Protein Alignment Cul1 and Cul3

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_061516687.1
• Gene: Cul3 / 1277848
• VectorBaseID: AGAMI1_007458
• Length: 785
• Species: Anopheles gambiae
• Alignment Length: 848
• Identity: 246/848 - (29%)
• Similarity: 409/848 - (48%)
• Gaps: 153/848 - (18%)

  Fly     5 GNSQTTQKLVN---------LDDIWSELVEGIMQVFEHEKS------LTRSQY-MRFYTHVYDYC 53
            |.||.....|.         ::.|||.|...|.::.:...|      |.|:.| |..:.|
Mosquito    13 GTSQIAMNFVKRIMTMDEKYVESIWSLLKNAIQEIQKKNNSGLSFEELYRNAYTMVLHKH----- 72

  Fly    54 TSVSAAPSGRSSGKTGGAQLVGKKLYDRLEQFLKSYLSELLTKFKAISGEEVL-------LSRYT 111
                                 |::||..|::.:..:|...:.       ||||       |....
Mosquito    73 ---------------------GERLYSGLKEVVTHHLESKVR-------EEVLRSFNCNFLQTLN 109

  Fly   112 KQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQKGIYKIYRLALVAWKGHLFQVLNEP-----VT 171
            :.|..:|.|..::..|..|::|.:|:      |..:..:|.|.|..::.   ||:..|     :.
Mosquito   110 QCWNDHQTSMVMIRDILMYMDRVYVQ------QNDVDNVYNLGLNIFRD---QVVRYPRIRDHMR 165

  Fly   172 KAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYE 236
            :.:|..:..||:|:.|:...:::..:..:.|..|:.         .||:::||..|:..::|||:
Mosquito   166 ETLLNMVMCERKGEAIDHIAIKNACQMLMVLGINQR---------WVYEEDFERPFLTQSAAFYK 221

  Fly   237 KESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKI 301
            .||..||:.|:.:.|::.||.|:.||.:|.:        .||.|:|...:....|:.||:||::.
Mosquito   222 LESQKFLAENSASVYIRRVEARITEEAERAK--------LYLDESTESRIVEVVEDELIKKHMRT 278

  Fly   302 FHTEFQN-----LLNADRNDDLKRMYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAAN 361
            . .|.:|     :|...:.:||..|:.|.:..|..|..:...:..::...|.:.:.:  ..:.:.
Mosquito   279 I-VEMENSGVVYMLQNTKTEDLACMHKLFSRVSGGLKTIADCVSQNLRSLGRDLVKE--EENGST 340

  Fly   362 DPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCD 426
            :|.|:||.:||:..:.:..:..:||||..|...:......|:|.|        |||||.|:.:.|
Mosquito   341 NPITFVQNLLDLKDRSDHFLYHSFNNDKTFKNMISSDFEHFLNLN--------SKSPEYLSLFID 397

  Fly   427 LLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKL 491
            ..|||..|...::|:|..|::.||:|:|:::||||::||...|||||:.:.|.|||:|..|||||
Mosquito   398 DKLKKGCKGMSEQEIETILDKTMVLFRYLQEKDVFERYYKAHLAKRLLLNKSVSDDSEKNMISKL 462

  Fly   492 KQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTME-IDFGIEVLSSGSWPFQ-LSNNFL 554
            |..||.::|.||:.||:|:.||..:...||.::...|..:| ::..:.:|::|.||.| ::.|..
Mosquito   463 KTECGCQFTSKLEGMFKDMSVSNTVMEEFKNHINNDNSALEGVELTVRILTTGFWPTQSVTPNCN 527

  Fly   555 LPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMN------------VNRNNSST------ 601
            :|:...::...|..||.|:||||:|....|:  |.:.||            ...|.|||
Mosquito   528 IPAAPRKAFETFKRFYLAKHSGRQLTLQPQL--GTVYMNAEFYGVKAEKEKTEGNCSSTAPSAGS 590

  Fly   602 ----------------YTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILLKAK 650
                            :.||.||:||.||:.||::...|.:.:|..|....::||:.||.|...|
Mosquito   591 SSAPTGGAASLDAPKRHVLQLSTYQMCVLMLFNNRERMTYEDIQQETDIPSKDLIRALQSLSMGK 655

  Fly   651 ------VLTSSDNENSLTPESTVELFLD--YKNKKRRININQ-PLKTELKVEQETVHKHIEEDRK 706
                  |.|...::..:   ||.|.:::  :.:|..::.|.. ..|.|.:.|::.....::||||
Mosquito   656 QQQRLLVRTPKTSKEIV---STDEFYVNDAFVSKFHKVKIQTVAAKGESEPERKETRSKVDEDRK 717

  Fly   707 LLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYS 771
            ..|:||||||||.|||:.|..|:|:|.:||.:||.|...:|||.|:.|||:|||.|....:..|.
Mosquito   718 HEIEAAIVRIMKARKRMPHNLLVSDVTSQLKSRFLPSPVIIKKRIEGLIEREYLARTPEDRKIYV 782

  Fly   772 YLA 774
            |||
Mosquito   783 YLA 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	196/720 (27%)
		Cullin_Nedd8	704..765	CDD:463146	35/60 (58%)
Cul3	XP_061516687.1	None