DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul-4

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	NP_495525.2	Gene:	cul-4 / 174198	WormBaseID:	WBGene00000839	Length:	840	Species:	Caenorhabditis elegans

Alignment Length:	865	Identity:	216/865 - (24%)
Similarity:	379/865 - (43%)	Gaps:	187/865 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NRSGNSQTT--------QKLV--------NLDDI-----------------WSELVEGIMQVFEH 33
            :::|||..|        :|||        |.:|:                 |:.|.:.:..:.|.
Worm    71 SQTGNSSRTTATNERIKKKLVIKNFKANANQNDVAMGDTNIDSTDGSVGRDWAVLSDNVFAILED 135

  Fly    34 EKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDRL----EQFLKSYLSELL 94
            .|::|..:.:  ::.|...|....:                 |.|||||    .||.|| |.|.|
Worm   136 RKTVTTLEGL--FSKVRSVCDKNQS-----------------KVLYDRLVAIVVQFAKS-LKESL 180

  Fly    95 TKFKAI----SGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLAL 155
            ...:.:    ...|..|.::.:.|::|.....::..|..:|:                   |:||
Worm   181 NAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNIFLHLD-------------------RIAL 226

  Fly   156 VA--------WKGHLFQVLNEPVTKAVLKSIEEER--------QGKLINR----SLVRDVIECYV 200
            .|        |:..: |:..:.....:.|..:..:        ..|::.|    |.:|.:::...
Worm   227 GATDTEILPLWECFM-QIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSPLRSLVDMLQ 290

  Fly   201 ELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQR 265
            .:..:||               |....|:.....|..|....:......:|:::.|:::...:|.
Worm   291 TVHVSEE---------------FAKFLISQLREHYNNERIDKVPKMNCNDYMEYCEDQINRYSQL 340

  Fly   266 VR-GFNSKNGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALS 328
            |: .|:..:.|.       || ::|....||::.: :|...:|.:|:::|...|:.||::|....
Worm   341 VKVNFDEPSALK-------DV-QATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMFNLCRQC 397

  Fly   329 SKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFV- 392
            .....::::....::..:|.:.||.|...|       .|..:|...||.:.::..:|.:.|..|
Worm   398 VGGEDEVRTQFSKYLKKRGEKLIATCPDED-------LVSELLAFKKKVDFIMTGSFKSANDPVK 455

  Fly   393 --AALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKN-PEDKELEDNLNQVMVVFKY 454
              ..|..|...|:|..|       .:|.||::|:...||..|:|| .:|..|:..:::.:|:|:|
Worm   456 MRQCLSDAFESFVNKQV-------DRSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRY 513

  Fly   455 IEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSY 519
            :..||||:.||.:.|||||....|||.|||.|::.|||..||..:|.||:.||:|:..|::....
Worm   514 LRGKDVFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRL 578

  Fly   520 FKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQ 584
            |.|||...| ..:.:|...|::...||...:....:|.|:..::..:.:||..:|..|.:.|.:.
Worm   579 FNQYLEHMN-KEKANFTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHG 642

  Fly   585 M------------CKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQE 637
            :            ||.|||              |:.:|..:||.||...::||.::.::|:..:.
Worm   643 LASAVISASFRPGCKKELI--------------ATMYQTVILLLFNKCETWTVAEIVEHTKILEI 693

  Fly   638 NLIQVLQILL----KAKVLTSSDNENSLTPESTVELFLDYK--------NKKRRININQ-PLKTE 689
            .:::.:..||    |.|||...:...|...|.|||...:.|        .|:.|:.|.| .:||.
Worm   694 EVVKNVLALLGGRDKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQVNIKTA 758

  Fly   690 LKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDIL 754
            :: |.:.|.:.:..||:..|.||:|||||.||:|||..|::|:|.||  ||......|||.::.|
Worm   759 VE-ETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQL--RFPVSTADIKKRLESL 820

  Fly   755 IEKEYLERMEGHKDTYSYLA 774
            ||:||:.|......:|:|:|
Worm   821 IEREYISRDPEEASSYNYVA 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	162/697 (23%)
		CULLIN	454..593	CDD:214545	52/150 (35%)
		Cullin_Nedd8	701..765	CDD:214883	31/63 (49%)
cul-4	NP_495525.2	Cullin	123..740	CDD:279260	164/708 (23%)
		PKc_like	<253..336	CDD:304357	13/97 (13%)
		CULLIN	513..652	CDD:214545	47/139 (34%)
		Cullin_Nedd8	774..831	CDD:287520	29/58 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830