Protein Alignment Cul1 and cul-2

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_001023008.1
• Gene: cul-2 / 176806
• WormBaseID: WBGene00000837
• Length: 791
• Species: Caenorhabditis elegans
• Alignment Length: 809
• Identity: 250/809 - (30%)
• Similarity: 425/809 - (52%)
• Gaps: 87/809 - (10%)

  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGK 76
            |:|..|.:|.:|...|:.:. :.:.:|..|:...::.|||.|.|:...              :.:
 Worm    24 KVVEFDKVWVQLRPSIIDII-NLRPITNVQWHHKFSDVYDICVSIPTP--------------LSE 73

  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVK-REC 140
            :||:.::..::.::.:.......:. .::||..|.|.|:.:...:..:..:..|||:.:|| :.|
 Worm    74 RLYNEVKACIQEHVRQKRQDIVDVD-PDLLLQEYHKMWRVFHEGAIFIHRLFGYLNKQFVKQKRC 137

  Fly   141 EEGQK-----------GIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGK---LINRSL 191
            .:...           .:.:|..|||..||..|.:.:...:.|.:|.:|:.:|:|.   :.|.
 Worm   138 TDLDNFAQYAAFLQIPDVKEIGCLALEIWKEDLVKTILPQLVKLLLIAIDNDRKGNFPHIANE-- 200

  Fly   192 VRDVIECYVELSFNEEDTD------------AEQQKLSVYKQNFENKFIADTSAFYEKESDAFLS 244
            |..||..:|::    |:||            |.:...:.|:::||...:.||..:|...:...|:
 Worm   201 VSGVINSFVKM----EETDFDVVPAEGARYKARESTTAFYQESFEKPLLTDTEQYYSALAQKMLT 261

  Fly   245 TNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNL 309
            ..:.:||::.|...||:|..|.:        .||||::.:.:.:.|::|:|:.|....|....:|
 Worm   262 DLSCSEYMEQVIVLLEQEEMRAK--------KYLHESSVEKVITLCQKVMIKAHKDKLHAVCHDL 318

  Fly   310 LNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVH 374
            :..:.|.||:.||.|:......|:.:....|.::..:|.||:::   ....|.|:.:|:.:|.|:
 Worm   319 ITNEENKDLRNMYRLLKPIQAGLSVMVKEFEEYVKKKGLEAVSR---LTGENVPQQFVENVLRVY 380

  Fly   375 KKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDK 439
            .|:|.:....|.:|..|.:.||||....:||.  ....|..|:.|.||:|.|.|||||:|...:.
 Worm   381 NKFNDMKTAVFMDDGEFSSGLDKALQGVVNSK--EPGQSVPKASERLARYTDGLLKKSTKGLSET 443

  Fly   440 ELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQ 504
            :||..|:..:|:|:||||||:|||:||||||.||:..||.|.|||.:||:||||.||||:|.||.
 Worm   444 DLEAKLDSAIVIFRYIEDKDIFQKFYSKMLANRLIASTSISMDAEELMINKLKQACGYEFTSKLS 508

  Fly   505 RMFQDIGVSKDLNSYFKQYLAE-KNLTMEIDF---GIEVLSSGSWPF---QLSN----------- 551
            |||.|||:|::|::.|.:::|: |.:..::.|   ...:|.:||||.   |||.
 Worm   509 RMFTDIGLSQELSNNFDKHIADIKTVQPDVKFVPTQTMILQAGSWPLNAPQLSTNSNNQTAQDVA 573

  Fly   552 NFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQ 616
            ||.||..|:..:::|.:||..:|:||||.||:.|.:|::.:..   ....|..|...:||:.||.
 Worm   574 NFHLPRILQPVIQEFEKFYTGKHNGRKLTWLFNMSQGDVRLTY---LDKQYVAQMYVYQMAALLC 635

  Fly   617 FNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRIN 681
            |..:.:..|:.:.:......:.|::.::.:|...:||..|  .:||.:|.|.|.:...:|:.:..
 Worm   636 FERRDAILVKDIGEEIGVSGDYLLKTIRTILDVTLLTCDD--QNLTADSLVRLNMSMTSKRMKFR 698

  Fly   682 INQP-LKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVP 745
            :..| :...::.|||.|...:.:|||..::.|||||||.||.|.|..|::|:::|...||.|.||
 Worm   699 LQAPQVNKAVEKEQEAVANTVSQDRKYYMECAIVRIMKTRKVLKHNALVTEIMDQTKGRFSPDVP 763

  Fly   746 VIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            .|||.|:.||||.|::|.: ..|.|.|||
 Worm   764 FIKKSIEDLIEKMYIQRTD-QNDEYQYLA 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	204/697 (29%)
		Cullin_Nedd8	704..765	CDD:463146	32/60 (53%)
cul-2	NP_001023008.1	Cullin	32..662	CDD:459983	195/667 (29%)
		Cullin_Nedd8	722..784	CDD:463146	32/62 (52%)