Protein Alignment Cul1 and cul-6

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_502412.1
• Gene: cul-6 / 178214
• WormBaseID: WBGene00000841
• Length: 729
• Species: Caenorhabditis elegans
• Alignment Length: 776
• Identity: 278/776 - (35%)
• Similarity: 431/776 - (55%)
• Gaps: 62/776 - (7%)

  Fly    14 VNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKL 78
            ::::.:|..|.:|:..::..| .:::..||..|..||:.||:.:.|.|..:|     .:...:.|
 Worm     1 MSIEAVWGTLQDGLNLLYRRE-HMSKKYYMMLYDAVYNICTTTTLANSNNNS-----PEFASEFL 59

  Fly    79 YDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEG 143
            |.:||.::::|:..:..:..|.||:| ||.:.|.:|.:::||:.:.:.|..|||||:|.::.|:.
 Worm    60 YKQLENYIRTYVIAIRDRISACSGDE-LLGKCTIEWDNFKFSTRICNCIFQYLNRNFVSKKVEDK 123

  Fly   144 QKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEED 208
            ...|.:||:|||..||...|.........|:|:.|..||.|..||.:.:..|:||..|
 Worm   124 NGEIVEIYKLALDIWKAEFFDNFKVKTIDAILELILLERCGSTINSTHISSVVECLTE------- 181

  Fly   209 TDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKN 273
                   |.:||.:||.:|:..|..||::|  ...|..||.||:..|||||.:|..|.|
 Worm   182 -------LDIYKVSFEPQFLDATKLFYKQE--VLNSKETVIEYMITVENRLFQEEYRSR------ 231

  Fly   274 GLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLKSI 338
              .||..:|.|:|..:||.:||...||..|:||:.||.|.:::.|.|||||....:..|.||:..
 Worm   232 --RYLGPSTNDLLIDSCESILISDRLKFLHSEFERLLEARKDEHLTRMYSLCRRVTHGLEDLRVY 294

  Fly   339 LENHILHQGTEAIAKCC-TTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKF 402
            ||..||.:|.|.:.:.. .:.....||.|:..:|:||:.|..|:..||:.:..|:.:||||...|
 Worm   295 LEKRILKEGHETLQRLAKDSGLKTTPKEYITKLLEVHEIYFNLINKAFDRNALFMQSLDKASKDF 359

  Fly   403 INSNVVTI----ANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQK 463
            |.:|.||:    .:.:::|.:.||:|||.||||:||..:    |..|::.:.|.|||.:|||||.
 Worm   360 IEANAVTMLAPEKHRSTRSADYLARYCDQLLKKNSKVQD----ETALDKALTVLKYISEKDVFQL 420

  Fly   464 YYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKN 528
            ||....::|::|::|||||||...|:.|..|.|.|||..|.:|.:|..:||||.:.||....||:
 Worm   421 YYQNWFSERIINNSSASDDAEEKFITNLTATEGLEYTRNLVKMVEDAKISKDLTTEFKDIKTEKS 485

  Fly   529 LTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMN 593
                |||.:.:.::|:||.......:||.||...:::|:.||.|.|:||:|||.|..|:||:
 Worm   486 ----IDFNVILQTTGAWPSLDQIKIILPRELSTILKEFDTFYNASHNGRRLNWAYSQCRGEV--- 543

  Fly   594 VNRNNSST----YTLQASTFQMSVLLQFNDQLSFTVQQLQ---DNTQTQQENLIQVLQILLKAKV 651
                ||..    |....:..|:..|..||:|.|||::|:.   :.|......::..|..::...:
 Worm   544 ----NSKAFEKKYVFIVTASQLCTLYLFNEQDSFTIEQISKAIEMTAKSTSAIVGSLNPVIDPVL 604

  Fly   652 LTSSDNE-NSLTPESTVELFLDYKNKKRRININQPLKTELKVEQET--VHKHIEEDRKLLIQAAI 713
            :....|| :...|::.|.|...|.|||.|:::...:| :...::||  |...:|.|||..|:|.|
 Worm   605 VVDKGNEKDGYPPDAVVSLNTKYANKKVRVDLTTAIK-KATADRETDAVQNTVESDRKYEIKACI 668

  Fly   714 VRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |||||.||.|.||.||:|:::||.:||.|.|.:||.||:||||:.|:.|.|...:.|.|||
 Worm   669 VRIMKTRKSLTHTLLINEIISQLKSRFTPNVQMIKICIEILIEQLYIRRSENEHNVYEYLA 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	228/665 (34%)
		Cullin_Nedd8	704..765	CDD:463146	35/60 (58%)
cul-6	NP_502412.1	Cullin	7..627	CDD:459983	228/665 (34%)
		Cullin_Nedd8	659..721	CDD:463146	36/61 (59%)