Protein Alignment Cul1 and Cul5

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_312548.6
• Gene: Cul5 / 1273558
• VectorBaseID: AGAMI1_004198
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 877
• Identity: 243/877 - (27%)
• Similarity: 396/877 - (45%)
• Gaps: 167/877 - (19%)

  Fly    11 QKLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVG 75
            ||....:|.|..:...::.:.:.|: :|.|::...:..|:..|......|
Mosquito     3 QKNSTFEDKWPSMRPVVLSLLKQER-VTPSEWQELFFAVHLVCLWDDKGP--------------- 51

  Fly    76 KKLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRE- 139
            .|:::.|:|.:.:|:.:...:..|...|:.||..|..:|:.:...|       |||...:.|.|
Mosquito    52 LKIHESLQQDIVAYIKQAQCRVLAQREEQALLKAYIVEWRKFFTQS-------NYLPLPFAKLES 109

  Fly   140 ------------------------------------------CEEG------------------- 143
                                                      |..|
Mosquito   110 CLQSKGSSSSSVSSSGGGASSSSASSSSATVTGAGSSHNSSACASGAGTSSGGGGGGGSSSSSSS 174

  Fly   144 --------QKGIYKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYV 200
                    :..|  :.:|.|.:|...:|..:...:.::.:|.:..||.|:..:..||..|.|.||
Mosquito   175 SSKKPNHAEDSI--VRKLMLDSWNQSIFMNIKHRLQESAMKLVHAERNGEAFDSQLVIGVRESYV 237

  Fly   201 ELSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQR 265
            .|..|.||      ||.:|::|||..::..|||||..::...|.||.|..::::.:.:|.||..|
Mosquito   238 NLCSNTED------KLEIYRENFEAAYLHATSAFYRLKASEQLQTNGVKSFMEYADAKLREEEAR 296

  Fly   266 VRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKRMYSLVALSSK 330
                    |..||...:...|...|..|||..||.....|...|:.|.....|:.|:.|:...:.
Mosquito   297 --------GERYLEPGSITALGQCCVTVLIGDHLPTLLAECAPLIEARETQRLQLMFRLLDRVAG 353

  Fly   331 NLTDLKSILENHILHQGTE---AIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFV 392
            .:..:...|||||:..|..   |.|...|.|:    :.||:.:|.:.::::.||..|||:|..|:
Mosquito   354 GVDPMLRDLENHIVQAGLADMVAAADIITQDS----EKYVERLLKLFRRFSDLVKEAFNDDPRFL 414

  Fly   393 AALDKACGKFIN-----------SNV-----VTIANSASKSPELLAKYCDLLLKKS--SKNPEDK 439
            .|.|||....:|           ||.     :.|:...||.|||||.|||:||:::  ||....:
Mosquito   415 TARDKAFKTVVNDITLFKLELPTSNTAMARGIKISTPESKCPELLANYCDMLLRRTPFSKRLTTE 479

  Fly   440 ELEDNLNQVMVVFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQT-CGYEYTVKL 503
            |:|..|..|::|.||:.:||||.:|:...|.:||:..:||..:.|..|:..|::. ...:|..||
Mosquito   480 EIESRLKDVLLVLKYVSNKDVFMRYHKAHLTRRLILDSSADSEKEEDMVEWLREVGMPADYVNKL 544

  Fly   504 QRMFQDIGVSKDLNSYFKQYLAEKNLTMEIDFGIEVLSSGSWPFQLSN-NFLLPSELERSVRQFN 567
            .||||||.||:|||:.|:     ...|......|::|::|:|...... :..||.|||..:.:..
Mosquito   545 ARMFQDIKVSEDLNTQFR-----SQTTRHDAINIKILNAGAWARGSERVSVSLPLELEDYIPEVE 604

  Fly   568 EFYAARHSGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQF----NDQLSFTVQQL 628
            |||..:||||||.|.:.|..|.:..   .||:..:.|..:||||:||..:    |:::|:  :.|
Mosquito   605 EFYKKKHSGRKLQWYHHMSNGTITF---ANNTGRFDLDVTTFQMAVLFAWNQRPNEKVSY--ENL 664

  Fly   629 QDNTQTQQENLIQVLQIL-----LKAKVLT---SSDNENSLTPESTV----ELFLDYKNKK--RR 679
            :..|:.....|.:.|..|     ||.::|.   :..|....| |:|:    :.|...||.|  ||
Mosquito   665 RLATELPDPELRRTLWSLVAFPKLKRQLLVYEPAISNPKDFT-ENTLFWVNQEFAIIKNGKPQRR 728

  Fly   680 ININQPLKTELKVE--QETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKP 742
            ..:|...:.:|..|  |:..::.|.:.|.|..|.||::||||||||::..|.:|:::.|...|.|
Mosquito   729 GKVNLVGRLQLSTERSQQEDNQSIVQLRILRTQEAIIKIMKMRKRLSNAALQAELVDILKNMFLP 793

  Fly   743 KVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ...:||:.::.|||.:|:.|.:...:|:.|:|
Mosquito   794 SKKMIKEQLEWLIEHKYMRRDDDDINTFIYMA 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	202/761 (27%)
		Cullin_Nedd8	704..765	CDD:463146	25/60 (42%)
Cul5	XP_312548.6	None