Protein Alignment Cul1 and Cul4

DIOPT Version :10

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_308149.4
• Gene: Cul4 / 1269506
• VectorBaseID: AGAMI1_009954
• Length: 756
• Species: Anopheles gambiae
• Alignment Length: 711
• Identity: 231/711 - (32%)
• Similarity: 362/711 - (50%)
• Gaps: 63/711 - (8%)

  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEE-VLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKREC 140
            :||..|...::.::...:..|.:.||:: |.|.:....|:|:.....::..|..||:|.:|.
Mosquito    96 QLYVNLTALVEQHVKANIVPFLSESGDKLVYLKKMNDYWQSHCQQMIMIRSIFLYLDRIYVL--- 157

  Fly   141 EEGQKGIYKIYRLALVAWKGHLFQVLNEPV----TKAVLKSIEEERQGKLINRSLVRDVIECYVE 201
              ....::.|:.:.|..::.|:  .:|..|    .:.:|..||:||.|..::|||::.::....:
Mosquito   158 --NNPTVHSIWEMGLELFRDHI--AMNNLVQARTVEGILILIEKERHGDTVDRSLLKSLLRMLSD 218

  Fly   202 LSFNEEDTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRV 266
                          |.:|:..||.||:..|...|:.|..|.:....|.:||:||:.||.||.:|:
Mosquito   219 --------------LQIYRDAFEQKFLMATKHLYQAEGQAKMEELDVPDYLQHVDKRLNEEEERL 269

  Fly   267 RGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLK-IFHTEFQNLLNADRNDDLKRMYSLVALSSK 330
            .        .||...|...|..|.|..||.:|:. |.......||..:|..||.|:|.|.:....
Mosquito   270 E--------HYLDGCTRHQLIVTVERQLINEHVTGILQKGLDQLLEENRLSDLTRLYKLFSRVKN 326

  Fly   331 NLTDLKSILENHILHQGTEAIAKCCTTDAANDP---KTYVQTILDVHKKYNALVLTAFNNDNGFV 392
            ..|:|.:....:|..:|...:.         ||   |:.||.:||...|.:.:|.|.|..:..|.
Mosquito   327 GTTELCAHFNAYIKKKGRTIVI---------DPEKDKSMVQDLLDYKDKMDNIVNTCFERNEKFG 382

  Fly   393 AALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIED 457
            .:|.:|...|||..       ::|..||:|||.|:.|:..:|...::|||..|:::||.|::|..
Mosquito   383 NSLREAFEYFINQR-------SNKPAELIAKYVDMKLRAGNKEATEEELEQILDKIMVQFRFIHG 440

  Fly   458 KDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQ 522
            ||||:.:|.|.|||||:...|||.|||..|:|||||.||..:|.||:.||:|:.:|:|:|..|||
Mosquito   441 KDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKQECGGGFTSKLEGMFKDMELSRDINFAFKQ 505

  Fly   523 YL--AEKNLTMEIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQM 585
            .:  :|......||..:.:|:.|.||........||.||.:....||:||.|:||||||.|  |.
Mosquito   506 SMQNSEHKELQNIDLTVNILTMGFWPTYPVMEVTLPQELLQYQSIFNKFYLAKHSGRKLQW--QP 568

  Fly   586 CKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--K 648
            ..|..::.. :.::....||.|.||..|||.||...:.|.::::.....:...|.:.||.|.  |
Mosquito   569 TLGHCVLKA-QFDAGPKDLQVSLFQALVLLLFNYNAAITFEEIRAAVNIENGELKRTLQSLACGK 632

  Fly   649 AKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAI 713
            |:|||.......:......:...::.||..||.|||....|...||:...:.:.:||:..|.|||
Mosquito   633 ARVLTKIPKGREVENTDKFQFNNEFTNKLFRIKINQIQMKETTEEQKATEERVYQDRQYQIDAAI 697

  Fly   714 VRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            ||||||||.|:|..||:|:..||:...||  ..:||.|:.||:::|:||.:.:::.|:|:|
Mosquito   698 VRIMKMRKTLSHNLLITELYKQLTFPVKP--ADLKKRIESLIDRDYMERDKDNQNQYNYVA 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	20..673	CDD:459983	187/608 (31%)
		Cullin_Nedd8	704..765	CDD:463146	31/60 (52%)
Cul4	XP_308149.4	Cullin	58..657	CDD:459983	187/608 (31%)
		Cullin_Nedd8	688..748	CDD:463146	31/61 (51%)