Protein Alignment Dgk and DGKI

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_047276976.1
• Gene: DGKI / 9162
• HGNCID: 2855
• Length: 1096
• Species: Homo sapiens
• Alignment Length: 1112
• Identity: 251/1112 - (22%)
• Similarity: 365/1112 - (32%)
• Gaps: 466/1112 - (41%)

  Fly   178 GGHLSHDPSKTGSVH-PMLTVTPSPLASGPSMFQASNP--ARRSVDSSPSHSATNHSQMSRNSSK 239
            |.||...|:..|... |......:....||....|..|  |..:...:||.||......:..||.
Human     7 GCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAGEEKGATGGSSS 71

  Fly   240 KSSNSVNCKIDAVSRILP-------AIGRHCPGSLESGSAQAEKRADIKLLARKLSHFDPLTLKV 297
            ..|.:.:|.:.|.....|       |.|   ..:|:..:|..:|..| :.|..||.:   ||.:
Human    72 SGSGAGSCCLGAEGGADPRGAGSAAAAG---AAALDEPAAAGQKEKD-EALEEKLRN---LTFR- 128

  Fly   298 PLKDVVCYLSLLEAGRPEDKLEFMFRLYDTDSNGVLDTAEMDAIVNQMMAVAEYLGWDVS----- 357
              |.|....::..||.                              |.:|.|..|...|:
Human   129 --KQVSYRKAISRAGL------------------------------QHLAPAHPLSLPVANGPAK 161

  Fly   358 ELRPILQEMMVEIDYDADGTVSLDEWQRGGMTTIPLLVLLGVDSTTLKEDGIHVWRLKHFSKPAY 422
            |.|..|                  :|....:                  :|.|:|...:.|.
Human   162 EPRATL------------------DWSENAV------------------NGEHLWLETNVSG--- 187

  Fly   423 CNLCL----NMLVGLGKKGL--CCVLCKYTVHERCVQHAPA---SCITTYVK--SKKPKCGGDLL 476
             :||.    |..|...|..|  .|.:||..||..|::....   .|..|:.:  |:.|: ...:.
Human   188 -DLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPR-ENFVR 250

  Fly   477 HHWVEGNCY-GRCSKCRKRIK---AYHG--ITGLTCRWCHMMLHNRCA----SSVKKECTLGEYS 531
            ||||..... |:|.:|.|..:   ::|.  |..::|.||....||:..    ..:::.|:||.::
Human   251 HHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHA 315

  Fly   532 ELIVPPTAICPAVLDR--------------------QRSVNQAHKATHFQITP-PDELSCPLLVF 575
            .:|||||.|......:                    :|.:.|.:|...|.|.| ...|..|||||
Human   316 AVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVF 380

  Fly   576 VNPKSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAM 640
            |||||||.||.::|:.|.:.||||||:|||:.|||:.|.|::.:|..|::.|||||||||:|..:
Human   381 VNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSIL 445

  Fly   641 DSIELASQPAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRASTVMLDRWSIEVTNTPHS 705
            |.::|:.||.:||:||||||||||.|.|||||..|.:.|::.:....:.|.||||::.|...|
Human   446 DELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNP-- 508

  Fly   706 DDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETE 770
             |:.|                            ||::
Human   509 -DLPP----------------------------EELE---------------------------- 516

  Fly   771 METMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETE 835
                                                                             
Human   517 ----------------------------------------------------------------- 516

  Fly   836 VDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVG 900
                                                                             
Human   517 ----------------------------------------------------------------- 516

  Fly   901 SNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTP 965
                                                      ||.
Human   517 ------------------------------------------DGV-------------------- 519

  Fly   966 NAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHK 1030
                                           |.:|.|:.|||||:|.||.:.::||..||.||.|
Human   520 -------------------------------CKLPLNVFNNYFSLGFDAHVTLEFHESREANPEK 553

  Fly  1031 FNSRMKNKLWYFEYATSETFAASCKNLHESIEIVCDGVALDLANGPHLQG-----VALLNIPYTH 1090
            ||||.:||::|...|.|:....|.::|.:.:::||||..|.    |.:|.     :..||||...
Human   554 FNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLT----PKIQELKFQCIVFLNIPRYC 614

  Fly  1091 GGSNLWGEHLSQKRIRKSAGPFGKSKKLRAGD-KEFSATSFNSVDLSVAIQDFGDRLIEVIGLEN 1154
            .|:..||                     ..|| .:|..            |...|..|||||. .
Human   615 AGTMPWG---------------------NPGDHHDFEP------------QRHDDGYIEVIGF-T 645

  Fly  1155 CLHMGQVRTGLRASGRRLAQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSE 1219
            ...:..::.|  ..|.||.||.||::.|.|:.|||:||||....|..|:::.:||..|:...:..
Human   646 MASLAALQVG--GHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRR 708

  Fly  1220 KGRGFFN 1226
            ......|
Human   709 TSMPLLN 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008	9/73 (12%)
		C1_DGKbeta_rpt1	403..468	CDD:410395	19/75 (25%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	16/60 (27%)
		DAGKc	573..694	CDD:214487	66/120 (55%)
		DAGKa	1003..1194	CDD:214486	65/196 (33%)
DGKI	XP_047276976.1	C1_DGKiota_rpt1	168..240	CDD:410400	19/93 (20%)
		C1_DGKiota_rpt2	249..323	CDD:410446	22/73 (30%)
		DAGKc	378..499	CDD:214487	66/120 (55%)
		DAGKa	526..683	CDD:214486	65/196 (33%)
		ANK repeat	956..987	CDD:293786
		ANKYR	<960..1095	CDD:440430
		ANK repeat	989..1022	CDD:293786
		ANK repeat	1024..1056	CDD:293786