Protein Alignment Cul1 and cul-5

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_505616.2
• Gene: cul-5 / 179413
• WormBaseID: WBGene00000840
• Length: 765
• Species: Caenorhabditis elegans
• Alignment Length: 812
• Identity: 228/812 - (28%)
• Similarity: 394/812 - (48%)
• Gaps: 98/812 - (12%)

  Fly    14 VNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            :..|:.||: .:.|:....|:||:|.:.:...:.|||...:.|...|               .|:
 Worm     1 MQFDEEWSK-ADPIVHALLHQKSVTPAAWQDLFYHVYKITSWVDDGP---------------LKI 49

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEG 143
            .|.|.:.:..|:.|...:.:::..:..||..|.|:|..:...:.:|......::.:..:|...|.
 Worm    50 RDILTRCINDYVHEANKRIRSLQTDGSLLIGYIKEWNRFYQQANILPLPFKKIDESSRRRSVPET 114

  Fly   144 QKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEED 208
            .:  ..|..:.|..|...:|..::|.:....|:.::|||.|.:|:...|..:.|.:|.|  |:.
 Worm   115 PE--ESIRTVMLEKWNEIIFMNISEQLLVEALRLVKEERDGNIIDAQNVIGIRESFVAL--NDR- 174

  Fly   209 TDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVR------ 267
              |.:..|.||:|:||.:||..|:.:|:|.....|:...|.||:.:.:.:||||.||.:
 Worm   175 --AGEDPLLVYRQSFERQFIEQTTEYYKKICGNLLNELGVLEYMVYADKKLEEEQQRAKRYLEMN 237

  Fly   268 ----GFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVALS 328
                |.:.:..:..|.|:..|.:.:.|.:::..|.:                :.|:|:|.|:..:
 Worm   238 SPTSGKHMEKAVIALVESFEDTILAECSKLIASKDV----------------ERLQRLYRLIRRT 286

  Fly   329 SKNLTDLKSILENHILHQGTEAIAKCCTTDAAN---DPKTYVQTILDVHKKYNALVLTAFNNDNG 390
            ...:..:...::.||..:|...:    ..:|.|   ||:.|||.:|.:..|:::||...|.:|..
 Worm   287 RSGIDTVLKCIDTHIRTEGLNDM----RNNAENLSTDPERYVQQLLLMFDKFSSLVREGFCDDAR 347

  Fly   391 FVAALDKACGKFINSNVV----------TIANSASKSPELLAKYCDLLLKKS--SKNPEDKELED 443
            .:.|.|||....:|.:.:          ...:..||..||||.||||||:|:  ||....:|:::
 Worm   348 LLTARDKAFRAVVNDSSIFKTEMMNKKGRTLSVESKCAELLANYCDLLLRKTQLSKKLTSEEIDE 412

  Fly   444 NLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGY--EYTVKLQRM 506
            .||||::|.||:|:||||.:::...|::||:...||..:.|.||::||:: ||.  :...||.||
 Worm   413 KLNQVLLVLKYVENKDVFMRFHRAHLSRRLILEMSADQEKEEMMVTKLRE-CGMPSDAVNKLSRM 476

  Fly   507 FQDIGVSKDLNSYFKQYLAEKNLTMEI--DFGIEVLSSGSWPFQLSN--NFLLPSELERSVRQFN 567
            .|||.::||:||.||:.|...|....|  ...::||:.|:|....|.  .|.||.|||..|.:..
 Worm   477 LQDIELNKDMNSSFKKALTGTNNNKSIADSINMKVLNGGAWGRGGSERIRFSLPRELEDFVPEME 541

  Fly   568 EFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQL--SFTVQQLQD 630
            .||..:|:||||.|::....|.::...  .|...:.|:.:||||:||..|||:.  ..:::.|:.
 Worm   542 AFYKKQHNGRKLCWMHHWSSGTMVFGT--ANGGRFDLECTTFQMAVLFCFNDRAHDKISLETLRL 604

  Fly   631 NTQTQQENLIQVL-----------QILLKAKVLTSSDNENSLTPESTVELFLDY------KNKKR 678
            .|:.....|.:.|           |||| ..|.:::......|..:...:..|:      |:::|
 Worm   605 ATELPDAELNRTLLSLVAYPKMRYQILL-CDVPSTTVTARDFTDSTKFLINHDFNVVKNGKSQQR 668

  Fly   679 -RININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
             ::|:...|:..|:...|..|:.|...|:|.:|..||:|:|.||......|..|::..|...|.|
 Worm   669 GKVNLIGRLQLSLEANAEKEHESIVALRELRVQEGIVKILKTRKTYTLAQLTMELVEILKPLFIP 733

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...:||:.||.|||.:|:||.....:|:.|::
 Worm   734 NRKIIKEQIDWLIENKYMERRADDINTFVYIS 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	191/691 (28%)
		CULLIN	454..593	CDD:214545	55/144 (38%)
		Cullin_Nedd8	701..765	CDD:214883	25/63 (40%)
cul-5	NP_505616.2	Cullin	18..656	CDD:279260	189/683 (28%)
		CULLIN	423..562	CDD:214545	54/139 (39%)
		Cullin_Nedd8	692..759	CDD:214883	25/66 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820