIGVFGVVEYLKKAEKRFEE 266

  Fly   262 ETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIF----HTEFQNLLNADRNDDLKRMY 322
            |.:|     |||   ||....|..|.|..|:.|:.|||...    .|.|.:::::...:.|:.:|
pombe   267 EKER-----SKN---YLFTKIASPLLSVVEDELLSKHLDDLLENQSTGFFSMIDSSNFEGLQLVY 323

  Fly   323 SLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPK--------------TYVQTILDV 373
            ...:.....:..||..|..::.|.| :.|.:  ||..|.:.|              .:||.:|.:
pombe   324 ESFSRVELGVKSLKKYLAKYVAHHG-KLINE--TTSQALEGKMAVGRLSSNATMATLWVQKVLAL 385

  Fly   374 HKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPED 438
            ..:.|.::.|..:.|...:.:|..|        .||..:..:::||.::.:.|..|||.::...:
pombe   386 WDRLNTIISTTMDADRSILNSLSDA--------FVTFVDGYTRAPEYISLFIDDNLKKDARKAIE 442

  Fly   439 KELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKL 503
            ..:|..|...:.:|::|.:||||:|||...|||||:|:.|.|.|||..|||:|||..|..:|.||
pombe   443 GSIEATLQNSVTLFRFISEKDVFEKYYKTHLAKRLLNNRSISSDAELGMISRLKQEAGNVFTQKL 507

  Fly   504 QRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSN-----NFLLPSELERSV 563
            :.||.|:.:|::|...:|...|.::....:|..:.:|:|..||..||.     ||  |..|...:
pombe   508 EGMFNDMNLSQELLQEYKHNSALQSAKPALDLNVSILASTFWPIDLSPHKIKCNF--PKVLLAQI 570

  Fly   564 RQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFND---QLSFTV 625
            .||.:||.::|:||||.|...|...::.:|.   ....|.|..||....:||.|.|   ......
pombe   571 DQFTDFYLSKHTGRKLLWYPSMGSADVRVNF---KDRKYDLNVSTIASVILLLFQDLKENQCLIF 632

  Fly   626 QQLQDNTQTQQENLIQVLQIL--LKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKT 688
            :::.:.|..:..:|.:.||.|  .|.|:|........:..........::.:...||.|:...:|
pombe   633 EEILEKTNIEVGDLKRNLQSLACAKYKILLKDPKGREVNAGDKFYFNENFVSNLARIKISTVAQT 697

  Fly   689 ELKVEQE---TVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKC 750
            .::.:.|   |:.| ::|.||....|.|||:||.||...|..|::||..||:.||.|...:||:.
pombe   698 RVEDDSERKRTLEK-VDESRKHQADACIVRVMKDRKVCEHNQLMAEVTRQLNPRFHPSPMMIKRR 761

  Fly   751 IDILIEKEYLERMEGHKDTYSYLA 774
            |:.|||:|||:|...:...|.|||
pombe   762 IEALIEREYLQRQADNGRIYEYLA 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	188/698 (27%)
		Cullin_Nedd8	704..765	CDD:463146	29/60 (48%)
cul3	NP_592949.1	COG5647	1..785	CDD:227934	227/802 (28%)