DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and DGK2

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_001318872.1	Gene:	DGK2 / 836497	AraportID:	AT5G63770	Length:	712	Species:	Arabidopsis thaliana

Alignment Length:	1026	Identity:	207/1026 - (20%)
Similarity:	299/1026 - (29%)	Gaps:	519/1026 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 MVEIDYDADGTVSLDEWQRGGMTTIPLLV---------LLGVDSTTLK--------------EDG 408
            |:|:.:      ||.:|........|.:.         ||.|..|.||              .:.
plant     1 MMEVGF------SLIQWLISSGADSPFIFGWLVTGSVGLLAVIYTFLKWQKKTSLNWVKAAAREK 59

  Fly   409 IHVWR-----LKHF---------SKPAYCNLCLNMLVG----LGKKGLC-----CVLCKYTVHER 450
            ..||:     |.|.         .:|:.|.:||..||.    ..|..|.     |.:|....|..
plant    60 KKVWKRLRVPLSHHQWTDDYGYGQQPSTCCVCLYSLVPGQNVSNKASLSIPVHRCAVCGVAAHFY 124

  Fly   451 CVQHAPASCITTYVKSKKPKC----GGD-LLHHWVE--------GNCYGRCSKCRKR-----IKA 497
            |...|...|          ||    |.| :.|||.|        .:....|..|.:.     |:|
plant   125 CSSSAAKDC----------KCVAQAGSDHVRHHWSERWVNMDDNADMTAFCFYCDEPCGIPFIEA 179

  Fly   498 ---YHGITGLTCRWCHMMLHNRCASSVKKE----CTLGEYSELIVPP------------------ 537
               :|      |.||..::|.:|...:.||    |.||....:|:.|
plant   180 SPMWH------CLWCQRLIHVKCHMIMSKESGDACDLGSLRRVILSPVHVKLNEANGVDGVLTTI 238

  Fly   538 ----------------------------------------TAICPAV---LDRQRSVN------- 552
                                                    |.:...|   |.|.||::
plant   239 KNELASIRGHVRRKRHRGKNGNGQSLNGKLLEDSVSDPVKTVVNGLVVKKLRRDRSIDCLKQVSD 303

  Fly   553 -----------QAHK-----ATHFQ------ITPPDELSCPLLVFVNPKSGGRQGDRILRKFQYM 595
                       ..||     |.:|.      ..|||  :.|||||:|.||||:.|..:.|:...:
plant   304 MPNAKGLQNGIGGHKRNKSAALNFMKKFSLVDLPPD--ARPLLVFINAKSGGQLGPFLHRRLNML 366

  Fly   596 LNPRQVYDL-SKGGPKEGLTLFKDLPRFRVICCGGDGTVGWVLEAMDSIELASQPAIGVIPLGTG 659
            |||.||::| |..||..||.|...:..|||:.|||||||.|||:|::.....|.|.:.::|||||
plant   367 LNPVQVFELGSCQGPDAGLDLCSKVKYFRVLVCGGDGTVAWVLDAIEKRNFESPPPVAILPLGTG 431

  Fly   660 NDLARCLRWGGG---YEGE-NIPKLMDKFRRASTVMLDRWSIEVTNTPHSDDMRPKVTLHSNMQK 720
            |||:|.|:||.|   .:|: ::...:.....|:..||||||:                      |
plant   432 NDLSRVLQWGRGISVVDGQGSLRTFLQDIDHAAVTMLDRWSV----------------------K 474

  Fly   721 VIELSQSVVVDKSLMERFEEIQRQSKQVATSMGTAASSTSIMMASKTETEMETMATMEFGSSTTT 785
            ::|.|         .|:|
plant   475 IVEES---------TEKF----------------------------------------------- 483

  Fly   786 TNRTTTTKSISMSTFETQCLQQTLRTAMSSSSSNTSSGSPCNGNQDAETEVDSHAAAAADVREKS 850

plant   484 ----------------------------------------------------------------- 483

  Fly   851 VPRRSGETEKQSLETLLLQHKQQMQQQQQQQQQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNN 915
             |.|.|             ||..|
plant   484 -PAREG-------------HKFMM----------------------------------------- 493

  Fly   916 ILKQQITLSLDLSDHEDEPKDDGGGAGDGTKSNGNSIPATPATPITPTTPNAASSVLQQQQQQHL 980

plant   494 ----------------------------------------------------------------- 493

  Fly   981 QFEQQQKPIKVQSDKDCTVPYNIINNYFSVGVDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYA 1045
                                     ||..:|.||.:..:||:.|::.|.||.|:..|||.|.:..
plant   494 -------------------------NYLGIGCDAKVAYEFHMMRQEKPEKFCSQFVNKLRYAKEG 533

  Fly  1046 TSETFAASCKNLHESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWG---EHLSQKRIRK 1107
            ..:....:|.:|...:.:..||..:::....  :|:.:|||....||.:||.   ||
plant   534 ARDIMDRACADLPWQVWLEVDGKDIEIPKDS--EGLIVLNIGSYMGGVDLWQNDYEH-------- 588

  Fly  1108 SAGPFGKSKKLRAGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRL 1172
                          |..||            ||...|:.:||:.:....|:|:::.|| :..|||
plant   589 --------------DDNFS------------IQCMHDKTLEVVCVRGAWHLGKLQVGL-SQARRL 626

  Fly  1173 AQCSEVIIKTKKTFPMQIDGEPWMQMPCTIKVTHKNQVPMLMAPRSEKGRG 1223
            ||...:.|.....||:||||||::|.|..:::||..||.||.. .|::.||
plant   627 AQGKVIRIHVSSPFPVQIDGEPFIQQPGCLEITHHGQVFMLRR-ASDEPRG 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008	5/18 (28%)
		EF-hand_7	318..382	CDD:290234	4/14 (29%)
		C1	410..459	CDD:237996	17/71 (24%)
		C1_1	477..528	CDD:278556	17/70 (24%)
		DAGKc	573..694	CDD:214487	55/125 (44%)
		DAGKa	1003..1194	CDD:214486	54/193 (28%)
DGK2	NP_001318872.1	C1	73..133	CDD:381770	13/59 (22%)
		C1_1	146..205	CDD:365894	16/64 (25%)
		DAGKc	344..470	CDD:214487	55/125 (44%)
		DAGK_acc	491..648	CDD:366191	55/324 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	120	1.000	Domainoid score	I1884
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000241
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102301
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.670