Protein Alignment Cul1 and CACUL1

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: NP_722517.3
• Gene: CACUL1 / 143384
• HGNCID: 23727
• Length: 369
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 60/266 - (22%)
• Similarity: 100/266 - (37%)
• Gaps: 75/266 - (28%)

  Fly   395 LDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIED-- 457
            ::.:..||: .||:||.:..|.....|....|.||.:|   |.|        .:.:.::.|..
Human   115 INTSTSKFL-MNVITIEDYKSTYWPKLDGAIDQLLTQS---PGD--------YIPISYEQIYSCV 167

  Fly   458 -KDVFQKYYSKM---LAKRLVNHTS-ASDDAEA----MMISKLKQTCG----------------- 496
             |.|.|::..:|   |.|::.||.. .|.:.:|    :.|.:.....|
Human   168 YKCVCQQHSEQMYSDLIKKITNHLERVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMN 232

  Fly   497 -YEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELE 560
             :....||.|..:|     ||...|.:::|||::...:..   :|.:.|.|||::     ||.:.
Human   233 KFYIETKLNRDLKD-----DLIKLFTEHVAEKHIYSLMPL---LLEAQSTPFQVT-----PSTMA 284

  Fly   561 RSVRQFNEFYAARHSGRKLNWLYQMCK---GELIMNV----NRNNSSTYTLQASTFQMSVLLQFN 618
            ..|:   ..|..|.     .|: ||..   .:.|.|:    ..:..|.|..|...||..::
Human   285 NIVK---GLYTLRP-----EWV-QMAPTLFSKFIPNILPPAVESELSEYAAQDQKFQRELI---- 336

  Fly   619 DQLSFT 624
             |..||
Human   337 -QNGFT 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	60/266 (23%)
		CULLIN	454..593	CDD:214545	37/170 (22%)
		Cullin_Nedd8	701..765	CDD:214883
CACUL1	NP_722517.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		Cullin	138..>256	CDD:279260	27/133 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..369		60/266 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5647
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900