Protein Alignment Dgk and DGKE

DIOPT Version :10

• Sequence 1: NP_724619.2
• Gene: Dgk / 35738
• FlyBaseID: FBgn0085390
• Length: 1230
• Species: Drosophila melanogaster
• Sequence 2: XP_047292915.1
• Gene: DGKE / 8526
• HGNCID: 2852
• Length: 709
• Species: Homo sapiens
• Alignment Length: 961
• Identity: 196/961 - (20%)
• Similarity: 283/961 - (29%)
• Gaps: 510/961 - (53%)

  Fly   410 HVWR-LKHFSKPAYCNLCLNMLVGLGKKGLCCVLCKYTVHERCVQHAPASCITTYVKSKKPKCGG 473
            |.|| ...||:|.||.:|...::    :|..|..|...|.|.|::.|          .|:.:|..
Human    78 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKA----------DKRFQCKE 128

  Fly   474 DLL-----------HHWVEGN---CYGRCSKCRKRIKAYHGITGLTCRWCHMMLHNRC-ASSVKK 523
            .:|           |||:.||   | ..|..|:::......:....|.||...:|:.| .:|:|.
Human   129 IMLKNDTKVLDAMPHHWIRGNVPLC-SYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMKNSLKN 192

  Fly   524 E-CTLGEYSELIVPPTAICPAVLDRQRSVNQAH--KATHFQITPPDELS---CPLLVFVNPKSGG 582
            | |..||:..||:||:.:        .|:||..  |.|.:::. ..:|.   .||::..|.:||.
Human   193 EKCDFGEFKNLIIPPSYL--------TSINQMRKDKKTDYEVL-ASKLGKQWTPLIILANSRSGT 248

  Fly   583 RQGDRILRKFQYMLNPRQVYDLSKGGPKEGLTLFKDLPRF--RVICCGGDGTVGWVLEAMDSIE- 644
            ..|:.:|.:|:.:|||.||:|::|..|.:.|.|...||.:  ||:.|||||||||||:|:|.::
Human   249 NMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDAVDDMKI 313

  Fly   645 ----------------------------------------------------------------- 644
                                                                             
Human   314 KVLVFKNYYRRTSKINILYIYIYIWVLLLFCCCCCFFLRYSLALSPRLECSGADTANCNLHFSGS 378

  Fly   645 --------------------------------------------------LASQ----------- 648
                                                              ||||
Human   379 SHPPTSAYKVAETIGVRYHAWLIFVFFVETGFHHVAWAAVKLLGSSDPPTLASQSAGITWGQEKY 443

  Fly   649 -PAIGVIPLGTGNDLARCLRWGGGYEGENIP--KLMDKFRRASTVMLDRWSIEVTNTPHSDDMRP 710
             |.:.|:||||||||:..|.||.||.|| ||  :::.....|..:.||||.::|||..:.:..:|
Human   444 IPQVAVLPLGTGNDLSNTLGWGTGYAGE-IPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKP 507

  Fly   711 KVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMA 775
            |
Human   508 K---------------------------------------------------------------- 508

  Fly   776 TMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHA 840
              ||
Human   509 --EF------------------------------------------------------------- 510

  Fly   841 AAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSD 905
                                                                             
Human   511 ----------------------------------------------------------------- 510

  Fly   906 NSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASS 970
                                                                             
Human   511 ----------------------------------------------------------------- 510

  Fly   971 VLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRM 1035
                                            .:|||||||.||.:.:.||..|||.|..|:||:
Human   511 --------------------------------TMNNYFSVGPDALMALNFHAHREKAPSLFSSRI 543

  Fly  1036 KNKLWYFEYATSETFAASCKNLHESIEIVCDG--VALDLANGPHLQGVALLNIPYTHGGSNLWGE 1098
            .||..|..|.|.:.....||:|::.:|:..||  |||     |.|:|:.:|||.|..||..|| |
Human   544 LNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVAL-----PSLEGIIVLNIGYWGGGCRLW-E 602

  Fly  1099 HLSQKRIRKSAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRT 1163
            .:                    ||:.:          .:|..|  |.|:||:|:....|..|::.
Human   603 GM--------------------GDETY----------PLARHD--DGLLEVVGVYGSFHCAQIQV 635

  Fly  1164 GLRASGRRLAQCSEV-IIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPML 1213
            .| |:..|:.|...| :|......|||:|||||.|.|||:.:|||....||
Human   636 KL-ANPFRIGQAHTVRLILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..117	CDD:464196
		EFh	317..386	CDD:238008
		C1_DGKbeta_rpt1	403..468	CDD:410395	16/58 (28%)
		C1_DGK_typeI_like_rpt2	477..528	CDD:410401	17/55 (31%)
		DAGKc	573..694	CDD:214487	58/252 (23%)
		DAGKa	1003..1194	CDD:214486	66/193 (34%)
DGKE	XP_047292915.1	C1_DGKepsilon_typeIII_rpt1	75..128	CDD:410351	18/63 (29%)
		C1_DGKepsilon_typeIII_rpt2	143..207	CDD:410403	21/64 (33%)
		DAGKc	239..491	CDD:214487	58/252 (23%)
		DAGKa	511..666	CDD:214486	66/193 (34%)