DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cul1 and cul4b

DIOPT Version :9

Sequence 1:	NP_523655.1	Gene:	Cul1 / 35742	FlyBaseID:	FBgn0015509	Length:	774	Species:	Drosophila melanogaster
Sequence 2:	XP_017951653.1	Gene:	cul4b / 100151714	XenbaseID:	XB-GENE-963628	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	765	Identity:	237/765 - (30%)
Similarity:	389/765 - (50%)	Gaps:	72/765 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 DDIWSELVEGIMQVFEHEKSLTRSQYMRFYTHVYDYCT-SVSAAPSGRSSGKTGGAQLVGKKLYD 80
            |:.|.:| :|.::..::..|: :......|..|.:.|: .:||                  .||.
Frog   166 DETWQKL-KGAVEAIQNSTSI-KYNLEELYQAVENLCSYKISA------------------NLYK 210

  Fly    81 RLEQFLKSYLSELLTKFKAISGEEVL-LSRYTKQWKSYQFSSTVLDGICNYLNRNWVKRECEEGQ 144
            :|.|..:.::...:.:|:..:.:.|| |.:..|.|:.:.....::..|..:|:|.:|.:     .
Frog   211 QLRQICEDHIKAQIHQFREDALDSVLFLKKIDKCWQDHCRQMIMIRSIFLFLDRTYVLQ-----N 270

  Fly   145 KGIYKIYRLALVAWKGHLF--QVLNEPVTKAVLKSIEEERQGKLINRSLVRDVIECYVELSFNEE 207
            ..:..|:.:.|..::.|:.  |.:.......:|..||.||.|:.|:|||:|.::....:
Frog   271 SMLPSIWDMGLELFRNHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSD------ 329

  Fly   208 DTDAEQQKLSVYKQNFENKFIADTSAFYEKESDAFLSTNTVTEYLKHVENRLEEETQRVRGFNSK 272
                    |.:|:.:||.:|:.:|:..|..|....:....|.|||.||..|||||..||
Frog   330 --------LQIYQDSFEQRFLEETNRLYAAEGQRLMQEREVPEYLHHVNKRLEEEADRV------ 380

  Fly   273 NGLSYLHETTADVLKSTCEEVLIEKHL-KIFHTEFQNLLNADRNDDLKRMYSLVALSSKNLTDLK 336
              ::||.::|...|.:|.|:.|:.:|| ........:||:.:|..||..:|.|.   |:....::
Frog   381 --ITYLDQSTQKPLIATVEKQLLGEHLTATLQKGLNHLLDENRIQDLSLLYQLF---SRVRGGVQ 440

  Fly   337 SILENHILHQGTEAIAKCCTTDAANDPKTYVQTILDVHKKYNALVLTAFNNDNGFVAALDKACGK 401
            .:|::.|  :..:|.......:...| ||.||.:||...|.:.::...|..:..||.|:.:|...
Frog   441 VLLQHWI--EYIKAFGSTIVINPEKD-KTMVQELLDFKDKVDHVIDVCFLKNEKFVNAMKEAFET 502

  Fly   402 FINSNVVTIANSASKSPELLAKYCDLLLKKSSKNPEDKELEDNLNQVMVVFKYIEDKDVFQKYYS 466
            |||..       .:|..||:|||.|..|:..:|...|:|||..|:::|::|::|..||||:.:|.
Frog   503 FINKR-------PNKPAELIAKYVDSKLRTGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYK 560

  Fly   467 KMLAKRLVNHTSASDDAEAMMISKLKQTCGYEYTVKLQRMFQDIGVSKDLNSYFKQYLAEKNLTM 531
            |.|||||:...|||.|||..|:||||..||..:|.||:.||:|:.:|||:..:||||:..:|:..
Frog   561 KDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQYMQNQNVPG 625

  Fly   532 EIDFGIEVLSSGSWPFQLSNNFLLPSELERSVRQFNEFYAARHSGRKLNWLYQMCKGELIMNVNR 596
            .|:..:.:|:.|.||..:.....||.|:.:....|..||..:||||||.|  |...|:.::....
Frog   626 NIELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQW--QSTLGQCVLKAEF 688

  Fly   597 NNSSTYTLQASTFQMSVLLQFNDQLSFTVQQLQDNTQTQQENLIQVLQILL--KAKVLTSSDNEN 659
            |.... .||.|.||..|||.||:...|::::::..|..:...|.:.||.|.  :|:||..|....
Frog   689 NEGKK-ELQVSLFQTLVLLMFNEGDEFSLEEIRQATGIEDSELRRTLQSLACGRARVLVKSPKSK 752

  Fly   660 SLTPESTVELFLDYKNKKRRININQPLKTELKVEQETVHKHIEEDRKLLIQAAIVRIMKMRKRLN 724
            .:..........|::::..||.|||....|...||.:..:.:.:||:..|.|||||||||||.|:
Frog   753 DVDDGDKFTFNDDFRHQLFRIRINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLS 817

  Fly   725 HTNLISEVLNQLSTRFKPKVPVIKKCIDILIEKEYLERMEGHKDTYSYLA 774
            |..|:|||.|||  :|..|...:||.|:.||:::|:||.:.:.:.|:|:|
Frog   818 HNLLVSEVYNQL--KFPVKPADLKKRIESLIDRDYMERDKENPNQYNYVA 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cul1	NP_523655.1	Cullin	21..669	CDD:279260	190/654 (29%)
		CULLIN	454..593	CDD:214545	59/138 (43%)
		Cullin_Nedd8	701..765	CDD:214883	33/63 (52%)
cul4b	XP_017951653.1	Cullin	169..766	CDD:366357	191/659 (29%)
cul4b	XP_017951653.1	Cullin_Nedd8	794..859	CDD:214883	33/66 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53685
OrthoDB	1	1.010	-	-		D1040292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930