Protein Alignment Cul1 and cul2

DIOPT Version :9

• Sequence 1: NP_523655.1
• Gene: Cul1 / 35742
• FlyBaseID: FBgn0015509
• Length: 774
• Species: Drosophila melanogaster
• Sequence 2: XP_002935209.2
• Gene: cul2 / 100492608
• XenbaseID: XB-GENE-960931
• Length: 766
• Species: Xenopus tropicalis
• Alignment Length: 806
• Identity: 273/806 - (33%)
• Similarity: 443/806 - (54%)
• Gaps: 88/806 - (10%)

  Fly    12 KLVNLDDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCTSVSAAPSGRSSGKTGGAQLVGK 76
            ::|:.|:.|::|:..|..|...: .:.|:.:...::.:|..|.   |.|           :.:|:
 Frog     6 RVVDFDETWNKLLTTIKAVVMLD-YVERATWNDRFSDIYALCV---AYP-----------EPLGE 55

  Fly    77 KLYDRLEQFLKSYLSELLTKFKAISGEEVLLSRYTKQWKSYQFSSTVLDGICNYLNRNWVKR--- 138
            :||...:.||::::.:|.|  :.:...|.:|..|.:.|:.|...:..:|.:..|||..::|:
 Frog    56 RLYTETKIFLENHVQQLHT--RVLDSAEQVLVMYYRYWEEYSRGADYMDCLYRYLNTQYIKKNKL 118

  Fly   139 ---ECEEGQKGI------YKIYRLALVAWKGHLFQVLNEPVTKAVLKSIEEERQGKLINRSLVRD 194
               :.:.|..|:      .:|..|||..|:..:.:.|.:.:.:.:||.|:.:|.|:..|:.::..
 Frog   119 TEADLQYGYGGVDMNEPLMEIGELALDLWRKLMIEPLQDTLLRMLLKEIKRDRCGEDPNQKVIHG 183

  Fly   195 VIECYVELSFNEEDTDAEQQK----LSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHV 255
            ||..:|.:         ||.|    |..|::.||..|:|:|..:|::|:...|..:..::|::.:
 Frog   184 VINSFVHV---------EQYKKKFPLKFYQEIFELPFLAETGEYYKQEASNLLQESNCSQYMEKI 239

  Fly   256 ENRLEEETQRVRGFNSKNGLSYLHETTADVLKSTCEEVLIEKHLKIFHTEFQNLLNADRNDDLKR 320
            ..||::|..|.|        .|||.::.:.:...|::.::..||:..|.|..|::..:|..|:..
 Frog   240 LGRLKDEEIRCR--------KYLHPSSYNKVIHECQQRMVADHLQFLHAECHNIIRQERRSDMAN 296

  Fly   321 MYSLVALSSKNLTDLKSILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAF 385
            ||:|:...|..|..:...|:|||..:|..||:   .....|.|..:|:::|:||.|:..||.:..
 Frog   297 MYTLLRAVSNGLPHMIQELQNHIHDEGLRAIS---NLSQENMPTQFVESVLEVHSKFVQLVNSVL 358

  Fly   386 NNDNGFVAALDKACGKFINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMV 450
            |.|..|::|||||....:|...   ..|..|:|||||||||.:||||:|...:.|:||.|...:.
 Frog   359 NGDQHFMSALDKALTCVVNYRE---PKSVCKAPELLAKYCDNMLKKSAKGMTENEVEDKLTSFIT 420

  Fly   451 VFKYIEDKDVFQKYYSKMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKD 515
            |||||:|||||||:|::||||||::..|.|.|:|..||:||||.||||:|.||.||:.|:.||.|
 Frog   421 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEETMINKLKQACGYEFTSKLHRMYTDMSVSAD 485

  Fly   516 LNSYFKQYLAEKNLTMEIDFGIE----VLSSGSWPFQL--SNNFLLPSELERSVRQFNEFYAARH 574
            ||:.|..::  ||....||.||.    ||.:|:||...  |:.|.:|.|||:||:.|..||....
 Frog   486 LNNKFNNFI--KNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYNQHF 548

  Fly   575 SGRKLNWLYQMCKGELIMNVNRNNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENL 639
            |||||.||:.:|.||:.||.   ....|....:|:||:|||.||:....|.::|||:||..::.|
 Frog   549 SGRKLTWLHYLCTGEVKMNY---LCKPYVAMVTTYQMAVLLAFNNSEIVTYKELQDSTQMNEKEL 610

  Fly   640 IQVLQILLKAKVLTSSDNENSLTPESTVELFLDYKNKKRRININQPLKTE--------------- 689
            .:.::.||..|::....::..:..|||..|.:::.:|:.:..|..|::.:
 Frog   611 TKTIKSLLDVKMINHDSDKEDIDGESTFSLNMNFSSKRTKFKITTPMQKDTPQGAQPTCAEEAML 675

  Fly   690 ------LKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLNHTNLISEVLNQLSTRFKPKVPVIK 748
                  ..:|.|.....::||||:.:|||||||||.||.|.|..||.||::|...||.|.:.:||
 Frog   676 WRGERRFSLEVEQTRSAVDEDRKMYLQAAIVRIMKARKILRHNALIQEVISQSRARFNPSISMIK 740

  Fly   749 KCIDILIEKEYLERMEGHKDTYSYLA 774
            |||::||:|:|:||.:...|.|||:|
 Frog   741 KCIEVLIDKQYIERSQASADEYSYVA 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	223/669 (33%)
		CULLIN	454..593	CDD:214545	74/144 (51%)
		Cullin_Nedd8	701..765	CDD:214883	36/63 (57%)
cul2	XP_002935209.2	Cullin	14..644	CDD:395716	225/674 (33%)
		Cullin_Nedd8	696..756	CDD:402267	35/59 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010