DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dgk and DGK4

DIOPT Version :9

Sequence 1:	NP_724619.2	Gene:	Dgk / 35738	FlyBaseID:	FBgn0085390	Length:	1230	Species:	Drosophila melanogaster
Sequence 2:	NP_200577.2	Gene:	DGK4 / 835876	AraportID:	AT5G57690	Length:	487	Species:	Arabidopsis thaliana

Alignment Length:	754	Identity:	146/754 - (19%)
Similarity:	218/754 - (28%)	Gaps:	375/754 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   519 SSVKKECTLGEYSELIVPPTAICPAVLDRQRSVNQAHKATHFQITPPDELSC-----PLLVFVNP 578
            :.:::...|.:|..:     ||...:|.:..|.:.:.     .:.||.|.:.     ||:|||||
plant    43 AELRQRVMLPQYLRI-----AIRDCILRKDDSFDASS-----SVAPPLENNALTPEVPLMVFVNP 97

  Fly   579 KSGGRQGDRILRKFQYMLNPRQVYDLSKGGPKE---------------GLTLFKDL-PRFRVICC 627
            |||||||..|..:.|.:::..|||||::..|.|               |....|:: .:.|::..
plant    98 KSGGRQGPLIKERLQNLISEEQVYDLTEVKPNEFIRYGLGCLEAFASRGDECAKEIREKMRIVVA 162

  Fly   628 GGDGTVGWVLEAMDSIELASQ---PAIGVIPLGTGNDLARCLRWGGGYEGENIPKLMDKFRRAST 689
            ||||||||||..:..:.|.::   |.:.::||||||||:|...|||.:.......:.....|||.
plant   163 GGDGTVGWVLGCLGELNLQNRLPVPPVSIMPLGTGNDLSRSFGWGGSFPFAWKSAIKRTLHRASV 227

  Fly   690 V---MLDRWSIEVTNTPHSDDMRPKVTLHSNMQKVIELSQSVVVDKSLMERFEEIQRQSKQVATS 751
            .   .||.|:|.:| .|..:.:.|..:|
plant   228 APISRLDSWNILIT-MPSGEIVDPPYSL------------------------------------- 254

  Fly   752 MGTAASSTSIMMASKTETEMETMATMEFGSSTTTTNRTTTTKSISMSTFETQCLQQTLRTAMSSS 816
                                  .||.|
plant   255 ----------------------KATQE-------------------------------------- 259

  Fly   817 SSNTSSGSPCNGNQDAETEVDSHAAAAADVREKSVPRRSGETEKQSLETLLLQHKQQMQQQQQQQ 881
                     |..:|:.|.|                    ||
plant   260 ---------CYIDQNLEIE--------------------GE------------------------ 271

  Fly   882 QQGVTSLAVEEAATATPVGSNQSDNSSQRNKQNNILKQQITLSLDLSDHEDEPKDDGGGAGDGTK 946

plant   272 ----------------------------------------------------------------- 271

  Fly   947 SNGNSIPATPATPITPTTPNAASSVLQQQQQQHLQFEQQQKPIKVQSDKDCTVPYNIINNYFSVG 1011
                         |.|:|..               :|                  .:..||||:|
plant   272 -------------IPPSTNG---------------YE------------------GVFYNYFSIG 290

  Fly  1012 VDAAICVKFHLEREKNPHKFNSRMKNKLWYFEYATSE-TFAASCKN------------LH----- 1058
            :||.:...||..|.:.|:..|..:.||:.|..|..|: .|...|.|            ||
plant   291 MDAQVAYGFHHLRNEKPYLANGPIANKIIYSGYGCSQGWFLTHCINDPGLRGLKNIMTLHIKKLD 355

  Fly  1059 ----ESIEIVCDGVALDLANGPHLQGVALLNIPYTHGGSNLWGEHLSQKRIRKSAGPFGKSKKLR 1119
                |.:.:           ...::.|..||:.....|.|.|| :|.|..:.|
plant   356 SSEWEKVPV-----------PKSVRAVVALNLHSYGSGRNPWG-NLKQDYLEK------------ 396

  Fly  1120 AGDKEFSATSFNSVDLSVAIQDFGDRLIEVIGLENCLHMGQVRTGLRASGRRLAQCSEVIIKTK- 1183
            .|..|..|               .|.|:|:.||:...|...|...| .|.:.:||.:.:.::.:
plant   397 RGFVEAQA---------------DDGLLEIFGLKQGWHASFVMVEL-ISAKHIAQAAAIRLEIRG 445

  Fly  1184 ---KTFPMQIDGEPWMQMPCT--------IK-VTHKNQV 1210
               |...||:|||||.| |.|        || |.|::.|
plant   446 GDWKDAFMQMDGEPWKQ-PMTRDYSTFVDIKRVPHQSLV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dgk	NP_724619.2	DAG_kinase_N	9..313	CDD:291199
		EFh	317..386	CDD:238008
		EF-hand_7	318..382	CDD:290234
		C1	410..459	CDD:237996
		C1_1	477..528	CDD:278556	0/8 (0%)
		DAGKc	573..694	CDD:214487	52/142 (37%)
		DAGKa	1003..1194	CDD:214486	52/216 (24%)
DGK4	NP_200577.2	DAGK_cat	90..230	CDD:395631	53/139 (38%)
DGK4	NP_200577.2	DAGK_acc	282..459	CDD:395484	52/216 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D633642at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780