Protein Alignment Cul1 and cul-3

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_503151.1
• Gene: cul-3 / 178547
• WormBaseID: WBGene00000838
• Length: 777
• Species: Caenorhabditis elegans
• Alignment Length: 834
• Identity: 220/834 - (26%)
• Similarity: 383/834 - (45%)
• Gaps: 122/834 - (14%)

  Fly     3 RSGNSQTTQK------LVNLDD-----IWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHV 49
            ||||. ..||      :..:|:     .|..|...|.::.....|      |.|:.| |..:.|
 Worm     4 RSGNG-GQQKMRIRPFMATIDEQYVTQTWELLKRAIQEIQRKNNSGLSFEELYRNAYTMVLHKH- 66

  Fly    50 YDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQW 114
                                     |::||:.|:..::.:::.:..:..........|....:.|
 Worm    67 -------------------------GERLYNGLKDVIQDHMASVRIRIIESMNSGSFLETVAESW 106

  Fly   115 KSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQV--LNEPVTKAVLKS 177
            ..:..:..::..|..|::|.:|.:     ...:..:|.|.|.|::..:.:.  :.:.:..|:|:.
 Worm   107 ADHTVAMVMIRDILMYMDRIYVAQ-----NNHVLPVYNLGLDAYRTEILRQNGIGDRIRDALLEL 166

  Fly   178 IEEERQGKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAF 242
            |:.:|:...||...:::..:..:.|..:..         :||:..||...:.:||.:|......:
 Worm   167 IKLDRKSNQINWHGIKNACDMLISLGIDSR---------TVYEDEFERPLLKETSDYYRDVCKNW 222

  Fly   243 LS-TNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEF 306
            || .|....||..||..:.:|..|..        .||.:.|...:....::|::.:|::.. ...
 Worm   223 LSGDNDACFYLAQVEIAMHDEASRAS--------RYLDKMTEAKILQVMDDVMVAEHIQTI-VYM 278

  Fly   307 QN-----LLNADRNDDLKRMYSLVALSSKNLT----DLKSILE--NHILHQGTEAIAKCCTTDAA 360
            ||     :|...:.:||.|::.:......::|    .||::|:  :..|::....|.|  ..|..
 Worm   279 QNGGVKFMLEHKKIEDLTRIFRIFKRIGDSVTVPGGGLKALLKAVSEYLNETGSNIVK--NEDLL 341

  Fly   361 NDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYC 425
            .:|..:|..:|.:...:::|:.|||.:|..|..........|:|||        .:|||.:|.|.
 Worm   342 KNPVNFVNELLQLKDYFSSLLTTAFADDRDFKNRFQHDFETFLNSN--------RQSPEFVALYM 398

  Fly   426 DLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISK 490
            |.:|:...|...|.|:::.|:.||::|:|:::||||:||:.:.|||||:...|.|||.|..:::|
 Worm   399 DDMLRSGLKCVSDAEMDNKLDNVMILFRYLQEKDVFEKYFKQYLAKRLLLDKSCSDDVEKALLAK 463

  Fly   491 LKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLL 555
            ||..||.::|.||:.||:|..:...|.:.|:.:...:...|.||..:.||::|.||....|..:|
 Worm   464 LKTECGCQFTQKLENMFRDKELWLTLATSFRDWREAQPTKMSIDISLRVLTAGVWPTVQCNPVVL 528

  Fly   556 PSELERSVRQFNEFYAARHSGRKL--NWL----------YQMCKGELIMNVNRNNSST------- 601
            |.||..:...|.::|..:|:||||  |.|          |...|..:....|....|:
 Worm   529 PQELSVAYEMFTQYYTEKHTGRKLTINTLLGNADVKATFYPPPKASMSNEENGPGPSSSGESMKE 593

  Fly   602 -----YTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK-----VLTSSD 656
                 ..||.:|.||.:|||||.....:.|||.|..:..:..|.:.||.|...|     ::..:.
 Worm   594 RKPEHKILQVNTHQMIILLQFNHHNRISCQQLMDELKIPERELKRNLQSLALGKASQRILVRKNK 658

  Fly   657 NENSLTPESTVELFLDYKNKKRRININQPL-KTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMR 720
            .::::.......:..::::|..|:.:.... |.|.:.|.....:.:|:||||.::||||||||.|
 Worm   659 GKDAIDMSDEFAVNDNFQSKLTRVKVQMVTGKVESEPEIRETRQKVEDDRKLEVEAAIVRIMKAR 723

  Fly   721 KRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |:|||.||::||..||..||.|...:||:.|:.|||:|||.|.|.....|.|:|
 Worm   724 KKLNHNNLVAEVTQQLRHRFMPSPIIIKQRIETLIEREYLARDEHDHRAYQYIA 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	167/702 (24%)
		Cullin_Nedd8	704..765	CDD:463146	36/60 (60%)
cul-3	NP_503151.1	Cullin	31..675	CDD:459983	167/702 (24%)
		Cullin_Nedd8	707..769	CDD:463146	37/61 (61%)