Protein Alignment Cul1 and cul-4

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_495525.2
• Gene: cul-4 / 174198
• WormBaseID: WBGene00000839
• Length: 840
• Species: Caenorhabditis elegans
• Alignment Length: 865
• Identity: 216/865 - (24%)
• Similarity: 379/865 - (43%)
• Gaps: 187/865 - (21%)

  Fly     2 NRSGNSQTT--------QKLV--------NLDDI-----------------WSELVEGIMQVFEH 33
            :::|||..|        :|||        |.:|:                 |:.|.:.:..:.|.
 Worm    71 SQTGNSSRTTATNERIKKKLVIKNFKANANQNDVAMGDTNIDSTDGSVGRDWAVLSDNVFAILED 135

  Fly    34 EKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGKKLYDRL----EQFLKSYLSELL 94
            .|::|..:.:  ::.|...|....:                 |.|||||    .||.|| |.|.|
 Worm   136 RKTVTTLEGL--FSKVRSVCDKNQS-----------------KVLYDRLVAIVVQFAKS-LKESL 180

  Fly    95 TKFKAI----SGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLAL 155
            ...:.:    ...|..|.::.:.|::|.....::..|..:|:                   |:||
 Worm   181 NAVEQVPLAEDNCEQYLEKFGQIWQAYPVKINLIRNIFLHLD-------------------RIAL 226

  Fly   156 VA--------WKGHLFQVLNEPVTKAVLKSIEEER--------QGKLINR----SLVRDVIECYV 200
            .|        |:..: |:..:.....:.|..:..:        ..|::.|    |.:|.:::...
 Worm   227 GATDTEILPLWECFM-QIFQKTFFPNIFKEFKATKLFNALYMAMQKIMQRYPVDSPLRSLVDMLQ 290

  Fly   201 ELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQR 265
            .:..:||               |....|:.....|..|....:......:|:::.|:::...:|.
 Worm   291 TVHVSEE---------------FAKFLISQLREHYNNERIDKVPKMNCNDYMEYCEDQINRYSQL 340

  Fly   266 VR-GFNSKNGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALS 328
            |: .|:..:.|.       || ::|....||::.: :|...:|.:|:::|...|:.||::|....
 Worm   341 VKVNFDEPSALK-------DV-QATVTNCLIQQAIPEILTHDFDDLIDSDNISDIGRMFNLCRQC 397

  Fly   329 SKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFV- 392
            .....::::....::..:|.:.||.|...|       .|..:|...||.:.::..:|.:.|..|
 Worm   398 VGGEDEVRTQFSKYLKKRGEKLIATCPDED-------LVSELLAFKKKVDFIMTGSFKSANDPVK 455

  Fly   393 --AALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKN-PEDKELEDNLNQVMVVFKY 454
              ..|..|...|:|..|       .:|.||::|:...||..|:|| .:|..|:..:::.:|:|:|
 Worm   456 MRQCLSDAFESFVNKQV-------DRSAELISKHFHTLLHSSNKNVSDDTTLDQMVDEAIVLFRY 513

  Fly   455 IEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSY 519
            :..||||:.||.:.|||||....|||.|||.|::.|||..||..:|.||:.||:|:..|::....
 Worm   514 LRGKDVFEAYYKRGLAKRLFLERSASVDAEKMVLCKLKTECGSAFTYKLEGMFKDMDASENYGRL 578

  Fly   520 FKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQ 584
            |.|||...| ..:.:|...|::...||...:....:|.|:..::..:.:||..:|..|.:.|.:.
 Worm   579 FNQYLEHMN-KEKANFTARVITPEYWPTYDTYEINIPKEMRDTLTDYQDFYRVQHGNRNVKWHHG 642

  Fly   585 M------------CKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQE 637
            :            ||.|||              |:.:|..:||.||...::||.::.::|:..:.
 Worm   643 LASAVISASFRPGCKKELI--------------ATMYQTVILLLFNKCETWTVAEIVEHTKILEI 693

  Fly   638 NLIQVLQILL----KAKVLTSSDNENSLTPESTVELFLDYK--------NKKRRININQ-PLKTE 689
            .:::.:..||    |.|||...:...|...|.|||...:.|        .|:.|:.|.| .:||.
 Worm   694 EVVKNVLALLGGRDKPKVLQRVEGGGSEKKEGTVENLKNEKFVVNSKFTEKRCRVRIAQVNIKTA 758

  Fly   690 LKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDIL 754
            :: |.:.|.:.:..||:..|.||:|||||.||:|||..|::|:|.||  ||......|||.::.|
 Worm   759 VE-ETKEVKEEVNSDRQYKIDAAVVRIMKARKQLNHQTLMTELLQQL--RFPVSTADIKKRLESL 820

  Fly   755 IEKEYLERMEGHKDTYSYLA 774
            ||:||:.|......:|:|:|
 Worm   821 IEREYISRDPEEASSYNYVA 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	164/702 (23%)
		Cullin_Nedd8	704..765	CDD:463146	31/60 (52%)
cul-4	NP_495525.2	Cullin	122..741	CDD:459983	165/710 (23%)
		Cullin_Nedd8	772..832	CDD:463146	31/61 (51%)